Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis.

Background: Liver ischemia/reperfusion (I/R) injury is usually caused by hepatic inflow occlusion during liver surgery, and is frequently observed during war wounds and trauma. Hepatocyte ferroptosis plays a critical role in liver I/R injury, however, it remains unclear whether this process is controlled or regulated by members of the DEAD/DExH-box helicase (DDX/DHX) family.

Methods: The expression of DDX/DHX family members during liver I/R injury was screened using transcriptome analysis.