Skilled reaching training combined with pharmacological inhibition of histone deacetylases potentiated motor recovery after intracerebral hemorrhage in a synergic manner.

Neuronal recovery after stroke is supported by the expression of genes involved in neuronal plasticity and neuroprotection. As an epigenetic modification, histone acetylation modulates gene expression elicited by neurorehabilitation. This study aimed to investigate the combined effects of skilled reaching training (SRT) and the pharmacological inhibition of histone deacetylase (HDAC) using sodium butyrate (NaB) on motor function recovery after intracerebral hemorrhage (ICH).

A Self-Priming Pyroptosis-Inducing Agent for Activating Anticancer Immunity.

Pyroptosis, a form of programmed cell death mediated by the gasdermin family, has emerged as a promising strategy for inducing anti-tumor immunity. However, efficiently inducing pyroptosis in tumor cells remains a significant challenge due to the limited activation of key mediators like caspases in tumor tissues. Herein, a self-priming pyroptosis-inducing agent (MnNZ@OMV) is developed by integrating outer membrane vesicles (OMVs) with manganese dioxide nanozymes (MnNZ) to trigger pyroptosis in tumor cells.

Effectiveness of glucocorticoids in preventing esophageal stricture and predictors of stricture after esophageal ESD: 5 years of experience in a single medical center.

Background: Esophageal stricture is one of the major complications after endoscopic submucosal dissection (ESD) of the esophagus. However, even with steroid prophylaxis, stenosis still occurs in up to 45% of patients. Accordingly, the aim of this study was to evaluate the efficacy and safety of steroid therapy in preventing esophageal strictures after ESD, as well as to assess the predictors of esophageal strictures after the application of steroids.

Total saponins from regulate the ferritin heavy chain to reduce inflammation in aging adipose tissue by mediating iron metabolism.

Background: Inflammation is a key factor contributing to aging-related morbidities. Inflammation is intimately linked to the iron metabolism in macrophages, and ferritin heavy chain (Fth) is the basis of iron metabolism in macrophages. Regulating Fth to control iron metabolism may help to reduce inflammation in macrophages, which can ultimately help to alleviate certain aging-related diseases.

Upper Gastrointestinal and Cutaneous Varicella in an Adult Male.

In this case report, we presented a unique instance of varicella in a 35-year-old male, characterized by both gastrointestinal and skin involvement. This case highlights the importance of recognizing varicella's atypical manifestations, particularly in adult patients with gastrointestinal symptoms, ensuring prompt diagnosis and appropriate management.

miR-107 suppresses porcine granulosa cell proliferation and estradiol synthesis while promoting apoptosis via targeting PTGS2.

The proliferation, steroid metabolism, and apoptosis of porcine ovarian granulosa cells (GCs) are critical for follicular development. MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene expression post-transcriptionally and modulate signaling networks involved in various cellular processes. In this study, we identify miR-107, a conserved miRNA, as a key regulator of porcine follicle development through its effects on GCs proliferation, steroid metabolism, and apoptosis.

Exploration of RNA-binding proteins identified RPS27 as a potential regulator associated with Kaposi's sarcoma development.

Background: Kaposi's sarcoma (KS) is a locally aggressive, multicentric tumor. RNA-binding proteins (RBPs) are pivotal for post-transcriptional regulation in various tumors. However, the aberrantly expressed RBP genes and their regulatory patterns in KS remain unclear.

Recyclable Supramolecular Nanofibrous Composite Membranes for Efficient Air Filtration.

Developing high-performance, low-resistance, and recyclable air filtration materials remains a formidable challenge. Herein, silica nanoparticles (SiO NPs) and supramolecular complexes consisting of melamine (MA) and trimesic acid (TMA) are constructed as SiO@MA·TMA supramolecular nanofibrous composite membrane via a thermally induced precursor process (TIPC) for efficient particulate matter (PM) removal. Hydrophilic SiO NPs as additional nucleation mediators can not only promote the growth of MA·TMA nanocrystalline fibers by shortening the interfacial free energy and thus reducing the nucleation barrier, but also increase fiber surface roughness thus constructing hierarchical structure of membrane.

An Integrated Virtual Screening Platform to Identify Potent Co-Assembled Nanodrugs for Cancer Treatment.

