Publications by authors named "Ding-Cheng Chan"

Article Synopsis
  • * In elderly individuals, hypertension can lead to serious health complications, including organ damage and additional health problems, which can complicate treatment due to their diminished physical and mental capacities.
  • * When addressing hypertension in older adults, thorough assessments are essential to weigh the benefits and risks of medications, and the review highlights the impact of hypertension on organ damage and frailty in this population.
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Article Synopsis
  • * It's important to carefully choose the right medicines and blood pressure goals to help these patients without causing more problems.
  • * Families and caregivers should help in making decisions about treatment to make sure it fits what the patient needs and keeps them safe.
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Aims: Advanced glycation end-products (AGEs) are implicated in the age-related decline of renal function, exacerbated by conditions, such as hyperglycemia and oxidative stress. The accumulation of AGEs in the kidneys contributes to the progressive decline in renal function observed with aging. However, the precise role and mechanisms of AGEs in the age-related decline of renal function remain unclear.

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Diabetic muscular atrophy is becoming a fast-growing problem worldwide, including sarcopenia, which is associated with substantial mortality and morbidity risk. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been marketed and suggested to exert protective effects on not only glycemic control but also diabetic complications in diabetic patients. In this study, we investigated the therapeutic use of GLP-1RAs exendin-4, compared to antidiabetic drug metformin, for the intervention of muscular dysfunction during diabetic conditions using a streptozotocin (STZ)-induced diabetic mouse model.

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The COVID-19 pandemic remains challenging due to the rapid evolution of the severe acute respiratory syndrome coronavirus 2. This article discusses recent findings on high-risk groups for COVID-19 mortality and morbidity, along with consensus statements from the 2023 Taiwan Association of Gerontology and Geriatrics (TAGG) meeting. It examines evidence on viral mutation mechanisms, emerging variants, and their implications for vaccination strategies.

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Article Synopsis
  • - The study aims to create a consensus in the Asia-Pacific region on long-term management and sequential therapy for osteoporosis, focusing on effective fracture prevention through individualized treatment strategies.
  • - A panel of experts analyzed current literature and expert opinions, resulting in 12 key recommendations, such as using anabolic agents for high fracture risk patients and switching to antiresorptive agents post-anabolic therapy if needed.
  • - The findings offer a cost-effective framework for osteoporosis management, emphasizing shared decision-making and integration of local healthcare systems to enhance patient care in the Asia-Pacific region.
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Unlabelled: A survey of awareness and attitudes to the management of fragility fractures among the membership of the Asia Pacific Orthopaedic Association conducted in 2022 found considerable variation in care across the region. A Call to Action is proposed to improve acute care, rehabilitation and secondary fracture prevention across Asia Pacific.

Purpose: Fragility fractures impose a substantial burden on older people and their families, healthcare systems and national economies.

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  • - The study investigates the connections between social isolation, depressed mood, and sarcopenia in older adults living in Taiwan, aiming to understand how social networks impact mental and physical health.
  • - Data from 981 community-dwelling older adults showed that around 15% had sarcopenia, with those lacking a strong social network and not meeting physical activity recommendations more likely to experience depressed mood and sarcopenia.
  • - Findings indicate that a poor social network significantly raises the risks of both depressed mood and sarcopenia in the elderly, emphasizing the importance of social connections for health in aging populations.
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  • A cross-sectional study was conducted in Taipei, Taiwan, to explore the relationship between frailty and sedentary behavior in older adults (65+ years) using various frailty criteria and sedentary behavior assessments.
  • The study involved 214 participants, revealing that frailer individuals tend to have longer total sedentary time and more frequent sedentary bouts, particularly when measured with the modified Fried Frailty Phenotype (mFFP) and Clinical Frailty Scale in Chinese Translation (CFS-C).
  • The research concluded that frailty is linked to an increased number of sedentary bouts, with significant differences in total sedentary time found only using specific frailty indices, indicating a need for further studies in this area.
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Background: The objective of this research was to report the trend of osteoporosis care after hip fractures from usual care (UC) and to compare the quality of care with those who received fracture liaison services (FLSs).

