The Trend in Delayed Childbearing Age and Its Potential Impact on Adverse Maternal-Perinatal Outcomes in Developed and Developing Countries: A Narrative Review.

Due to the significant advancement of modern societies, higher education, career growth, and economic independence, more young girls are likely to delay childbearing beyond 30 years of age. The trend of delayed childbearing is more pronounced in industrialized countries but is also becoming common in emerging countries. Delayed childbearing has been linked with several adverse maternal-perinatal outcomes, including hypertensive disorders of pregnancy, abnormal placentation, gestational diabetes mellitus, pre-term births, low birthweight, perinatal mortality, congenital birth defects, and chromosomal abnormalities.

Network analysis of the hair-based nine hormones from four neuroendocrine systems.

Introduction: The stress response maintains the homeostasis of the body's internal environment and normal physiological activities, involving several neuroendocrine systems, such as the HPA axis, the HPG axis, the endocannabinoid system, and the melatonin system. However, studies on the intricate interactions among the four neuroendocrine systems are lacking, and it is not clear how these interactions are affected by demographic variables. The aim of this study was to investigate the network characteristics of hormonal networks comprising nine hormones from four neuroendocrine systems and how they were affected by demographic variables.

Safety and Effectiveness Outcomes between Apixaban Versus Vitamin K Antagonists in Atrial Fibrillation Patients on Dialysis.

Background: Anticoagulant therapy for atrial fibrillation (AF) in patients with end-stage kidney disease (ESKD) undergoing dialysis poses significant challenges. This review aimed to furnish clinicians with the latest clinical outcomes associated with apixaban and vitamin K antagonists (VKAs) in managing AF patients on dialysis.

Methods: Literature from the PubMed and Embase databases up to March 2024 underwent systematic scrutiny for inclusion.

A case report of breast cancer metastasis to the bladder from invasive ductal carcinoma.

Introduction And Importance: Breast cancer is the most common malignancy among women worldwide, predominantly manifesting as invasive ductal carcinoma (IDC), which usually metastasizes to the bones, lungs, and liver. However, metastasis to the bladder is exceedingly rare, with few documented cases and limited understanding in the existing literature.

Case Presentation: A 57-year-old woman with a history of IDC presented with a lump in her left breast and was initially treated with chemotherapy and a modified radical mastectomy.

Isoliquiritigenin alleviates experimental autoimmune encephalomyelitis by modulating inflammatory and neuroprotective reactive astrocytes.

Multiple sclerosis (MS) is an autoimmune-mediated chronic inflammatory demyelinating disease of the central nervous system (CNS) that poses significant treatment challenges. Currently, it is believed that inflammatory and neuroprotective reactive astrocytes, along with other resident CNS cells and immune cells, contribute to the pathophysiology of MS. In our study, we found that isoliquiritigenin (ILG), a bioactive chalcone compound, significantly reduces the clinical scores of experimental autoimmune encephalomyelitis (EAE) by 44 % (P < 0.

Daphnetin protects neurons in an Alzheimer disease mouse model and normal rat neurons by inhibiting BACE1 activity and activating the Nrf2/HO-1 pathway.

The common neurodegenerative disorder Alzheimer disease (AD) is characterized by memory dysfunction and cognitive decline in the elderly. Neuropathological features include aggregated β-amyloid (Aβ) accumulation, neuroinflammation, and oxidative stress in the brain. Daphnetin (DAPH), a natural coumarin derivative, has the potential for inhibiting inflammatory and oxidative responses.

Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studies.

Background: Since the association of vitamin D with atrial fibrillation (AF) risk is still unclear, we conducted this updated meta-analysis of prospective studies to identify the relationship between vitamin D or vitamin D supplementation and AF in the general population.

Methods: We conducted a comprehensive search of multiple databases up to May 2023 for studies reporting vitamin D and AF. The hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled by a random-effects model.

Immediate breast reconstruction with laparoscopically harvested omental flap: A retrospective analysis with a maximum 12-year follow-up.

Purpose: To evaluate the clinical efficacy of immediate breast reconstruction with free or pedicled laparoscopically harvested omental flaps (LHOFs).

Methods: Between March 2011 and 2021, 82 patients who underwent immediate breast reconstruction with free or pediculated omental flaps were enrolled. Breast total or partial mastectomy, laparoscopic greater omentum harvest, and breast reconstruction were carried out in an orderly manner.

