Generation of dynamic oxygen vacancies in graphene quantum dots/NaNbO heterojunction for boosting photocatalytic hydrogen evolution.

The design and theoretical study of green, low-cost heterojunction photocatalysts with strong interfacial interactions are crucial for achieving efficient and stable photocatalytic hydrogen evolution (PHE). This study proposes a simple method to synthesizing graphene quantum dots (GQDs)/NaNbO heterojunction with dynamic oxygen vacancies. GQDs promote the formation of oxygen vacancies and increase the surface-active sites of NaNbO, significantly enhancing light absorption efficiency.

The Ligand Binding Domain of the Cell Wall Protein SraP Modulates Macrophage Apoptosis and Inflammatory Responses in Infections.

The cell wall protein serine rich adhesin for platelets (SraP) belongs to a large surface glycoprotein family of adhesins. Here, we provide experimental evidence that SraP mediates macrophage functions in a human monocyte-derived macrophage model via its N-terminal L-lectin module (LLM) in the ligand binding region. Our flow cytometry data demonstrated that macrophages infected by the LLM deletion strain profoundly impacted apoptosis, reducing the percentage of apoptotic cells by approximately 50%, whereas LLM overexpression significantly increased the percentage of early-stage apoptotic cells ( < 0.

The complete mitochondrial genome of (anura: ranidae).

The complete mitochondrial genome sequence of is 17778 bp in length (GenBank accession number PP734094) and contains 13 protein-coding genes, 2 rRNA genes, and 22 tRNA genes. The mitochondrial gene arrangement of is identical to those of other species and has a typical neobatrachian arrangement. Mitogenomic phylogenetic analysis revealed that is composed of two main clades.

Unleashing the Healing Power: 3D Bioprinting Mimics Hypoxia to Supercharge Mesenchymal Stem Cells.

Mesenchymal stem cells (MSCs) play a critical role in stem cell therapy due to their tissue-mimicking abilities. However, conventional 2D culture conditions often lead to the loss of their native hypoxic niche, potentially limiting their therapeutic efficacy. 3D bioprinting offers a method to recreate intricate biological environments by integrating cells with extracellular matrices.

Effects of irrigation and organic fertilizer on pumpkin yield, quality, and water-fertilizer use efficiency in arid northwest China.

Due to the increasing water scarcity and the need for sustainable agricultural practices in arid regions, optimizing water and fertilizer management is crucial for enhancing crop productivity and resource efficiency. Field experiments in 2022 and 2023 in northwestern China's arid region explored the impacts of irrigation volume, organic fertilizer use, and their coupling on pumpkin yield, quality, and water-fertilizer efficiency. The study included ten treatments with a completely randomized two-factor design, comprising three irrigation quotas, three organic fertilizer application rates and a control group (CK).

State-dependent neural signatures of autistic traits: evidence from fNIRS-based fractional amplitude of low-frequency fluctuation analysis during natural social interaction.

Autistic traits exist on a continuum within the general population, yet how these traits influence regional neural activity during real-world social interactions remains unclear. Using functional near-infrared spectroscopy (fNIRS), we investigated how autistic traits relate to the fractional amplitude of low-frequency fluctuations (fALFF) during both resting-state and real-time conversations in 62 high autistic trait and 58 low autistic trait neurotypical adults. While resting-state differences were minimal, significant group differences emerged during conversation.

GLA deficiency causes cardiac hypertrophy via enhanced autophagy.

Fabry disease is a monogenic disease characterized by a deficiency or loss of α-galactosidase A (GLA). Cardiomyopathy is the leading cause of death in Fabry patients; however, a lack of understanding of the pathological mechanism impedes the development of effective therapies. Here, we used a Gla knockout (KO) mouse model and investigated its impact on cardiomyopathy.

Assessing the effectiveness of continuous glucose monitoring compared with conventional monitoring in enhancing surgical outcomes for patients with diabetes: protocol for a multicentre, parallel-arm, randomised, pragmatic trial in China.

Introduction: The Comprehensive Complication Index (CCI) is an internationally recognised indicator of postoperative complications. During the perioperative period, patients with diabetes mellitus (DM) or impaired glucose tolerance (IGT) may experience a significant increase in the CCI associated with glucose-related complications and increased mortality. Continuous glucose monitoring (CGM) offers advantages such as portability, accuracy, real-time monitoring and rich information.

Electrostatically Enhanced Biomimetic Asymmetric Hydrogel with a Dung Beetle-Inspired Pattern for Internal Trauma Sealing.

Herein, a biologically asymmetric adhesion-patterned hydrogel induced by the dung beetle surface was proposed for internal trauma sealing. The electrostatic interaction-enhanced dual networks endowed the hydrogel patch with superior mechanical performance, thus achieving a favorable sealing ability. Poly(acrylic acid) (AA), chitooligosaccharide (COS), and gelatin were used as the composition of our hydrogel system.

Lipid-lowering drug clofibric acid promotes conjugative transfer of RP4 plasmid carrying antibiotic resistance genes by multiple mechanisms.

Antibiotic resistance represents a growing global health crisis, predominantly driven by the selective pressure imposed by antibiotics, which facilitates horizontal gene transfer. However, the potential role of non-antibiotic pharmaceuticals in promoting or enabling the spread of antibiotic resistance genes (ARGs) remains poorly understood. This study provided novel insights into the capacity of clofibric acid, a lipid-lowering drug, to enhance the conjugative transfer of ARGs, and deeply explored the underlying multiple mechanisms.

Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis.

Background: Drug therapy plays an essential role in the management of hepatocellular carcinoma (HCC). Recently, the use of natural products to suppress tumor cells has emerged as a promising direction for drug development. Juglone, a natural compound, exhibits anticancer activities across various cancer types.

