Conditionally activated immunotoxins with prolonged half-life can enhance the anti-tumor activity.

Immunotoxin has become a highly promising therapy for treating cancer and has achieved good results in preclinical trials targeting various cancers. However, there are still some issues that limit the development and application of immunotoxins, such as short half-life and toxic side effects on healthy tissues. In this study, we designed a tumor-conditional immunotoxin called Nb-uPA-A1-PE24.

Hydrogel-to-Nanoparticle Transition with Immune Cell Activation Controlled by Dual Supramolecular Interactions.

Biomolecules may undergo dynamic transitions between different aggregation states in order to adapt to the microenvironment. As a result, appropriate biofunctions can be performed only under certain states. This feature inspires exploration for constructing and regulating environmentally adaptive materials through supramolecular ways.

Swine RNF5 positively regulates the antiviral activity of IFITM1 by mediating the degradation of ABHD16A.

Unlabelled: Interferon-inducible transmembrane (IFITM) proteins are broad-spectrum antiviral factors that confer cellular resistance to virus invasion. α/β-Hydrolase domain-containing 16A (ABHD16A) has recently been identified as a novel depalmitoylase that can inhibit the antiviral activity of IFITM proteins by catalyzing the depalmitoyl reaction; this pattern may be crucial for the host to avoid damage caused by excessive immune response. However, it remains largely elusive about how host cells regulate the activity of ABHD16A.

AER-Net: Attention-Enhanced Residual Refinement Network for Nuclei Segmentation and Classification in Histology Images.

The acurate segmentation and classification of nuclei in histological images are crucial for the diagnosis and treatment of colorectal cancer. However, the aggregation of nuclei and intra-class variability in histology images present significant challenges for nuclei segmentation and classification. In addition, the imbalance of various nuclei classes exacerbates the difficulty of nuclei classification and segmentation using deep learning models.

Functional Divergence of the Closely Related Genes PhARF5 and PhARF19a in Flower Formation and Hormone Signaling.

The ARF gene family plays a vital role in regulating multiple aspects of plant growth and development. However, detailed research on the role of the ARF family in regulating flower development in petunia and other plants remains limited. This study investigates the distinct roles of and in flower development.

The Gene Cluster - Negatively Regulates Biofilm Formation in .

() is a zoonotic foodborne pathogen that is widely distributed worldwide. Its optimal growth environment is microaerophilic conditions (5% O, 10% CO), but it can spread widely in the atmospheric environment. Biofilms are thought to play an important role in this process.

Anthropomorphic Design in Mortality Salience Situations: Exploring Emotional and Non-Emotional Mechanisms Enhancing Consumer Purchase Intentions.

This study investigates the role of anthropomorphic design in alleviating consumer anxiety induced by mortality salience and delves into the underlying emotional and non-emotional mechanisms. Through a series of meticulously designed experiments, we confirm that anthropomorphic design significantly enhances positive emotional responses in consumers, reduces negative emotions, and thereby increases their preference and willingness to purchase products. Even after the diminution of emotional reactions, anthropomorphic design continues to sustain consumer preference by enhancing psychological intimacy.

Mechanochromic Organic Micro-Laser.

This work presents the first demonstration of a mechanochromic organic micro-laser, which exhibits remarkable wide range pressure sensing characteristics. The gain material, pinacolato boronate ester functionalized anthanthrene (AnBPin), is designed by incorporating mechanofluorochromic (MFC) properties into organic laser dye. The AnBPin exhibits a reversible transition between green and orange fluorescence upon grinding annealing and recrystallization cycle, and its micro-crystal exhibits typical organic micro-laser behaviors.

FeO/Mulberry Stem Biochar as a Potential Amendment for Highly Arsenic-Contaminated Paddy Soil Remediation.

Magnetite-loaded biochar has recently received attention owing to its ability to remove arsenic from contaminated soil. In this study, mulberry stem biochar (MBC) and FeO-loaded mulberry stem biochar (FeO@MBC) were produced and used in a 100-day incubation experiment to investigate their performance in the stabilization of arsenic in paddy soil severely polluted by the As (237.68 mg·kg) mechanism.

Transplantation of human neural stem cells repairs neural circuits and restores neurological function in the stroke-injured brain.

Exogenous neural stem cell (NSC) transplantation has become one of the most promising treatment methods for chronic stroke. Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury, which limits the ability to observe long-term behavioral recovery. Here, we used a severe stroke rat model with 150 minutes of ischemia, which produced severe behavioral deficiencies that persisted at 12 weeks, to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.