The association between dietary intake of flavonoids and its subclasses and the risk of metabolic syndrome.

Background: The healthiest way to prevent metabolic syndrome (MetS) is through behavioral and nutritional adjustments. We examined the relationship between total flavonoids intake, flavonoid subclasses, and clinically manifest MetS.

Methods: A cross-sectional analysis was conducted among 28,719 individuals from the National Health and Nutrition Examination Survey (NHANES) and Food and Nutrient Database for Dietary Studies (FNDDS) 2007-2011 and 2017-2018.

Comparison of the combined use of CNV-seq and karyotyping or QF-PCR in prenatal diagnosis: a retrospective study.

To elevate the accuracy of diagnostic results, CNV-seq is usually performed simultaneously with karyotyping or QF-PCR. Although several studies have investigated the performance of the combined use of CNV-seq with karyotyping or QF-PCR, there have been no reports focusing on the comparison of these 2 diagnostic strategies. In our study, 2507 pregnant women were included to investigate these 2 strategies.

Identification of highly effective inhibitors against SARS-CoV-2 main protease: From virtual screening to in vitro study.

The public's safety has been significantly jeopardized by the pandemic of COVID-19, which is brought on by the highly virulent and contagious SARS-CoV-2 virus. Finding novel antiviral drugs is currently of utmost importance for the treatment of patients with COVID-19. Main protease (3CL) of SARS-CoV-2 is involved in replication of virus, so it is considered as a promising target.

Clinical Application of Evoked Potentials in the Operation of Cervical Spondylotic Myelopathy with Different Imaging.

Objective: To observe the effects of improvement of cervical spondylotic myelopathy with different imaging signals after cortical somatosensory-evoked potentials on the functional recovery of postoperative patients and the effect of surgery.

Methods: A total of 60 patients with cervical spondylotic myelopathy who were hospitalized in our hospital from January 2020 to December 2020 were selected and divided into a case group (30 cases) with MRI-indicated changes in intramedullary signals and a control group (30 cases) with MRI-indicated spinal cord changes. Intragroup and intergroup control studies were conducted through general observation indexes, neurological evaluation indexes, imaging, and evoked potential observation indexes.

EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.

Objective: This study was designed to explore the role and mechanism of eukaryotic initiation factor 3C (EIF3C) in the proliferation and apoptosis of lung cancer cells.

Methods: EIF3C expression in clinic lung cancer tissues was detected by immunohistochemistry assay. Cell transfection with lentivirus EIF3C short hairpin RNA (shRNA) was performed with Lipofectamine 2000.

[Effect and mechanism of leonurine on pressure overload-induced cardiac hypertrophy in rats].

To investigate the effects of leonurine(Leo) on abdominal aortic constriction(AAC)-induced cardiac hypertrophy in rats and its mechanism. A rat model of pressure overload-induced cardiac hypertrophy was established by AAC method. After 27-d intervention with high-dose(30 mg·kg~(-1)) and low-dose(15 mg·kg~(-1)) Leo or positive control drug losartan(5 mg·kg~(-1)), the cardiac function was evaluated by hemodynamic method, followed by the recording of left ventricular systolic pressure(LVSP), left ventricular end-diastolic pressure(LVESP), as well as the maximum rate of increase and decrease in left ventricular pressure(±dp/dt_(max)).

Verification of Volume Similarity Between Unilateral Mammary Gland and Autologous Omentum in Adult Women by Measuring Cylinder Method.

Objective: To verify the volume similarity between unilateral mammary gland and autologous omentum in adult females.

Methods: A total of 63 patients diagnosed with stage 0-II breast cancer and partial non-lactating multi-fistula mastitis in the breast surgery department of Inner Mongolia Xing'an League People's Hospital from 2007 to 2020 were enrolled in the study, including 52 cases of stage 0-II breast cancer and 11 cases of non-lactating multi-fistula mastitis. The volume of the resected mammary gland and the omentum were measured by a "soft tissue measuring cylinder" and recorded.

The Discovery of Potential MDM2 Inhibitors: A Combination of Pharmacophore Modeling, Virtual Screening, Molecular Docking Studies, and in vitro/in vivo Biological Evaluation.

