Publications by authors named "Ding Juan-Juan"
Article Synopsis
- * Key findings include the presence of lamellated glomerular basement membranes in 65.5% of children, with a significant number (73.1%) testing negative for collagen-a5, indicating important clinical implications.
- * The research also noted that boys exhibited more typical pathology than girls, and those with severe mutations were more prone to kidney-related symptoms and hearing loss, underscoring the value of combining renal pathology with next-generation sequencing for diagnosis.
[Reversible posterior leukoencephalopathy syndrome secondary to acute nephritis in a child].
Zhongguo Dang Dai Er Ke Za Zhi
November 2014
Objective: To explore the therapeutic efficacies of inhaled corticosteroids (ICS) plus low-dose theophylline for moderate bronchial asthma.
Methods: A total of 280 patients with moderate bronchial asthma at People's Hospital of Zhengzhou University between January 2011 and December 2011 were recruited and randomized into 2 groups: observation group with inhaled budesonide 400 µg/d plus aminophylline tablet (0.1 g, 3 times/day, oral administration and control group with inhaled budesonide 320 µg/day plus formoterol 9 µg/day.
[Preliminary analysis of urinary proteomics in children with steroid-resistant and steroid-sensitive nephrotic syndrome].
Zhongguo Dang Dai Er Ke Za Zhi
May 2009
Objective: To study and identify the protein markers in the urine of children with steroid-sensitive (SSNS) and steroid-resistant nephrotic syndrome(SRNS).
Methods: Total urinary proteins were extracted from children with SSNS before and after steroid therapy, SRNS, and healthy children (n=5 in each group). Urinary proteins were separated by immobilized pH gradient based on two-dimensional gel electrophoresis (2-DE).
[Clinical characteristics of Cronkhite-Canada syndrome in Chinese: meta-analysis of 35 cases].
Zhonghua Yi Xue Za Zhi
November 2007
Objective: To investigate the clinical characteristics of Chinese patients with Cronkhite-Canada syndrome (CCS).
Methods: Relevant data of Chinese CCS patients from 1985 to 2006 were retrieved from Medline and Chinese biomedical database and a meta-analysis was conducted.
Results: A total of 35 CCS cases had been reported by Chinese hospitals with the clinical characteristics of gastrointestinal polyposis with ectodermal trilogy, mainly manifested as diarrhea, bellyache, weight loss, anemia, and edema.
Effect of glucocorticoid receptor beta on glucocorticoid action in glomerular mesangial cells.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
December 2007
Objective: To construct mesangial cell lines over- or under- expressing glucocorticoid receptor beta (GRbeta), to investigate the effect of GRbeta on glucocorticoid biological function, and to determine whether the overexpression of GRbeta explains the glucocorticoid-resistant in glomerular mesangial cells (GMCs).
Methods: The recombinant human sense or anti-sense gene of GRbeta was transferred into the rat GMCs by retrovirus-mediated stable transfection technique. Expression of hGRbeta mRNA in GMCs was determined by reverse transcription of total RNA followed by quantitative reverse transcription-polymerase chain reaction (RT-PCR), and the product of RT-PCR was then analyzed by gene sequencing.
Objective: To establish a urinary proteomic map on two-dimensional polyacrylamide gelelectrophoresis (2-DE) in children with idiopathic nephrotic syndrome (INS).
Methods: The proteins from INS children were purified by four various means, separated by 2-DEand stained by silver.
Results: The sequential preparation of urinary proteins by acetone precipitation and dislysis, when the sample was 300 microg, resulted in a clear background, well-resolved and reproducible 2-DE urinary protemic map in children with INS.