Voyage of theranostic liposomes for imaging and therapy.

Drug delivery is a critical issue in any disease treatment. Nowadays much more effort is being focused on integrating imaging agent and therapeutic drugs in a single formulation to achieve a simultaneous disease diagnosis and targeted drug delivery. This new terminology 'nanotheranostics' have been used to describe these nanoparticle formulations.

Design of sustained release pellets of ferrous fumarate using cow ghee as hot-melt coating agent.

Introduction: The objective of the present study was to design ferrous fumarate (FF) sustained release (SR) pellets using of cow ghee (CG) as an important hot-melt coating (HMC) agent.

Materials And Methods: The pellets were coated by HMC technique using CG and ethyl cellulose composition by conventional coating pan without the use of spray system. FF formulated as pellets and characterized with regard to the drug content and physico-chemical properties.

An improvement in physicochemical properties of carvedilol through spherically agglomerated solid dispersions with PVP K30.

Spherically agglomerated solid dispersions of carvedilol (CAR) were prepared with polyvinyl-pyrrolidone (PVP) using acetone, water and dichloromethane as solvent, non-solvent and bridging liquid, respectively. The prepared agglomerates were evaluated for its percentage yield, drug content, morphology, thermal behavior, micromeritic properties, aqueous solubility and in vitro drug release. Differential scanning calorimetric and powder X-ray diffraction studies confirm that formulation process altered the crystalline nature of carvedilol.

Effects of Murraya koenigii leaf extract on impaired gastrointestinal motility in streptozotocin-induced diabetic rats.

Objective: The present study was to investigate the effects of Murraya koenigii leaf (MKL), an Indian herb, on glucose homeostasis, intestinal transit time, response to exogenous acetylcholine of smooth muscles of distal colon, and intestinal thiobarbituric acid reactive substance (TBARS) level in streptozotocin (STZ)-induced diabetic rats.

Methods: Male adult Wistar rats were used in this study. Diabetes was induced in the rats by STZ (70 mg/kg, intravenously).