Small-molecule inhibitors of MDM2 that block the MDM2-p53 protein-protein interaction have been considered as potential therapeutic agents for the treatment of cancer. Here, we identify five highly potent inhibitors of MDM2 (termed as WY 1-5) that display significant inhibitory effects on MDM2-p53 interaction by using a combined strategy of pharmacophore modeling, virtual screening, and molecular docking studies. Among them, WY-5 is the most active MDM2 inhibitor with an IC value of 14.

Design of Lubricant-Infused Surfaces Based on Mussel-Inspired Nanosilica Coatings: Solving Adhesion by Pre-Adhesion.

Slippery liquid-infused porous surfaces (SLIPSs) have attracted wide interest with regard to their excellent liquid repellency properties and broad applications in various fields associated with anti-adhesion. However, the preparation processes depending on the chemical properties of the substrate and the poor stability of the lubricant layer hinder the practical applications. In this work, a facile method to fabricate SLIPSs based on the mussel-inspired polydopamine (PDA)-mediated nanosilica structures is demonstrated.

Non-vitamin K antagonist oral anticoagulants versus vitamin K antagonists in atrial fibrillation patients with previous stroke or intracranial hemorrhage: A systematic review and meta-analysis of observational studies.

Several observational studies have compared the effectiveness and safety outcomes between nonvitamin K antagonist oral anticoagulants (NOACs) and vitamin K antagonists (VKAs) in atrial fibrillation (AF) patients with a history of either stroke/transient ischemic attack (TIA) or intracranial hemorrhage. Therefore, our current meta-analysis aimed to address this issue. The Cochrane Library, PubMed, and Embase databases were systematically searched until December 2020 for all relevant observational studies.

Treatment of Degenerative Lumbar Scoliosis with Oblique Lumbar Interbody Fusion in Conjunction with Unilateral Pedicle Screw Fixation via the Wiltse Approach.

Objective: To evaluate the clinical outcomes of oblique lumbar interbody fusion (OLIF) in conjunction with unilateral pedicle screw fixation (UPSF) via the Wiltse approach in treating degenerative lumbar scoliosis (DLS).

Methods: The article is a retrospective analysis. Twelve patients with DLS who underwent combined OLIF and UPSF between July 2017 and December 2018 were included.

Transcriptomic analyses reveal dynamic changes of defense response in Glycyrrhiza uralensis leaves under enhanced ultraviolet-B radiation.

The amount of solar ultraviolet-B (UV-B) radiation reaching the Earth's surface is increasing due to stratospheric ozone dynamics and global climate change. Increased UV-B radiation poses a major threat to ecosystems. Although many studies have focused on the potential effects of enhanced UV-B radiation on plants, the dynamic changes of defense response in plants under continuous UV-B radiation remains enigmatic.

[Analysis of clinical characteristics of 87 patients with cochlear migraine].

The aim of this study is to analyze the clinical features of cochlear migraine. The clinical data of cases of cochlear migraine were collected, and the clinical symptoms and hearing examination results were analyzed. The ratio of male to female patients with cochlear migraine was 1∶3.

Mechanism for the reactivation of the peroxidase activity of human cyclooxygenases: investigation using phenol as a reducing cosubstrate.

It has been known for many years that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro by the presence of phenol, which serves as a reducing compound, but the underlying mechanism is still poorly understood. In the present study, we use phenol as a model compound to investigate the mechanism by which the peroxidase activity of human COXs is reactivated after each catalytic cycle. Molecular docking and quantum mechanics calculations are carried out to probe the interaction of phenol with the peroxidase site of COXs and the reactivation mechanism.

Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis.

Background: Neuromyelitis optica spectrum disorder (NMOSD), an autoimmune astrocytopathic disease associated with the anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions primarily located on the optic nerves and spinal cord. Tanshinone IIA (TSA), an active natural compound extracted from Salvia miltiorrhiza Bunge, has profound immunosuppressive effects on neutrophils.

Objective: The present study aimed to evaluate the effect of TSA on NMOSD mice and explore the underlying mechanisms.

Activity-Tuning of Supported Co-Ni Nanocatalysts via Composition and Morphology for Hydrogen Storage in MgH.

Developing cheap metal nanocatalysts with controllable catalytic activity is one of the critical challenges for improving hydrogen storage in magnesium (Mg). Here, it is shown that the activity of graphene-anchored Co-Ni nanocatalysts can be regulated effectively by tuning their composition and morphology, which results in significantly improved hydrogen storage in Mg. The catalytic activity of supported Co-Ni nanocatalysts is demonstrated to be highly dependent on their morphology and composition.