Publications by authors named "Dinggai Chu"
Article Synopsis
- - Bone metastases from renal cell carcinoma (RCC) are linked to reduced quality of life and survival, with previous research identifying key dysregulated proteins in tumor cells that target bone.
- - In this study, six upregulated proteins in RCC tumor tissues correlated with poor survival, showed reverse relationships with VHL and PBRM1 genes, and were linked to Th17 cell enrichment versus CD8 T cell infiltration in the tumor microenvironment.
- - High levels of these proteins in pre-treatment tumors were associated with longer overall survival in patients treated with anti-PDL1 therapies, and a case study showed significant tumor reduction in a patient after treatment with atezolizumab based on protein expression.
