Poly(ethylene oxide)- and Polyzwitterion-Based Thermoplastic Elastomers for Solid Electrolytes.

In this article, ABA triblock copolymer (tri-BCP) thermoplastic elastomers with poly(ethylene oxide) (PEO) middle block and polyzwitterionic poly(4-vinylpyridine) propane-1-sulfonate (PVPS) outer blocks were synthesized. The PVPSPEOPVPS tri-BCPs were doped with lithium bis-(trifluoromethane-sulfonyl) imide (LiTFSI) and used as solid polyelectrolytes (SPEs). The thermal properties and microphase separation behavior of the tri-BCP/LiTFSI hybrids were studied.

Microphase Separation with Sub-3 nm Microdomains in Comb-Like Poly(-alkyl acrylate) Homopolymers Facilitated by Charged Junction Groups between the Main Chains and Side Chains.

The phase structure with a small domain size in polymers is expected to provide a template for lithography to fabricate electronic devices, while the uniformity and thermal stability of the phase structure are vital in lithography. In this work, we report an accurately microphase-separated system of comb-like poly(ionic liquid) (PIL)-based homopolymers containing imidazolium cation junctions between the main chain parts and the long alkyl side chains, poly(1-((2-acryloyloxy)ethyl)-3-alkylimidazolium bromide) (P(AOEAI-Br)). The ordered hexagonally packed cylinder (HEX) and lamellar (LAM) structures with small domain sizes (sub-3 nm) were successfully achieved.

Electrostatic crosslinking-enabled highly asymmetric lamellar nanostructures of polyzwitterionic block copolymers for lithography.

For the bulk self-assembly of traditional diblock copolymers (di-BCPs), lamellar structures only occur when two constituents have similar volume fractions () and two alternating layers tend to have similar thicknesses. Highly asymmetric lamellar (A-LAM) structures, in which the thickness of one layer is several times higher than the other, are hardly formed in di-BCPs, while they have potential applications in nanolithography. In this work, A-LAM structures with different dimensions were constructed using a type of simple linear di-BCP, polystyrene--poly(4-vinylpyridine)propane-1-sulfonate (PS--PVPS) with the polyzwitterionic block PVPS in minority.

PEO-Based Block Copolymer Electrolytes Containing Double Conductive Phases with Improved Mechanical and Electrochemical Properties.

In this work, the advanced all solid-state block copolymer electrolytes (SBCPEs) for lithium-ion batteries with double conductive phases, poly(ethylene oxide)--poly(trimethyl--((2-(dimethylamino)ethyl methacrylate)-7-propyl)-ammonium bis(trifluoromethanesulfonyl) imide) (PEO--PDM-dTFSI)/LiTFSI, were fabricated, in which the charged PDM-dTFSI block contained double quaternary ammonium cations and the PEO block was doped with LiTFSI. The disordered (DIS) and ordered lamellae (LAM) phase structures were achieved by adjusting the composition of the block copolymer and the doping ratio . In addition, the presence of the hard PDM-dTFSI block and the formation of the LAM phase structure resulted in a good mechanical strength of the solid PEO--PDM-dTFSI/LiTFSI electrolyte, and it could maintain a high level of 10 Pa at 100 °C, which was around 10,000 times stronger than that of the PEO/LiTFSI electrolyte.

Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia.

Bone marrow (BM) niche responds to chemotherapy-induced cytokines secreted from acute lymphoblastic leukemia (ALL) cells and protects the residual cells from chemotherapeutics in vivo. However, the underlying molecular mechanisms for the induction of cytokines by chemotherapy remain unknown. Here, we found that chemotherapeutic drugs (e.

Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia.

