MicroRNA-21 was a promising biomarker for lung carcinoma diagnosis: An update meta-analysis.

Objective: To investigate the diagnostic performance of microRNA-21 detected in serum or sputum as a biomarker for lung carcinoma identification through pooling the open published data.

Methods: Clinical diagnostic studies related to microRNA-21 as a biomarker for lung carcinoma identification were electronically searched in the databases of Pubmed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and Google Scholar. The data of the included studies was extracted and made pooling of diagnostic sensitivity, specificity, diagnostic odds ratio (DOR), area under the summary receiver operating characteristic curve (ROC) (AUC) for microRNA-21 expression in serum or sputum as a biomarker for lung carcinoma identification.

Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity.

The approval of immune checkpoint inhibitors has expanded treatment options for renal cell carcinoma (RCC), but new therapies that target RCC stemness and promote anti-tumor immunity are needed. Previous findings demonstrate that doublecortin-like kinase 1 (DCLK1) regulates stemness and is associated with RCC disease progression. Herein, we demonstrate that small-molecule kinase inhibitor DCLK1-IN-1 strongly inhibits DCLK1 phosphorylation and downregulates pluripotency factors and cancer stem cell (CSC) or epithelial-mesenchymal transition (EMT)-associated markers including c-MET, c-MYC, and N-Cadherin in RCC cell lines.

Preferential siRNA delivery to injured kidneys for combination treatment of acute kidney injury.

Acute kidney injury (AKI) is characterized by a sudden loss of renal function and is associated with high morbidity and mortality. Tumor suppressor p53 and chemokine receptor CXCR4 were both implicated in the AKI pathology. Here, we report on the development and evaluation of polymeric CXCR4 antagonist (PCX) siRNA carrier for selective delivery to injured kidneys in AKI.

HCl-Catalyzed Aerobic Oxidation of Alkylarenes to Carbonyls.

The construction of C-O bonds through C-H bond functionalization remains fundamentally challenging. Here, a practical chlorine radical-mediated aerobic oxidation of alkylarenes to carbonyls was developed. This protocol employed commercially available HCl as a hydrogen atom transfer (HAT) reagent and air as a sustainable oxidant.

Preparation of novel porous AlO-SiOnanocomposites via solution-freeze-drying-calcination method for the efficient removal of uranium in solution.

In this work, the efficient extraction of uranium in solution using AlO-SiO-T was reported. Kinetics and isotherm models indicated that the removal process of uranium on AlO-SiO-T accorded with pseudo-second-order kinetic model and Langmuir isotherm model, which showed that the adsorption process was a uniform mono-layer chemical behavior. The maximum adsorption capacity of AlO-SiO-T reached 738.

Evaluation and application of a positively-charged phenylaminopropyl bonded stationary phase for separation of basic compounds.

Silica-based positively-charged stationary phase bonding phenylaminopropyl (named PHN) was found to produce symmetrical peak shape and higher sample loading for basic compounds. In this work, firstly, surface charge property of the PHN was evaluated by ζ-potential and retention of NO. A considerable amount of pH-dependent positive charges was confirmed more than that on CSH Phenyl-Hexyl, a commercial positively-charged phenyl stationary phase.

Nomogram for the Prediction of 30-Day Readmission in Acute Pancreatitis.

Background: A prediction model for 30-day readmission in patients with acute pancreatitis (AP) was needed.

Aims: To develop a nomogram to predict 30-day readmission in patients with AP and validate the usefulness of serum indicators after discharge for the prediction of 30-day readmission.

Methods: This was a retrospective cohort study enrolling patients with the first attack of AP.

Intraperitoneal siRNA Nanoparticles for Augmentation of Gemcitabine Efficacy in the Treatment of Pancreatic Cancer.

Pancreatic ductal adenocarcinoma is a deadly disease with limited treatment options due to late diagnosis and resistance to conventional chemotherapy. Among emerging therapeutic targets, the CXCR4 chemokine receptor and polo-like kinase 1 (PLK1) play critical roles in the progression, metastasis, and chemoresistance of pancreatic cancer. Here, we tested the hypothesis that combining CXCR4 inhibition by a polymeric CXCR4 antagonist PAMD-CHOL with PLK1 knockdown by siRNA will enhance the therapeutic effect of gemcitabine (GEM) in the orthotopic model of metastatic pancreatic cancer.

