Publications by authors named "Dineshsinha Chauhan"
Cancers (Basel)
September 2024
Article Synopsis
- DNA-dependent protein kinase (DNA-PK) plays a crucial role in repairing DNA double-strand breaks and is a target for cancer therapies to enhance the effectiveness of radiation treatments.
- Researchers have developed new oxindole Ku-DNA binding inhibitors (Ku-DBis) that show better cellular uptake and strong inhibition of Ku proteins, demonstrating variable effectiveness across different non-small cell lung cancer (NSCLC) cell lines.
- In vivo studies reveal that Ku-DBis can block DNA-PK autophosphorylation, alter DNA damage responses, and lower tumor cell growth, indicating their potential use in improving cancer treatment outcomes.
