Publications by authors named "Ding-Ya Fang"
Article Synopsis
- Eight new compounds were discovered, including four zwitterionic alkylpyridinium salts (hippospondines A-D) and four 3-alkylpyridine alkaloids, along with one known alkaloid.
- The new compounds were analyzed using advanced techniques, and while compound 3 showed a slight boost in T lymphocyte proliferation, the overall findings highlight their unique chemical structures and potential for pharmacological applications.
Chemical and biological diversity of new natural products from marine sponges: a review (2009-2018).
Mar Life Sci Technol
August 2022
Unlabelled: Marine sponges are productive sources of bioactive secondary metabolites with over 200 new compounds isolated each year, contributing 23% of approved marine drugs so far. This review describes statistical research, structural diversity, and pharmacological activity of sponge derived new natural products from 2009 to 2018. Approximately 2762 new metabolites have been reported from 180 genera of sponges this decade, of which the main structural types are alkaloids and terpenoids, accounting for 50% of the total.
View Article and Find Full Text PDFTwo new 9,11-secosterols, hipposponols A () and B (), together with five known analogues, aplidiasterol B (), (3,5,6)-3,5,6-triol-cholest-7-ene (), (3,5,6,22)-3,5,6-triol-ergosta-7,22-diene (), and one pair of inseparable C-24 epimers of (3,5,6,22E)-3,5,6-triol-stigmasta-7,22-diene (/), were isolated from the marine sponge de Laubenfels. The structures of isolated compounds were extensively elucidated based on HRESIMS and NMR data. Compounds - showed cytotoxicity against PC9 cells with IC values ranging from 34.
View Article and Find Full Text PDFArticle Synopsis
- Three new polyacetylenes, named pellynols P (1), Q (2), and R (3), were discovered in the marine sponge Petrosia sp., alongside the already known pellynol H (4).
- Researchers determined the structures of these compounds using advanced techniques like NMR, HR-MS, and ESI-MS/MS.
- All four compounds showed strong cytotoxic effects against various cancer cell lines, with IC values ranging from 1.4 to 4.4 μM, indicating their potential as cancer treatments.
Background: Cardiogenic embolism caused by patent foramen ovale (PFO) is a common etiology of cryptogenic stroke (CS), particularly in young and middle-aged patients. Studies about right-to-left shunt (RLS) detection using contrast-enhanced transcranial Doppler (c-TCD) are numerous. According to the time phase and number of microbubbles detected on c-TCD, RLS can be classified and graded.
View Article and Find Full Text PDF[Treatment of rheumatoid arthritis arthralgia by xiaoyan zhitong paste: a clinical observation].
Zhongguo Zhong Xi Yi Jie He Za Zhi
October 2013
Objective: To formulate a comprehensive treatment program for rheumatoid arthritis arthralgia by clinical observing the efficacy of Xiaoyan Zhitong Paste (XZP).
Methods: Adopted was stratified, block randomized, double-blinded, placebo parallel controlled method. Subjects were assigned to the treatment group and the placebo group.
[Clinical study on active rheumatoid arthritis treated with simiao xiaobi decoction].
Zhongguo Zhong Xi Yi Jie He Za Zhi
March 2010
Objective: To observe the clinical efficacy and safety of Simiao Xiaobi Decoction (SXD) in treating active rheumatoid arthritis (RA) of humid pyretic toxic Bi-Zheng (HPTB) syndrome type.
Methods: One hundred and twenty RA patients were randomly assigned to 2 groups, 60 in the treatment group receiving SXD, and 60 in the control group receiving methotrexate, all were treated for 12 weeks. Clinical efficacy in patients was evaluated, referring to the criteria recommended by European League Against Rheumatoism (EULAR), in terms of effective rate, main symptoms, signs, scoring on symptom/sign by Chinese medicine scale and DAS28, physical and chemical indices, long-term outcome of patients and the average therapeutic effect initiating time.