Publications by authors named "Ding Lei"

This study aims to optimize the process for preparing chitosan-based ultrasound-coupled hydrogel pads and investigate their application potential in ultrasonography. Chitosan, 2-acrylamido-2-methylpropanesulfonic acid, and N-isopropylacrylamide were used as the main materials to prepare chitosan-based ultrasound-coupled hydrogel pads. The free-radical polymerization conditions were optimized by a three-factor, three-level orthogonal test with the tensile strength and ultrasound image quality of the hydrogel pads as evaluation indicators.

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The plasma membrane aquaporin ZmPIP1;6 is expressed in maize stomatal complexes, with higher expression during the day than at night. To elucidate the role of ZmPIP1;6 in gas exchange and stomatal movement, it was expressed in maize (inbred line B104) under the control of p35S promoter (OE) or its native promoter fused with mYFP cDNA (mYFP-ZmPIP1;6). In stomatal complexes of the leaf mature zone, mYFP-ZmPIP1;6 showed higher expression in subsidiary cells than in guard cells, with light and dark treatments influencing its subcellular localization.

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Attention impairment, a prevalent non-motor symptom in Parkinson's disease (PD), plays a crucial role in movement disorders. PD patients exhibit abnormalities in the attentional network related to alerting, orienting, and executive control. While dopamine medications have well-documented effects on motor function, their impact on attention networks and the underlying neural mechanisms involved in motor functions remain unclear.

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Job advertisements (ads) represent the first point of contact between employers and job seekers. By signaling characteristics expected of an ideal candidate, job ads "gatekeep" the labor force and configure its composition. Meanwhile, labor force composition can also shape the wording of job ads.

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Background: To evaluate the efficacy and safety of the first cohort of people in China treated with a responsive neurostimulation system (EpilcureTM, GenLight MedTech, Hangzhou, China) for focal drug-resistant epilepsy in this study.

Methods: This multicenter, before-and-after self-controlled study was conducted across 8 centers from March 2022 to June 2023, involving patients with drug-resistant epilepsy who were undergoing responsive neurostimulation (RNS). The study was based on an ongoing multi-center, single-blind, randomized controlled study.

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Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in critically ill patients and significantly impacts mortality. This study sought to evaluate the impact of new-onset AF on mortality in a critically ill population.

Methods: This study identified 48018 adult patients admitted to the ICU from the Medical Information Mart for Intensive Care (MIMIC)-IV database.

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  • The study addresses the high energy consumption of welding workshops and aims to reduce carbon emissions during the production process by developing a bi-objective scheduling model that minimizes both completion time and carbon output.
  • An improved Grey Wolf Optimizer (IGWO) is introduced to tackle the multi-objective scheduling problem, incorporating strategies to enhance diversity, convergence, and local optimization.
  • The results demonstrated that the IGWO algorithm significantly lowered carbon emissions to 3.85E + 05 while reducing the completion time to 842.14, outperforming other algorithms like NSGA-II and GWO.
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This article is concerned with fully distributed Nash equilibrium seeking in networked games under both undirected and directed communication graphs. New fully Nash equilibrium seeking strategies incorporating gradient-based optimization algorithms, consensus algorithms, and double-layer adaptive control laws are presented. In particular, the double-layer adaptive control laws are introduced to ensure that the control gains are not overlarge and free of dependence on any global information.

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  • Despite advances in treating hepatocellular carcinoma (HCC), patients with advanced stages still face poor outcomes, highlighting the urgent need for better therapies.
  • Lenvatinib (Len) shows promise as a targeted treatment for HCC, but challenges like low stability, poor absorption, and toxic side effects limit its effectiveness for immune modulation.
  • The study introduces ultrasound-triggered lenvatinib nanoparticles (Len-RNPs) that improve drug delivery, reduce toxicity, and significantly boost anti-tumor immune responses, achieving a 95.7% tumor suppression rate in a mouse model.
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The interface modification between perovskite and electron transport layer (ETL) plays a crucial role in achieving high performance inverted perovskite photovoltaics (i-PPVs). Herein, non-fullerene acceptors (NFAs), known as Y6-BO and Y7-BO, were utilized to modify the perovskite/ETL interface in i-PPVs. Non-polar solvent-soluble NFAs can effectively passivate surface defects without structural damage of the underlying perovskite films.

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Aims: Diabetic kidney disease (DKD) develops in approximately 40% of patients with type 2 diabetes mellitus (T2DM). The role of folate metabolites in the progression from T2DM to DKD has not been clearly articulated. Our aim was to assess the association of folate metabolites with DKD.

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The growing elderly population presents a significant concern, with the prolongation of life expectancy, aging diseases are becoming increasingly common. Resveratrol (RSV) has emerged as a promising compound for disease prevention. However, the effect of RSV on lifespan extension in different organisms, particularly the model organism silkworm, remains inconsistent.

