A nucleoside-modified rabies mRNA vaccine induces long-lasting and comprehensive immune responses in mice and non-human primates.

Rabies is a lethal zoonotic infectious disease. Vaccines against the rabies virus have significantly reduced the number of deaths from the disease. However, all the licensed rabies vaccines are inactivated vaccines, which have limited immunogenicity and complicated immunization procedures.

One-Step Electrodeposition of Silver Nanostructures on 2D/3D Metal-Organic Framework ZIF-67: Comparison and Application in Electrochemical Detection of Hydrogen Peroxide.

Metal-organic frameworks (MOFs) have been widely used as supporting materials to load or encapsulate metal nanoparticles for electrochemical sensing. Herein, the influences of morphology on the electrocatalytic activity of Co-containing zeolite imidazolate framework-67 (ZIF-67) as supporting materials were studied. Three types of morphologies of MOF ZIF-67 were facilely synthesized by changing the solvent because of the influence of the polar solvent on the nucleation and preferential crystal growth.