Methods for the Synthesis of Endohedral Fullerenes.

In the present manuscript the authors show the progress recorded regarding the main synthesis methods of metal endo-fullerenes. Shown, that nowadays, the most productive and common method of producing endohedral fullerenes is the electric arc process due to the fact that (a) it is simple enough to introduce atoms into the plasma from solids and gases; (b) its performance is the highest among other methods; (c) gives a wide range of produced types of metallofullerenes in an inert atmosphere-mono-, di-, tri-metalfullerenes, metal carbide clusters, in a reactive atmosphere (N₂, NH₃)-metal nitride and cyanide clusters, heterofullerenes; (d) provides the greatest energy potential, which is likely to allow the introduction into the cells of fullerene molecules metal atoms with higher ionization energies than titanium (≥7 eV). The yield of metal endofullerenes is substantially higher than the "empty" fullerenes.

Gadolinium Endofullerenes.

Fullerenes-A new combining atoms of carbon atoms into the molecule, which can serve as the parent and precursor of a whole class advanced organic compounds. Unsolved problems associated with a correct understanding of the structure, transformation, and behavior of the fullerene C molecule, make it impossible to interpret correctly many of its physicochemical properties. Fullerenes are a new compounds of carbon atoms into a molecule that can serve as the parent and precursor of the whole class of the newest organic compounds.

Post-mastectomy immediate breast reconstruction is oncologically safe in well-selected T4 locally advanced breast cancer: a large population-based study and matched case-control analysis.

Purpose: Although it is well accepted that the survival outcome is most probably unaffected by immediate breast reconstruction (IBR) for T1-T3 tumors, the safety of IBR in T4 locally advanced breast cancer (LABC) remains unclear.

Methods: By using data from the Surveillance, Epidemiology, and End Results (SEER) database, the trend of IBR for female T4 LABC patients undergoing mastectomy, chemotherapy and radiotherapy was explored. The predictors of IBR in T4 LABC were evaluated by multivariate logistic regression.

The Prognostic Significance of the Oncotype DX Recurrence Score in TNM Estrogen Receptor-Positive HER2-Negative Breast Cancer Based on the Prognostic Stage in the Updated AJCC 8th Edition.

Background: This study aimed to evaluate the prognostic significance of the Oncotype DX recurrence score (RS) in TNM estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer based on the prognostic stage in the updated American Joint Commission on Cancer, 8th edition.

Methods: The Surveillance, Epidemiology, and End Results database was searched to identify ER-positive invasive ductal breast cancer in TNM with RS results diagnosed between 2004 and 2012. Patients with RS were categorized into low-risk (RS < 11), intermediate-risk (RS 11-25), and high-risk (RS > 25) groups.

Evaluation of the prognostic stage in the 8th edition of the American Joint Committee on Cancer in locally advanced breast cancer: An analysis based on SEER 18 database.

Background: The new "prognostic stage" in the 8th edition of the American Joint Committee on Cancer (AJCC) incorporated important biologic factors such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2), histologic grade and TNM stage into one system. The objective of this study was to evaluate the "prognostic stage" in locally advanced breast cancer (LABC) based on the Surveillance, Epidemiology, and End Results (SEER) 18 database.

Methods: 10053 LABCs diagnosed between 2010 and 2013 were enrolled.

Impact of central obesity on prognostic outcome of triple negative breast cancer in Chinese women.

Purpose: To evaluate the prognostic effect of central obesity on triple negative breast cancer (TNBC).

Methods: 206 TNBC patients treated from June 2006 to June 2015 were enrolled retrospectively. Body mass index (BMI) ≥25 kg/m(2) was the standard of obesity and waist circumference ≥80 cm was the standard of central obesity.

Comparison of invasive micropapillary and triple negative invasive ductal carcinoma of the breast.

Background: Invasive micropapillary carcinoma (IMPC) of the breast and triple negative breast cancer (TNBC) are both aggressive subtypes, but little information is available on their comparison.

Patients And Methods: Retrospective analysis of 95 IMPC and 200 TNBC-IDC (invasive ductal carcinoma) was conducted to compare the clinicopathologic characteristics and survivals.

Results: For IMPC, pN was the independent prognostic factor of local-regional recurrence free survival (LRRFS) (P = 0.

Prognostic effect analysis of molecular subtype on young breast cancer patients.

Objective: To make a prognostic effect analysis of molecular subtype on young breast cancer patients.

Methods: Totally 187 cases of young breast cancer patients less than 40 years old treated in Obstetrics and Gynecology Hospital of Fudan University between June 2005 and June 2011 were included in our study. We described their clinical-pathological characteristics, disease-free survival (DFS) rate, and overall survival (OS) rate after a median follow-up period of 61 months.

Structure and conformational dynamics of a stacked dimeric G-quadruplex formed by the human CEB1 minisatellite.

CEB1 is a highly polymorphic human minisatellite. In yeast, the size variation of CEB1 tandem arrays has been associated with the capacity of the motif to form G-quadruplexes. Here we report on the NMR solution structure of a G-quadruplex formed by the CEB1 DNA G-rich fragment d(AGGGGGGAGGGAGGGTGG), harboring several G-tracts including one with six continuous guanines.