B cell acute lymphoblastic leukemia (B-ALL) is the most common hematological malignancy diagnosed in children, and blockade of the abnormally activated PI3Kδ displayed promising outcomes in B cell acute or chronic leukemias, but the mechanisms are not well understood. Here we report a novel PI3Kδ selective inhibitor X-370, which displays distinct binding mode with p110δ and blocks constitutively active or stimulus-induced PI3Kδ signaling. X-370 significantly inhibited survival of human B cell leukemia cells in vitro, with associated induction of G1 phase arrest and apoptosis.

[Expression of zinc finger protein X-linked in childhood B lineage acute lymphoblastic leukemia].

Objective: To study the expression of zinc finger protein X-linked (ZFX) in bone marrow mononuclear cells (BMMCs) of children with B lineage acute lymphoblastic leukemia (B-ALL) and its relationship with prognosis.

Methods: The expression of ZFX in human leukemia cell lines (REH, HL-60, NB(4) and K562) was measured by Western blot. ZFX gene was cloned by PCR from one patient and DNA sequencing technology was used to confirm it.

[Hyperspectral Bambusoideae discrimination based on Mann-Whitney non-parametric test and SVM].

In the present study, based on the leaf-level hyperspectral data of MaoZhu, LeiZhu and XiaoShunZhu, We come up with two solutions to discrimination through the theory of non-parametric test and pattern recognition; the first one is that optimal discriminating band between bambusoideae species is extracted by Mann-Whitney non-parametric test, the other is that bambusoideae species is discriminated by the support vector machine. The research results showed that (1) the optimal discriminating band between MaoZhu and LeiZhu is around 503-655, 689-732, 757-1 000, 1 038-1 084, 1 238-1 311, 1 404-1 591, 1682-1 800, 1 856-1 904, and 1 923-2 500 nm; the optimal discriminating band between MaoZhu and XiaoShunZhu is around 350-386, 731-1 430, 1 584-1 687, and 1 796-1 873 nm; the optimal discriminating band between LeiZhu and XiaoShunZhu is around 355-356, 498-662, 689-745, and 1 344-2 500 nm; and it can eliminate 30.0%, 57.

[Hyperspectral feature band selection based on mean confidence interval and tree species discrimination].

In the present study, based on the leaf-level hyperspectral data of BaiMu, LeiZhu and WuHuanZi, the authors come up with two solutions through the theory of statistics; the first one is that optimal discriminating band between tree species is extracted by mean interval confidence, the other one is that tree species is discriminated by the Manhattan distance and the Min Max interval similarity. The research results showed that (1) the optimal discriminating bands between BaiMu and LeiZhu are around 350-446, 497-527, 553-1 330, 1 355-2 400 and 2 436-2 500 nm; the optimal discriminating bands between BaiMu and WuHuanZi are around 434-555, 580-1 903, 1 914-2 089, 2 172-2 457 and 2 475-2 500 nm; the optimal discriminating bands between LeiZhu and WuHuanZi are around 434-555, 580-1 903, 1 914-2 089, 2 172-2 457 and 2 475-2 500 nm; and this result is helpful for us to find maximum difference to identifying tree species respectively. (2) In these optimal discriminating bands, we find that the Manhattan distance between the same species is far less than the different species; but the Min-Max interval similarity between the same species is far more than the different species, so this result could help us to discriminate and identify different types of tree species effectively.

[Raman spectroscopy fluorescence background correction and its application in clustering analysis of medicines].

During Raman spectroscopy analysis, the organic molecules and contaminations will obscure or swamp Raman signals. The present study starts from Raman spectra of prednisone acetate tablets and glibenclamide tables, which are acquired from the BWTek i-Raman spectrometer. The background is corrected by R package baselineWavelet.

[Tree species discrimination based on leaf-level hyperspectral characteristic analysis].

The emergence of hyperspectral remote sensing technology will provide chance for solving problems of identifying forest tree species precisely. For discrimination of tree species with hyperspectral remote sensing technology, extraction and selection of the spectral characteristics is a very important process. Compared with multispectral data, hyperspectral data have the characteristics of more bands, larger amount of data and larger redundancy degree.