Methods: Data on osteoporosis care for patients with hip fracture were acquired from the National Health Insurance claims (UC group), and surveys from FLS programs (FLS group). A total of 183,300 patients receiving UC and 3010 patients receiving FLS were studied.

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Background: Osteoporosis is a common metabolic bone disease that benefits from many newly developed anti-osteoporosis medications (AOMs). Reimbursement policies need to allocate medical budgets properly based on evidence-based data. This study aimed to investigate the 11-year secular trend, focusing on older age and males in this adjustment wave of the National Health Insurance reimbursement.

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Background: The Bureau of National Health Insurance in Taiwan implemented a new reimbursement scheme incorporating bone mineral density (BMD) criteria on Jan. 1, 2011. This study aimed to investigate a real-life 11-year secular trend of adherence in new AOMs users and evaluated the change of adherence to AOMs therapy in different urbanization areas after reimbursement criteria were restrained.

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Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound. It can help improve bone fracture repair and soft tissue healing. Our previous study found that LIPUS treatment could halt the chronic kidney disease (CKD) progression in mice; unexpectedly, we observed the improvement of CKD-reduced muscle weights by LIPUS treatment.

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Background/purpose: Thirty-day hospital readmission rate significantly raised with advanced age. The performance of existing predictive models for readmission risk remained uncertain in the oldest population. We aimed to examine the effect of geriatric conditions and multimorbidity on readmission risk among older adults aged 80 and over.

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Background: Engaging in physical activity and reducing sedentary time in daily life may enable older individuals to maintain muscle mass. This study aimed to investigate the effects of replacing sedentary behavior with light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on the muscle function of older adults at a medical center in Taiwan.

Methods: We recruited 141 older adults (51.

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Background: The association of breaks in sedentary time with outcomes of physical function can vary according to the time of day. We examined the association of the diurnal pattern of breaks in sedentary time with physical function outcomes in older adults.

Methods: A cross-sectional analysis was conducted among 115 older adults (≥60 years).

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Osteoporosis greatly increases the risk of fractures. Osteoporotic fractures negatively impact quality of life, increase the burden of care, and increase mortality. Taiwan is an area with a high prevalence of osteoporosis.

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Postmenopausal women are at significant risk for osteoporotic fractures due to their rapid bone loss. Half of all postmenopausal women will get an osteoporosis-related fracture over their lifetime, with 25% developing a spine deformity and 15% developing a hip fracture. By 2050, more than half of all osteoporotic fractures will occur in Asia, with postmenopausal women being the most susceptible.

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Background: Healthcare-associated COVID-19 infections caused by SARS-CoV-2 have increased morbidity and mortality. Hospitals and skilled nursing facilities (SNFs) have been challenged by infection control and management.

Methods: This case study presents an outbreak investigation in a COVID-19-designated hospital and a hospital-based SNF.

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Article Synopsis
  • A study was conducted to explore urban-rural differences in outcomes related to vertebral fractures after participants received fracture liaison services (FLSs) and osteoporosis management.
  • Results showed that rural patients had a higher mortality rate, but both urban and rural groups had the same refracture rates within a year after treatment.
  • Although the types of osteoporosis medications were similar, rural participants exhibited lower medication adherence and were more likely to have additional health issues like chronic kidney disease and osteoarthritis.
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Low-intensity pulsed ultrasound (LIPUS), a therapeutic type of ultrasound, is known to enhance bone fracture repair processes and help some tissues to heal. Here, we investigated the therapeutic potential of LIPUS for the treatment of chronic kidney disease (CKD) in two CKD mouse models. CKD mice were induced using both unilateral renal ischemia/reperfusion injury (IRI) with nephrectomy and adenine administration.

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Tributyltin (TBT) is known as an endocrine-disrupting chemical. This study investigated the effects and possible mechanisms of TBT exposure on inducing human articular chondrocyte senescence in vitro at the human-relevant concentrations of 0.01-0.

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