Effect of Acid-Etching Duration on the Adhesive Performance of Printed Polyetheretherketone to Veneering Resin.

Three-dimensional printing polyetheretherketone (PEEK) provides a new choice for dental prostheses, while its appropriate bonding procedure and adhesive performance are still unclear. This study aimed to investigate the adhesive performance of printed polyetheretherketone (PEEK) after acid etching to veneering resin. In total, 182 PEEK specimens (including 91 printed and 91 milled specimens) were distributed to 14 subgroups ( = 13/subgroup), according to the manufacturing process and surface treatment.

Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in people younger than 18 years: a randomised, double-blind, controlled, phase 1/2 trial.

Background: Although SARS-CoV-2 infection often causes milder symptoms in children and adolescents, young people might still play a key part in SARS-CoV-2 transmission. An efficacious vaccine for children and adolescents could therefore assist pandemic control. For further evaluation of the inactivated COVID-19 vaccine candidate BBIBP-CorV, we assessed the safety and immunogenicity of BBIBP-CorV in participants aged 3-17 years.

Photodegradation of microplastics mediated by different types of soil: The effect of soil components.

Microplastics (MPs) have attracted considerable attention due to its worldwide distribution, environmental persistence, and ecological risks. In this work, the photodegradation of MPs mediated by five different types of soils were investigated. The results showed: after 20 d of xenon lamp irradiation, significant degradation of MP was observed on Harbin (S1), Huainan (S2), Jiangxi (S3), Shaanxi (S4) and Hainan (S5).

Core-shell CoFeO@C nanoparticles coupled with rGO for strong wideband microwave absorption.

Strong absorption and large bandwidth are two contributors to materials' absorbing performance. In this work, a series of multi-element core-shell magnetic nano-particle composite layered graphene absorbing materials CoFeO@C/rGO (CCr) were prepared by adjusting carbon shell thickness. The CCr at a low thickness achieved strong microwave absorption and a wide effective absorption bandwidth.

Are Physical Activities Associated With Perceived Stress? The Evidence From the China Health and Nutrition Survey.

Psychological stress is a negative affective state. The association between physical activity and psychological stress was commonly reported in previous researches. Few published studies with large sample sizes have explored such an association in Chinese population.

Mass spectrometry-based metabolomics unravel the transfer of bioactive compounds between rye and neighbouring plants.

Translocation of metabolites between different plant species provides important hints in understanding the fate of bioactive root exudates. In the present study, targeted and untargeted mass spectrometry-based metabolomics was applied to elucidate the transfer of bioactive compounds between rye and several crops and weed species. Our results demonstrated that benzoxazinoids (BXs) synthesized by rye were taken up by roots of neighbouring plant species and translocated into their shoots.

Polysaccharide from Potentilla anserina L ameliorate pulmonary edema induced by hypobaric hypoxia in rats.

High-altitude pulmonary edema (HAPE) is a life-threatening disease occurs in hypobaric hypoxia (HH) environment, which could be treated by Dexamethasone, but might cause side-effects. Potentilla anserina L polysaccharide (PAP) holds promising physiological and pharmacological properties which could be beneficial for HAPE treatment. In our study, the anti-hypoxia effect of PAP was firstly investigated through anti-normobaric hypoxia test and anti-acute hypoxia test.

Preparation and Performance Evaluation of Duotone 3D-Printed Polyetheretherketone as Oral Prosthetic Materials: A Proof-of-Concept Study.

Literature has reported the successful use of 3D printed polyetheretherketone (PEEK) to fabricate human body implants and oral prostheses. However, the current 3D printed PEEK (brown color) cannot mimic the vivid color of oral tissues and thus cannot meet the esthetical need for dental application. Therefore, titanium dioxide (TiO) and ferric oxide (FeO) were incorporated into PEEK to prepare a series of tooth-color and gingival-color PEEK composites in this study.

Genotype-specific Distribution and Change of High-risk Human Papillomavirus Infection and the Association with Cervical Progression Risk in Women with Normal Pathology and Abnormal Cytology in a Population-based Cohort Study in China.

