Glycolysis regulated exosomal LINC01214 inhibited CD8 T cell function and induced anti-PD1 resistance in melanoma via modulating miR-4492/PPP1R11 axis.

Background: Long non-coding RNAs (lncRNAs) can be incorporated into exosomes to mediate the intercellular communication, regulating the occurrence, development, and immunosuppression of cancers. T cell dysfunction has been a hallmark of many cancers, including melanoma, which enables cancer cells escape from host immune surveillance. However, the molecular mechanism of exosome-transmitted lncRNAs in CD8 T cell dysfunction in melanoma remains largely unclear.

Patient-reported gastrointestinal symptoms in gastric cancer after laparoscopic distal gastrectomy.

Purpose: This study aimed to compare postoperative gastrointestinal symptoms between patients who underwent laparoscopic distal gastrectomy with Roux-en-Y (R-Y) and Billroth-II with Braun (B-II B) reconstruction.

Methods: This observational study retrospectively analyzed 151 patients (110 in R-Y group and 41 in B-II B group) who underwent laparoscopic distal gastrectomy from January 2020 to December 2021. A comparison was made regarding surgical outcomes, perioperative nutritional and inflammatory markers, postoperative dietary patterns, and gastrointestinal symptoms between the two groups.

Bacterial diseases in Siniperca chuatsi: status and therapeutic strategies.

Mandarin fish (Siniperca chuatsi) is a prominent freshwater species with significant economic value in China, while disease poses a major hindrance to the advancement of mandarin fish aquaculture. To date, the understanding of the prevention and management of bacterial disease in mandarin fish remains incomplete. Therefore, there is a need for more comprehensive insights into the preventive and curative strategies to address these bacterial infections.

Enhancing ground loss rate prediction in soft-soil shield tunneling: a synergistic approach of peck back analysis and eXtreme Gradient Boosting and bayesian optimization.

This study investigates the prediction of ground loss rate during soft-soil shield tunneling using Peck's back analysis method and XGBoost model. Bayesian optimization is employed to determine optimal hyperparameters, ensuring comprehensive and efficient model tuning. The XGBoost model is compared with Random Forest (RF) and Support Vector Machine (SVM) models to benchmark its performance.

The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production.

Liver fibrosis/cirrhosis is a pathological state caused by excessive extracellular matrix deposition. Sustained activation of hepatic stellate cells (HSC) is the predominant cause of liver fibrosis, but the detailed mechanism is far from clear. In this study, we found that long noncoding RNA Fendrr is exclusively increased in hepatocytes in the murine model of CCl- and bile duct ligation-induced liver fibrosis, as well as in the biopsies of liver cirrhosis patients.

Prevalence of nontuberculous mycobacteria and the emergence of rare species in Henan Province, China.

Nontuberculous mycobacteria (NTM) is a large group of mycobacteria other than the complex and Epidemiological investigations have found that the incidence of NTM infections is increasing in China, and it is naturally resistant to many antibiotics. Therefore, studies of NTM species in clinical isolates are useful for understanding the epidemiology of NTM infections. The present study aimed to investigate the incidence of NTM infections and types of NTM species.

Metallofullerenol alleviates alcoholic liver damage via ROS clearance under static magnetic and electric fields.

Alcoholic liver disease (ALD) is a common chronic redox disease caused by increased alcohol consumption. Abstinence is a major challenge for people with alcohol dependence, and approved drugs have limited efficacy. Therefore, this study aimed to explore a new treatment strategy for ALD using ferroferric oxide endohedral fullerenol (FeO@C(OH)) in combination with static magnetic and electric fields (sBE).

Variation of the Start Date of the Vegetation Growing Season (SOS) and Its Climatic Drivers in the Tibetan Plateau.

Climate change inevitably affects vegetation growth in the Tibetan Plateau (TP). Understanding the dynamics of vegetation phenology and the responses of vegetation phenology to climate change are crucial for evaluating the impacts of climate change on terrestrial ecosystems. Despite many relevant studies conducted in the past, there still remain research gaps concerning the dominant factors that induce changes in the start date of the vegetation growing season (SOS).

Self-Powered Intelligent Water Droplet Monitoring Sensor Based on Solid-Liquid Triboelectric Nanogenerator.

