Publications by authors named "Dingcheng Sun"
The catalytic direct hydroarylation of alkynamides is a highly efficient approach for accessing functionalized trisubstituted arylalkenes with amide groups. Herein, we report a rhodium-catalyzed pyridylation of alkynamides with pyridylboronic acids, producing a variety of primary, secondary, and tertiary enamides with high yields (up to 94 %). This reaction demonstrates broad tolerance towards various alkyl and aryl functional groups, providing convenient access to a diverse array of alkenylpyridine derivatives.
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- Intracellular lipid buildup is often seen in fibrotic livers, but its precise impact on liver fibrosis is still unclear.
- Researchers used advanced imaging techniques to explore how different types of lipids are distributed in fibrotic livers, finding that unsaturated triglycerides mainly accumulate in the central vein area.
- The study highlighted that late-stage fibrosis displays significant disruptions in lipid homeostasis, leading to cell stress and death, but also suggests potential treatments by restoring lipid balance.