Copper-Mediated Cross-Coupling Selective for Pyroglutamate Post-Translational Modifications.

Pyroglutamate is a cyclic -terminal post-translational modification that occurs in both proteins and peptide hormones. The prevalence and biological roles of pyroglutamate are little understood, in part due to limited tools to identify, quantify, and manipulate its pyrrolidinone structure. Selective modification of pyroglutamate residues in complex polypeptides may provide unique tools to better understand its biological roles and to allow late-stage diversification of biologically active pyroglutamate-containing sequences.

Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study.

Background: Helicobacter pylori (Hp) infection and metabolic syndrome (MetS) have a high prevalence of co-morbidities and both pose a significant threat to human health and survival. It has been suggested that Hp infection affects the development of MetS in the host, but the causal relationship between the two has not been confirmed.

Methods: We conducted a two-sample Mendelian randomization study to investigate the causal effect of Hp infection with MetS and its components.

A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia.

Refractoriness to initial chemotherapy and relapse after remission are the main obstacles to curing T cell acute lymphoblastic leukemia (T-ALL). While tumor heterogeneity has been implicated in treatment failure, the cellular and genetic factors contributing to resistance and relapse remain unknown. Here we linked tumor subpopulations with clinical outcome, created an atlas of healthy pediatric hematopoiesis and applied single-cell multiomic analysis to a diverse cohort of 40 T-ALL cases.

A study to reveal the synergistic bacteriostatic potential of egg white lysozyme with carvacrol at the molecular level.

The modification of proteins by bioactive molecules may have a synergistic enhancement effect on their respective functional properties. In this study, carvacrol (Car) was used to modify egg white lysozyme (LYZ) to improve its bacteriostatic ability. The results of microbiological experiments suggested that LYZ modified with Car had enhanced bacteriostatic activity against Escherichia coli (E.

Digital technology and Chinese-style industrial modernization: Dynamic threshold effect based on R&D Human resources.

Based on the construction of digital technology evaluation index system, this paper builds a dynamic threshold regression model to explore the complex impact of digital technology on Chinese-style industrial modernization under the threshold of R&D human resources, taking 30 provinces as research objects. It has been found that China's digital technology index is continuously improving, but there is a digital gap among regions. The beneficial impact of digital technology on Chinese-style industrial modernization has been thoroughly validated.

From OCD Symptoms to Sleep Disorders: The Crucial Role of Vitamin B12.

Objective: Vitamin B12 is crucial for neurological functions and linked to various psychiatric disorders. Given its importance, this study explores the impact of vitamin B12 deficiency on sleep quality in Obsessive-Compulsive Disorder (OCD) patients, while also examining folate and homocysteine levels to explore their potential interactions with OCD symptoms and sleep quality.

Methods: This cross-sectional study included 52 patients with OCD and 42 healthy controls.

Video- assisted thoracoscopic lung resection with or without enhanced recovery after surgery: a single institution, prospective randomized controlled study.

Purpose: This study was conducted to evaluate the postoperative short-term outcomes of patients undergoing video-assisted thoracoscopic surgery (VATS) for lung resection with the enhanced recovery after surgery (ERAS) protocol.

Methods: A single-institution, prospective randomized controlled study was conducted. The primary outcome measures were postoperative pulmonary complications (PPCs) and postoperative short-term effects.

An ionic-liquid functionalized metal-organic framework and its high performance as a solid electrolyte for lithium-ion conduction.

Crystalline porous metal-organic frameworks (MOFs) have attracted great interest, including in the field of solid-state electrolytes. Herein, we report a new type of solid-state electrolyte based on an MOF matrix and a Li ionic liquid. By covalently bonding the Li ionic liquid (MIMS·LiTFSI) on the stable UiO-67 framework, the obtained crystalline IL-MOF material exhibited high ion conductivities within a wide temperature range (30 °C 1.

Identification and characterization of a novel bacteriocin PCM7-4 and its antimicrobial activity against Listeria monocytogenes.

Listeria monocytogenes, a pathogenic bacterium causing zoonotic diseases, necessitates the urgent search for novel anti-Listeria monocytogenes drugs due to the continuous emergence of drug-resistant bacteria. In this study, we isolated and identified a bacteriocin-producing strain CM7-4 from seawater as Bacillus velezensis through 16S rRNA sequence analysis. Moreover, we successfully purified a novel bacteriocin named PCM7-4 from Bacillus velezensis CM7-4.