Co-assembled nanodrugs provide significant advantages in cancer treatment and drug delivery, yet effective screening methods to identify molecular combinations for co-assembly are lacking. This study presents a screening strategy integrating ligand-based virtual screening (LBVS) and density functional theory (DFT) calculations to explore new molecular combinations with co-assembly capabilities. The accuracy of this screening was validated by synthesizing various co-assembled nanodrugs under mild conditions.

Morphology and computational fluid dynamics support a novel classification of Spontaneous isolated superior mesenteric artery dissection.

Flow patterns and classification within Spontaneous Isolated Superior Mesenteric Artery Dissection (SISMAD) are crucial for selecting subsequent treatment options. This study aims to propose a new classification of SISMAD and to propose two corresponding treatment plans based on this new classification. The 3D models of 70 patients with SISMAD were reconstructed and classified into Li types I-V based on morphology, followed by computational fluid dynamics analysis.

Chemical constituents and their anti-ferroptosis activities of Ajuga bracteosa.

Two new abietane diterpenoids (1 and 2), along with twelve known compounds (3-14), were isolated from the whole plants of Ajuga bracteosa. Their structures were elucidated through a combination of spectroscopic analyses, including NMR and ECD calculations. All isolates were evaluated for their inhibitory effects on RSL3-induced ferroptosis in HT22 cells.

Integration of Methylation and Gene Expression Deciphered Candidate Biomarkers DAB2IP and SMYD3 in Delayed Encephalopathy After Carbon Monoxide Poisoning.

Aims: The objective of this study is to explore the regulatory role of DNA methylation in delayed encephalopathy after carbon monoxide poisoning (DEACMP) and to identify candidate epigenetic biomarkers.

Methods: In this study, multi-omics analyses such as methylomics, transcriptomics, pyrophosphate sequencing, qRT-PCR, immunohistochemistry, and western blotting were utilized to investigate the role of epigenetic regulation and altered gene expression in the pathogenesis of DEACMP.

Results: Using integrated analysis, we identified 168 differentially methylated CpGs sites, 334 differentially expressed genes, and two differentially methylated and differentially expressed genes (DAB2IP and SMYD3) in the DEACMP group.

Control engineering for the construction of UiO-66 effectively increases adsorption performance: The role of solvent factor.

Controlled synthesis based on the metal-organic skeleton structure and channel size is essential for practical applications. In addition to adjusting structural characteristics, it is crucial to reveal the relationship between morphology and properties in chemistry to achieve rational material design. This paper investigates the effects of the proton supply/acceptor capacity (β/α parameter) on the structure of Zr-MOF and the adsorption properties of Sb(V) in UiO-66-X (University of Oslo-66) crystal material constructed with a variety of solvents as templates, using the Kamlet-Taft method.

Preparation and performance analysis of zinc-iron-based nanomaterials for targeted transport.

Background: Nanomaterials have applications in traditional Chinese medicine in the fields of medical equipment manufacturing, targeted transportation, and drug synergistic therapy.

Objective: The research aims to discuss the performance and performance of zinc-iron-based nanomaterials in medical drug delivery and synergistic drug therapy.

Methods: Using Prussian materials as precursors, magnetic zinc-iron nanomaterials were prepared by ZnCl and K[Fe (CN)].

Characteristics of Skin Lesions Determine the Therapeutic Response of Facial Café Au Lait Macules Laser Therapy.

Background: The efficacy of laser treatment for facial café au lait macules (CALMs) is random.

Aim: To compare the response of different characteristics of CALMs skin lesions to laser treatment.

Patients/methods: In this single-center retrospective case series, patients with café au lait macules who received laser treatment between 2015 and 2022 at our clinic were reviewed.

Case report: Clinical characteristics and Genetical analysis of in three Chinese children with apparent mineralocorticoid excess: a case series.

Background: Apparent Mineralocorticoid Excess (AME) is a rare autosomal recessive disorder, characterized by a notably complex diagnostic process. To date, the majority of documented cases have been presented as individual case reports. This article aims to enhance the understanding of the course and prognosis of AME, by detailing the management protocols employed for patients with genetically confirmed diagnoses.

The Moonlighting Function of Glutamin Synthase 2 Promotes Immune Evasion of Pancreatic Ductal Adenocarcinoma by Tubulin Tyrosine Ligase-like 1-Mediated Yes1 Associated Transcriptional Regulator Glutamylation.

