Publications by authors named "DingGuo Shen"
TAGNet: Learning Configurable Context Pathways for Semantic Segmentation.
IEEE Trans Pattern Anal Mach Intell
February 2023
State-of-the-art semantic segmentation methods capture the relationship between pixels to facilitate contextual information exchange. Advanced methods utilize fixed pathways for context exchange, lacking the flexibility to harness the most relevant context for each pixel. In this paper, we present Configurable Context Pathways (CCPs), a novel model for establishing pathways for augmenting contextual information.
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- Congenital myasthenic syndrome (CMS) is a group of rare genetic disorders causing muscle weakness due to issues with neuromuscular transmission.
- A 15-year-old girl diagnosed with limb-girdle CMS showed symptoms like limb weakness and ptosis, and muscle biopsies revealed abnormal changes alongside novel genetic mutations.
- The study emphasizes the importance of muscle biopsies and genetic testing in diagnosing rare CMS cases, guiding effective treatments that significantly improved the patient's condition.
Background: Several studies on clinical practice for Duchenne muscular dystrophy (DMD) have been conducted in Western countries. However, there have been only a few similar studies in Asia and Oceania. Here, we investigate the steroid therapy-related clinical practice for DMD among the local experts.
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- A rare case of GMPPB gene mutations was reported in a 29-year-old Chinese male with limb-girdle muscular dystrophy (LGMD), who had experienced progressive weakness for 19 years.
- The patient displayed symptoms such as a waddling gait, absent tendon reflexes, and myogenic damage, confirmed through electromyography and MRI showing fatty degeneration in thigh muscles.
- Genetic analysis revealed compound heterozygous mutations in the GMPPB gene, contributing new insights into the effects of these mutations within the Chinese population.
[Association of glucocorticoid receptor gene polymorphism with myasthenia gravis].
Zhonghua Yi Xue Za Zhi
November 2009
Objective: To investigate the association of two glucocorticoid receptor (GR) polymorphisms (BclI, ER22/23EK) with Myasthenia Gravis (MG).
Methods: The genotypes of GR in 61 MG patients (MGG) and 57 age and gender-matched healthy controls (HCG) were determined by polymerase chain reaction and nucleotide sequence determination.
Results: The frequencies of three genotypes (GG, CG, CC) in BclIwere 3.
[Effect of shexiang baoxin pill on the function of vascular endothelium in patients with diabetes mellitus type 2 complicated with angina pectoris].
Zhongguo Zhong Xi Yi Jie He Za Zhi
December 2004
Article Synopsis
- The study aimed to investigate the effects of Shexiang Baoxin pill (SBP) on vascular endothelial function in patients with type 2 diabetes and angina pectoris.
- After randomly assigning 111 patients to either the SBP group or a control group treated with isosorbide mononitrate, they were monitored for angina episodes and vascular changes over 6 months.
- Results showed no significant differences in angina episodes or medication use between the groups, but the SBP group exhibited a notable improvement in endothelium-dependent vascular relaxation after treatment, indicating enhanced endothelial function.
[Hemimasticatory muscle spasm: an electromyogram analysis].
Zhonghua Kou Qiang Yi Xue Za Zhi
March 2004
Article Synopsis
- The study aimed to evaluate the effectiveness of electromyogram (EMG) for diagnosing hemimasticatory spasm (HMS) in patients.
- Four patients diagnosed with HMS underwent both needle and surface electrode EMG testing.
- The results showed abnormal electrical activities in the trigeminal nerve during spasms, indicating that EMG is crucial for diagnosing HMS.
[Mitochondrial DNA mutations in patients with chronic progressive external ophthalmoplegia and Kearns-Sayre syndrome].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
August 2003
Objective: Kearns-Sayre syndrome (KSS) and chronic progressive external ophthalmoplegia (CPEO) belong to neurological diseases caused by a defect in the energy-producing system of mitochondria, and are known to be associated with a deletion in the mitochondrial genome. This study was aimed to understand with greater clearness the characteristics of mitochondrial DNA (mtDNA) mutations in 11 Chinese patients with CPEO (7 cases) or KSS (4 cases).
Methods: Densitometry of the bands on Southern blot, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing were performed to search large scale deletions and A3243G point mutation in patients' muscle mtDNA.
[Gene diagnosis of facioscapulohumeral muscular dystrophy].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
June 2003
Objective: To observe the characteristics of changes of p13E-11 labelled 4q35 EcoRI fragments and to make a gene diagnosis of facioscapulohumeral muscular dystrophy(FSHD).
Methods: Genomic DNA was extracted and was digested by EcoR I /Bln I. After pulsed field gel electrophoresis, it was hybridized with probe p13E-11 by Southern blot.
[Association between dystrophin and neuronal nitric oxide synthase in muscles of progressive muscular dystrophy].
Zhonghua Yi Xue Za Zhi
February 2002
Objective: To study the association between dystrophin and neuronal nitric oxide synthase in muscles of progressive muscular dystrophy patients and the role of deficiency of nNOS in pathogenesis of muscular dystrophy.
Methods: NADPH diaphorase enzyme histochemistry and anti-nNOS, anti-dystrophin, and anti-alpha, beta, gamma, delta-sarcoglycan antibody immunohistochemistry were used to analyze the muscle specimens from progressive muscular dystrophiy patients.
Results: Both nNOS and dystrophin were absent in the sarcolemma region of Duchenne muscular dystrophy (DMD) patients.