Real-time monitoring of rainwater is a critical issue in the development of autonomous vehicles and smart homes, while the corresponding sensors play a pivotal role in ensuring their sensitivity. Here, we study a self-powered intelligent water droplet monitoring sensor based on a solid-liquid triboelectric nanogenerator (SL-TENG). The sensor comprises a SL-TENG, a signal acquisition module, a central processing unit (CPU), and a wireless transmission module, facilitating the real-time monitoring of water droplet signals.

Highly Sensitive Iontronic Pressure Sensor with Side-by-Side Package Based on Alveoli and Arch Structure.

Flexible pressure sensors play a significant role in wearable devices and electronic skin. Iontronic pressure sensors with high sensitivity, wide measurement range, and high resolution can meet requirements. Based on the significant deformation characteristics of alveoli to improve compressibility, and the ability of the arch to disperse vertical pressure into horizontal thrust to increase contact area, a graded hollow ball arch (GHBA) microstructure is proposed, greatly improving sensitivity.

A 3D-printed microhemispherical shell resonator with electrostatic tuning for a Coriolis vibratory gyroscope.

The emergence of microhemispherical resonant gyroscopes, which integrate the advantages of exceptional stability and long lifetime with miniaturization, has afforded new possibilities for the development of whole-angle gyroscopes. However, existing methods used for manufacturing microhemispherical resonant gyroscopes based on MEMS technology face the primary drawback of intricate and costly processing. Here, we report the design, fabrication, and characterization of the first 3D-printable microhemispherical shell resonator for a Coriolis vibrating gyroscope.

Plant-plant interactions vary greatly along a flooding gradient in a dam-induced riparian habitat.

Plant-plant interactions under extreme environmental stress are still controversial. The stress gradient hypothesis (SGH) proposes that facilitation prevails under extreme environmental stresses, while an alternative view states that facilitation collapses or even switches back to competition at the extreme end of stress gradients. However, how the relationship between plant-plant interaction and periodic extreme flooding stress varies and its underlying mechanism are still unclear in a dam-regulated riparian ecosystem.

Copy number variation of the restorer Rf4 underlies human selection of three-line hybrid rice breeding.

Cytoplasmic male sterility (CMS) lines are important for breeding hybrid crops, and utilization of CMS lines requires strong fertility restorer (Rf) genes. Rf4, a major Rf for Wild-Abortive CMS (CMS-WA), has been cloned in rice. However, the Rf4 evolution and formation of CMS-WA/Rf system remain elusive.

Segmental disturbance of white matter microstructure in predicting mild cognitive impairment in idiopathic Parkinson's disease: An individualized study based on automated fiber quantification tractography.

Purpose: The neurobiological mechanisms and an early identification of MCI in idiopathic Parkinson's disease (IPD) remain unclear. To investigate the abnormalities of types of white matter (WM) fiber tracts segmentally and establish reliable indicator in IPD-MCI.

Methods: Forty IPD with normal cognition (IPD-NCI), thirty IPD-MCI, and thirty healthy controls were included.

Long non-coding RNA CCHE1 modulates LDHA-mediated glycolysis and confers chemoresistance to melanoma cells.

Melanoma is considered as the most common metastatic skin cancer with increasing incidence and high mortality globally. The vital roles of long non-coding RNAs (lncRNAs) in the tumorigenesis of melanoma are elucidated by emerging evidence. The lncRNA cervical carcinoma high-expressed 1 (CCHE1) was overexpressed and acted as an oncogene in a variety of cancers, while the function of CCHE1 in melanoma remains unclear.

Long noncoding RNA AI662270 promotes kidney fibrosis through enhancing METTL3-mediated m A modification of CTGF mRNA.

The sustained release of profibrotic cytokines, mainly transforming growth factor-β (TGF-β), leads to the occurrence of kidney fibrosis and chronic kidney disease (CKD). Connective tissue growth factor (CTGF) appears to be an alternative target to TGF-β for antifibrotic therapy in CKD. In this study, we found that long noncoding RNA AI662270 was significantly increased in various renal fibrosis models.

Loss of EGFR contributes to high-fat diet-induced nonalcoholic fatty liver disease.