Women with normal pathology screened from abnormal cervical cytology are a special population with higher progression risk than women with normal cytology. However, the associations between genotype distribution and changes of high-risk human papillomavirus (HR-HPV) infection and cervical progression risk in this special population remain unclear. A total of 1232 women with normal pathology screened from abnormal cervical cytology were enrolled into this cohort with 2-year follow-up.

Conformational and rheological properties of bacterial cellulose sulfate.

In this study, a water-soluble bacterial cellulose sulfate (BCS) was prepared with sulfur trioxide pyridine complex (SO3· Py) in a lithium chloride (LiCl)/dimethylacetamide (DMAc) homogeneous solution system using bacterial cellulose (BC). The structural study showed that the value for the degrees of substitution of BCS was 1.23.

Antibacterial polyvinyl alcohol/bacterial cellulose/nano-silver hydrogels that effectively promote wound healing.

The lack of antibacterial properties limits the application of bacterial cellulose hydrogels in wound dressings. To overcome this deficiency, silver nanoparticles (AgNPs) were introduced as antibacterial agents into a polyvinyl alcohol (PVA)/bacterial cellulose (BC) solution. A freeze-thaw method promoted formation of PVA/BC/Ag hydrogels and improved their mechanical properties.

Digital fabrication of a maxillary obturator prosthesis by using a 3-dimensionally-printed polyetheretherketone framework.

The digital fabrication of a maxillary obturator with a 3D-printed polyetheretherketone (PEEK) framework is described. Digital oral data were scanned for the computer-aided design (CAD) of the framework and the 3D printing of a preliminary resin cast. The framework was accurately printed from a PEEK filament material.

A new deep domain adaptation method with joint adversarial training for online detection of bearing early fault.

For online early fault detection of rolling bearings in non-stop scenarios, one of the main concerns is the model bias caused by the distribution shift between offline and online working conditions. Under such concern, how to improve the feature sensitivity to early faults and the robustness of detection model has become a key challenge of improving the effectiveness of online detection. To solve this problem, a new online early fault detection method is proposed in this paper based on a strategy of deep transfer learning.

[Brain tissue microstructure parameters estimation method based on proximal gradient network].

Diffusion tensor imaging technology can provide information on the white matter of the brain, which can be used to explore changes in brain tissue structure, but it lacks the specific description of the microstructure information of brain tissue. The neurite orientation dispersion and density imaging make up for its shortcomings. But in order to accurately estimate the brain microstructure, a large number of diffusion gradients are needed, and the calculation is complex and time-consuming through maximum likelihood fitting.

Near-infrared emitting Cu-In-Se/ZnS core/shell quantum dots: aqueous synthesis and sulfur source effects.

The present study reports an aqueous synthesis approach towards Cu-In-Se/ZnS quantum dots with emission in the near-infrared spectral range. The photoluminescence of the dots can be effectively controlled by adjusting the sulfur source, to achieve increased quantum yields (four times higher) and red-shifted emission peaks (from 809 nm to 830 nm).

Ultra-broadband and covalently linked core-shell CoFeO@PPy nanoparticles with reduced graphene oxide for microwave absorption.

Covalent bond usually ensures a stable connection between nonmetallic atoms. However, the traditional reflux method usually requires the construction of complex instruments and equipment with tedious steps to ensure airtightness and reaction stability. In this work, an advanced method is adopted to bind core-shell CoFeO@PPy and rGO tightly via the aid of 2-(1H-pyrrol-1-yl)ethanamine (PyEA), dispense with a high-temperature environment or protective gas.

Magnetic porous CoNi@C derived from bamboo fiber combined with metal-organic-framework for enhanced electromagnetic wave absorption.

In order to commit to the core concept of energy saving and emission reduction, the preparation of absorbing materials with sustainable development, light weight, strong absorption and wide absorption bandwidth has become an urgent problem that should be solved. As a natural product from nature, ubiquitous bamboo is combined with metal-organic framework on its surface through a simple chemical activation method is demostrated to be an effective method to prepare a composite absorbing material with amazing electromagnetic wave absorption. The prepared bamboo fiber/CoNi alloy (CN-ABF) reaches a minimum reflection loss of -75.