Characterization and antioxidant activity of differentiated fractionation lignin from corn stover.

Lignin contains many chemical functional groups with multiple biological activities. However, the heterogeneity of lignin such as complex structure and high polydispersity, and poor dissolution performance hinders its value-added application. In this study, it was found that there was a significant difference in the solubility of the chemical components of corn stover alkali-extracted lignin-carbohydrate complex (CSALCC) in a 0.

Anchoring Ag(I) into MOF-253 for Effectively Catalyzing Cycloaddition of CO with Alkynyl Alcohols/Amine under Ambient Conditions.

In the era of global warming, the conversion of carbon dioxide into high-value products has become a widely scrutinized emerging mitigation strategy. Metalation of bpy-containing MOF-253 led to the synthesis of MOF-253-0.5Ag, which acts as an efficient catalyst for the carbonylative cyclization of CO with alkyne molecules (such as propynyl alcohols and propynyl amines) at room temperature and ambient CO pressure, yielding the corresponding α-alkyl cyclic carbonates and oxazolidinones, thus endowing the catalytic system with bifunctional characteristics.

Two-Level Spatially Localized Proximity Labeling for Cross-Biological-Hierarchy Measurement and Manipulation.

Proximity labeling (PL) has emerged as a powerful technique for the in situ elucidation of biomolecular interaction networks. However, PL methods generally rely on single-biological-hierarchy control of spatial localization at the labeling site, which limits their application in multi-tiered biological systems. Here, we introduced another enzymatic reaction upstream of an enzyme-based PL reaction and targeted the two enzymes to markers indicating different biological hierarchies, establishing a two-level spatially localized proximity labeling (PL) platform for in situ molecular measurement and manipulation.

Tropical Indian Ocean drives Hadley circulation change in a warming climate.

The weakening and poleward expansion of the Hadley circulation (HC) are considered robust responses of atmospheric meridional circulation to anthropogenic warming. Climate impacts arising from these changes enhance drought conditions and reduce food production in the affected regions. Therefore, understanding the mechanisms of HC changes is critical to anticipating the resultant climate risks.

Efficacy and safety of wet cupping in the treatment of neurodermatitis: a systematic review and meta-analysis.

Background: Neurodermatitis is a chronic skin condition characterized by intense itching and skin thickening due to neurological dysfunction. Its persistent nature poses a challenge to effective treatment, significantly impacting patients' quality of life. Wet cupping therapy is increasingly being used in clinics to manage neurodermatitis, so it is imperative to assess the evidence regarding its effectiveness and safety.

Research hotspots and trends of neuroimaging in social anxiety: a CiteSpace bibliometric analysis based on Web of Science and Scopus database.

Background: This study focused on the research hotspots and development trends of the neuroimaging of social anxiety (SA) in the past 25 years.

Methods: We selected 1,305 studies on SA neuroimaging from the Web of Science and Scopus from January 1998 to December 2023. CiteSpace was used to analyze the number of published articles visually, cited references, cooperation among authors and institutions, co-occurrence of keywords, clustering of keywords, burst of keywords, and time zone of co-occurring keywords.

Serum Galectin-9 mirrors immune-evasive microenvironment and predicts early recurrence in hepatocellular carcinoma.

Background: The precise role of Galectin-9, an immune checkpoint protein involved in immune responses, in hepatocellular carcinoma (HCC) remains elusive. Importantly, the prognostic value of serum Galectin-9 has not been clarified, and its association with infiltrating immune characteristics was unclear.

Methods: The association between serum Galectin-9 concentration and HCC recurrence was analyzed in two cohorts of HCC patients (training 133; validation 97) who received curative resection during 2018 and 2019.

Macrophage MST1 protects against schistosomiasis-induced liver fibrosis by promoting the PPARγ-CD36 pathway and suppressing NF-κB signaling.

Schistosomiasis is characterized by egg-induced hepatic granulomas and subsequent fibrosis. Monocyte-derived macrophages play critical and plastic roles in the progression and regression of liver fibrosis, adopting different polarization phenotypes. Mammalian STE20-like protein kinase 1 (MST1), a serine/threonine kinase, has been established to act as a negative regulator of macrophage-associated inflammation.

Higher Intraocular Levels of Inflammatory Factors are Related to Retinal Vascular and Neurodegeneration in Myopic Retinopathy.

Purpose: In this study, we aimed to investigate the relationship between the intraocular levels of inflammatory factors and myopia-related retinal vascular and neuronal degeneration.

Patients And Methods: One hundred and forty-seven patients with Implantable Collamer Lens (ICL) implantation were enrolled and all participants received comprehensive ophthalmic examination. About 100~150 ul of aqueous humor was collected immediately before ICL surgery.

Stressor-Actuated Proximity Labeling for Reporting Cellular Interaction.

Cell-cell interactions determine the activation state and function of cells. When host cells are exposed to stressors such as microorganisms, immune defense machinery is activated to release HO, providing direct evidence of the relevant cellular physiological processes. Inspired by the fact that peroxidase can catalyze proximity labeling in the presence of exogenous HO, a stressor-actuated proximity labeling (SAPL) strategy is developed to report the process information on cell-cell interactions by recording stress levels.

Organic fertilizer increases pumpkin production by improving soil fertility.

Compared with long-term and continuous application of large amounts of chemical fertilizers, fertilizers with microbial organic nutrient sources can improve soil environment, increase soil fertility and increase crop yield. In view of the current low soil fertility and poor soil environment leading to low crop yield and instability in the arid regions of northwest China, the effects of organic fertilizer with microbial nutrient sources on soil nutrients and pumpkin yield were studied in 2022 and 2023 in this region. The fertilizer application level was used as control factor, with four treatments of low level (L), medium level (M), high level (H), and a conventional fertilizer control (CK).