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Background: Catheter ablation has evolved as a safe treatment for atrial flutter (AFL) in patients with pulmonary hypertension (PH), and the recurrence of AFL may accelerate clinical decompensation. The aim of this study was to determine the recurrence rate and risk factors for recurrent AFL in PH patients after ablation.

Methods: All PH patients who underwent AFL ablation at Fuwai Hospital between May 2015 and December 2020 were followed up.

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Tumor cells can survive when detached from the extracellular matrix or lose cell-to-cell connections, leading to a phenomenon known as anoikis resistance (AR). AR is closely associated with the metastasis and proliferation of tumor cells, enabling them to disseminate, migrate, and invade after detachment. Here, we have investigated a novel composite nanoenzyme comprising mesoporous silica/nano-cerium oxide (MSN-Ce@SP/PEG).

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Regulating the coupled relationship among water, nitrogen, and biochar is an effective strategy for increasing production and reducing emissions in greenhouse agriculture. However, a comprehensive evaluation model remains lacking. Toward this end, we aimed to evaluate the emission patterns of greenhouse gases and greenhouse tomato yield during the spring and autumn cultivation seasons as influenced by irrigation water use efficiency, nitrogen fertilizer partial productivity, and soil organic carbon (SOC).

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Article Synopsis
  • Mechanical forces play a crucial role in regulating cellular activities, and understanding these forces is key to discovering fundamental biological mechanisms.
  • Researchers developed a new microprobe that can measure biological forces in living cells at the nanonewton level, enhancing experimental precision significantly.
  • Using this advanced probe, they measured the elasticity modulus of HeLa cells at 1.27 ± 0.3 kPa, paving the way for more detailed studies of 3D cellular mechanics.
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Study Design: Cross-sectional study.

Objectives: This study's goal is to report whether Magnetization Transfer Ratio (MTR) can evaluate the severity of white matter (WM) injury in degenerative cervical myelopathy (DCM).

Setting: Laureate Institute of Brain Research, USA; Department of Neurosurgery, University of Oklahoma Health Sciences Center, USA.

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Background: CXC chemokine CXCL12 is involved in the pathological development of rheumatoid arthritis (RA) through abnormal migration of peripheral immune cells in the joint. Although low dose methotrexate (MTX) is clinically used to treat RA patients, CXCL12 signaling responses to MTX-mediated treatments is still not well understood.

Methods: In this study, we examined the expression of CXCR4 (cognatic receptor for CXCL12) in peripheral T cells from RA patients and arthritis mice models received from low dose MTX therapies.

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Polyolefin separators with worse porous structures and compatibilities mismatch the internal environment and deteriorate lithium-ion battery (LIB) combination properties. In this study, a sulfonated SiO (SSD) composited polypropylene separator (PP@SSD) is prepared to homogenize pore sizes and in situ-built SSD coatings on porous skeletons. Imported SSD uniformizes pore sizes owing to centralized interface distributions within casting films.

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  • A new photocatalytic platform was created to efficiently convert solar energy and seawater into hydrogen, overcoming previous limitations in catalyst activity and scalability.
  • This platform features a unique design with a molecular heterojunction and micro-nanoscale pore structures, improving charge transfer and photocatalytic activity compared to traditional systems.
  • Under testing, the platform achieved impressive hydrogen production rates that surpass many inorganic systems, indicating a promising step towards sustainable hydrogen production from seawater using solar power.
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Breast cancer (BC) has become the most life-threatening cancer to women worldwide, with multiple subtypes, poor prognosis, and rising mortality. The molecular heterogeneity of BC limits the efficacy and represents challenges for existing therapies, mainly due to the unpredictable clinical response, the reason for which probably lies in the interactions and alterations of diverse cell death pathways. However, most studies and drugs have focused on a single type of cell death, while the therapeutic opportunities related to other cell death pathways are often neglected.

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  • * This actuator integrates photonic crystals and a hygroscopic layer to create a system that can self-flicker and change colors in response to humidity, using automated cyclic motion.
  • * The actuator can be used in applications like self-flapping biomimetic butterflies and dynamic visual displays, showcasing its potential in intelligent robotics and optical technologies.
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Background: Due to frequent and high-risk sports activities, the elbow joint is susceptible to injury, especially to cartilage tissue, which can cause pain, limited movement and even loss of joint function.

Aim: To evaluate magnetic resonance imaging (MRI) multisequence imaging for improving the diagnostic accuracy of adult elbow cartilage injury.

Methods: A total of 60 patients diagnosed with elbow cartilage injury in our hospital from January 2020 to December 2021 were enrolled in this retrospective study.

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