Background And Aims: Elevated PD-L1 expression in tumor cells facilitates immune evasion. However, the mechanism via which PD-L1 expression is regulated in pancreatic ductal adenocarcinoma (PDAC) cells remains inadequately elucidated.

Methods: Immunoprecipitation, pull-down assays, and mass spectrometry were used to identify glutamine synthase 2 (GLS2) and yes1 associated transcriptional regulator (YAP1) binding proteins and modification sites.

Molecular self-assembly strategy tuning a dry crosslinking protein patch for biocompatible and biodegradable haemostatic sealing.

Uncontrolled haemorrhage is a leading cause of trauma-related fatalities, highlighting the critical need for rapid and effective haemostasis. Current haemostatic materials encounter limitations such as slow clotting and weak mechanical strength, while most of bioadhesives compromise their adhesion performance to wet tissues for biocompatibility and degradability. In this study, a molecular self-assembly strategy is proposed, developing a biocompatible and biodegradable protein-based patch with excellent adhesion performance.

Drug-induced autoimmune-like hepatitis: A disproportionality analysis based on the FAERS database.

Background: Drug-induced autoimmune-like hepatitis (DI-ALH) is a potentially life-threatening condition that can lead to acute liver failure and necessitate liver transplantation. While the association between certain drugs and DI-ALH has been documented, a comprehensive analysis of drug-related signals in a large, real-world pharmacovigilance database is lacking. This study aimed to systematically identify drugs linked to DI-ALH by analyzing adverse event reports from the U.

Adult split liver transplantation to treat liver cancer: a single-center retrospective study.

Background: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation (SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy of SLT are still controversial.

Insulin autoimmune syndrome in a 3-year-old boy: the youngest to date in China and a narrow review.

Background: Insulin autoimmune syndrome (IAS), characterized by endogenous hypoglycemia associated with insulin autoantibodies, is a rare cause of hypoglycemia in pediatric patients. Here, we report a case of the youngest patient with IAS in China, and summarize the clinical characteristics of the disease through a narrow review of pediatric cases.

Case Presentation: A 3-year-10-month-old Chinese boy presented with unconsciousness.

Comparison of percutaneous versus cutdown access in patients after endovascular abdominal aortic repair: a randomized controlled trial (SWEET-EVAR trial).

Introduction: The optimal choice of either percutaneous or cutdown access for endovascular abdominal aortic repair (EVAR) remains uncertain due to insufficient evidence, particularly regarding patient-centered outcomes (PCOs). This study aimed at comparing both clinician-reported outcomes (ClinROs) and PCOs of percutaneous versus cutdown access in patients after EVAR.

Methods: The study was a single-blind, single-center, non-inferiority, randomized controlled trial.

Biomimetic Nanostructure Engineering of Ultralow Ir-Loading Electrocatalysts for Oxygen Reduction Reaction.

Promoting the rate of the oxygen reduction reaction (ORR) is critical for boosting the overall energy efficiency of the flexible zinc-air batteries (FZABs). Inspired by nature, we designed "branch-leaf" like hierarchical porous carbon nanofibers with ultralow loadings of Ir nanoparticles (NPs) derived from covalent-organic framework/metal-organic framework (COF/MOF) core-shell hybrids. The as-obtained Ir/FeZn-hierarchical porous carbon nanofibers (HPCNFs) showcase enhanced ORR performance, and the ultralow Ir loading reduces the cost while maintaining catalytic capacity.

Total saponins from Panax japonicus reduced lipid deposition and inflammation in hepatocyte via PHD2 and hepatic macrophage-derived exosomal miR-463-5p.

Ethnopharmacological Relevance: Panax japonicus (T. Nees) C.A.

Relationship between trait mindfulness and physical activity among emerging adults: The mediating roles of exercise-related cognitive errors and trait self-control.

Objective: Exercise-related cognitive errors (ECEs) is a significant factor that can negatively influence physical activity (PA) engagement among emerging adults, whereas mindfulness interventions may be beneficial for promoting PA. Against this background, we investigated the potential association between trait mindfulness and PA levels among emerging adults and determined whether trait self-control and ECEs serve as mediators.

Method: 328 Chinese participants (61.