The study investigated how mRNA expression of osteoclast-related factors changes in murine macrophages when exposed to nucleic acid from periodontal tissue of patients with chronic periodontitis.
Researchers extracted RNA from both inflammatory periodontal tissue and healthy gingival tissue to assess how macrophages react to these different types of tissue.
Results showed that exposure to the periodontitis patients' tissue nucleic acid significantly increased the mRNA levels of various osteoclast-related factors in the macrophages.