Using a murine model of high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD), we found that the expression of the epidermal growth factor receptor (EGFR) significantly decreased in hepatocytes. In vitro, free fatty acid influx decreased EGFR in hepatocytes. In HFD-fed mice, ectopic expression of EGFR alleviated intrahepatic lipid accumulation and reduced serum triglyceride and cholesterol, whereas knockdown of EGFR aggravated hepatic steatosis.

Increasing temperature regulates the advance of peak photosynthesis timing in the boreal ecosystem.

The shift in vegetation phenology is an essential indicator of global climate change. Numerous researches based on reflectance-based vegetation index data have explored the changes in the start (SOS) and end (EOS) of vegetation life events at long time scales, while a huge discrepancy existed between the phenological metrics of vegetation structure and function. The peak photosynthesis timing (PPT), which is crucial in regulating terrestrial ecosystem carbon balance, has not received much attention.

Restored vegetation is more resistant to extreme drought events than natural vegetation in Southwest China.

Large scale Ecosystem restoration projects (ERPs) have been implemented to restore vegetation and increase carbon stocks across China. However, whether restored vegetation is strongly resistant to Extreme drought events (EDEs) remains unclear, especially when compared to natural vegetation. Therefore, we used the standardized anomaly of 3-month Standard Precipitation-Evapotranspiration Index (SPEI) to characterize the spatial-temporal trends of EDEs, and figured out the capacity of restored vegetation to withstand the strongest EDE in Southwest China by analyzing their changes of Gross Primary Productivity (GPP) and Water Use Efficiency (WUE).

Nanosized Shikonin-Fe(III) Coordination Material for Synergistic Wound Treatment: An Initial Explorative Study.

Shikonin (Shik), a natural pigment, has received growing interest in various biomedical fields due to its anti-inflammatory, antitumor, antimicrobial, and antioxidant ability. However, some inherent characteristics of Shik, such as its virulence, low bioavailability, and poor solubility, have limited its biomedical applicability. Here, we reported a facile synthetic method to produce the Shik-iron (III) nanoparticles (Shik-Fe NPs), which could overcome these limitations of Shik.

A carbon monoxide releasing metal organic framework nanoplatform for synergistic treatment of triple-negative breast tumors.

Background: Carbon monoxide (CO) is an important signaling molecule participating in multiple biological functions. Previous studies have confirmed the valuable roles of CO in cancer therapies. If the CO concentration and distribution can be controlled in tumors, new cancer therapeutic strategy may be developed to benefit the patient survival.

Lodging resistance of rice plants studied from the perspective of culm mechanical properties, carbon framework, free volume, and chemical composition.

In this study, four varieties of rice were cultivated on the same farmland under same conditions and for same duration. However, their lodging resistance was found to be obviously different from each other. Herein, three key factors that highly influenced the lodging resistance were identified.

Light-acquisition traits link aboveground biomass and environment in inner saline-alkaline herbaceous marshes.

A functional response-effect approach could predict how environmental changes affect ecosystem functioning. However, few studies have applied this approach to inner saline-alkaline marsh ecosystems where soil saline-alkaline, flooding/drought and nutrients stresses threat ecological functioning. To disentangle the relationships between environmental conditions and ecosystem functioning, a total of 81 plots were investigated across 22 marsh sites dominated by Phragmites australis and Bolboschoenus planiculmis in Western Songnen Plain wetlands, China.

Patient-reported gastrointestinal symptoms following surgery for gastric cancer and the relative risk factors.

Purpose: The study aims to assess the incidence of short-term patient-reported postoperative gastrointestinal symptoms (PGISs) after gastric cancer surgery and explore the relative risk factors for the symptoms.

Methods: Patients with radical gastrectomy were included for this retrospective and observational study. Symptoms extracted from the MD Anderson Symptom Inventory Gastrointestinal Cancer Module (MDASI-GI) were collected in postdischarge week (PDW) 1 and postoperative month (POM) 1.

Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model.

Colchicine (Col) is used to prevent and treat acute gout flare; however, its therapeutic use is strictly limited owing to severe gastrointestinal side effects after oral administration. Therefore, we developed a dissolvable Col-loaded microneedle (MN) with hyaluronic acid to deliver Col the transdermal route. We studied the preparation, mechanical properties, skin insertion, skin irritation, drug content, and transdermal release of the Col-loaded MN.