Publications by authors named "Dinesh Nagi"

Aims: To investigate characteristics of people hospitalized with coronavirus-disease-2019 (COVID-19) and diabetic ketoacidosis (DKA) or hyperosmolar hyperglycaemic state (HHS), and to identify risk factors for mortality and intensive care admission.

Materials And Methods: Retrospective cohort study with anonymized data from the Association of British Clinical Diabetologists nationwide audit of hospital admissions with COVID-19 and diabetes, from start of pandemic to November 2021. The primary outcome was inpatient mortality.

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Objective: To determine the association between prescription of SGLT2 inhibitors (SGLT2is) and diabetic ketoacidosis (DKA) incidence or mortality in people with type 2 diabetes (T2D) hospitalized with COVID-19.

Research Design And Methods: This was a retrospective cohort study based on secondary analysis of data from a large nationwide audit from a network of 40 centers in the U.K.

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Article Synopsis
  • The study aimed to evaluate how the use of RAASi and statins before hospital admission affects mortality rates in adults with diabetes after being hospitalized for COVID-19.
  • Data were collected from 99 hospitals across the UK, France, and Spain during the pandemic's first wave, analyzing 3474 individuals for mortality correlations with different medication combinations.
  • The results showed no significant link between the use of RAASi or statins (individually or together) and mortality rates, suggesting that prescribing practices for these medications should remain unchanged for diabetic patients during COVID-19.
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Summary: Primary hyperparathyroidism (PHPT) is a disease caused by overactive parathyroid glands with consequent hypercalcaemia. The main cause in 85-90% of the cases is the presence of a solitary parathyroid adenoma. The most common presentation is with asymptomatic hypercalcaemia diagnosed on routine biochemical testing.

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Sodium glucose co-transporter 2 (SGLT2) inhibitors are now an established class of medications for the treatment of type 2 diabetes (T2D), no longer reserved for use by specialists in diabetes. They are being used increasingly for their cardiac and renal benefits by primary care, cardiology and renal teams for indications in parallel with diabetes care as part of holistic management. This guidance provides essential information on SGLT therapy, including the main advantages and the important risks of which healthcare professionals should be aware.

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Aims/hypothesis: The aim of this work was to describe the clinical characteristics of adults with type 1 diabetes admitted to hospital and the risk factors associated with severe coronavirus disease-2019 (COVID-19) in the UK.

Methods: A retrospective cohort study was performed using data collected through a nationwide audit of people admitted to hospital with diabetes and COVID-19, conducted by the Association of British Clinical Diabetologists from March to October 2020. Prespecified demographic, clinical, medication and laboratory data were collected from the electronic and paper medical record systems of the participating hospitals by local clinicians.

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Article Synopsis
  • Dapagliflozin and sotagliflozin are SGLT inhibitors recommended for people with type 1 diabetes and a BMI of 27 kg/m² or higher; dapagliflozin is licensed in the UK, while sotagliflozin may become available in the future.
  • These drugs can help improve glycemic control and offer additional benefits such as weight loss, better blood pressure management, and increased time in the optimal glucose range.
  • However, there's a risk of diabetic ketoacidosis, especially in individuals at higher risk due to factors like low-calorie diets, illnesses, or reduced insulin, prompting a need for careful management and guidance from healthcare professionals.
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Background: Individuals with a learning disability (LD) are at higher risk of developing type 2 diabetes, but LD is not straightforward to define or identify, especially at the milder end of the spectrum, which makes case finding difficult. While supported self-management of health problems is now established, current material is largely educational and didactic with little that facilitates behavioural change. The interaction between the person with diabetes and others supporting their care is also largely unknown.

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Purpose: To provide estimates of visual impairment in people with diabetes attending screening in a multi-ethnic population in England (United Kingdom).

Methods: The Diabetic Retinopathy In Various Ethnic groups in UK (DRIVE UK) Study is a cross-sectional study on the ethnic variations of the prevalence of DR and visual impairment in two multi-racial cohorts in the UK. People on the diabetes register in West Yorkshire and South East London who were screened, treated or monitored between April 2008 to July 2009 (London) or August 2009 (West Yorkshire) were included in the study.

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Aims: To compare the prevalence of diabetic retinopathy (DR) in people of various ethnic groups with diabetes in the United Kingdom (UK).

Methods: The Diabetic Retinopathy In Various Ethnic groups in UK (DRIVE UK) Study is a cross-sectional study on the ethnic variations of the prevalence of DR and visual impairment in two multi-racial cohorts in the UK. People on the diabetes register in West Yorkshire and South East London who were screened, treated or monitored between April 2008 to July 2009 (London) or August 2009 (West Yorkshire) were included in the study.

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The purpose of this study was to evaluate the effects of an 8-week, low frequency, hospital-based resistance training programme on metabolic risk factors in type 2 diabetic patients. Participants were self-selected into either an 8-week resistance training programme or a control group. Anthropometric indices, fasting glucose, HbA1c, total cholesterol, HDL and LDL lipoproteins, triglycerides, fasting insulin, and insulin sensitivity were assessed at baseline and 8 weeks later.

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Aim: To assess the provision of UK paediatric and adolescent diabetes services and examine changes in service delivery since 2002.

Method: Questionnaires were sent to the lead paediatric consultant from all paediatric and adolescent diabetes services (n=205). Questions were based on National Institute for Health and Clinical Excellence and Scottish Intercollegiate Guidelines recommendations for diabetes care in childhood.

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Aims: The National Diabetic Retinopathy Screening Committee has recommended 19 standards for quality assurance of screening programmes in the United Kingdom. Five of the standards apply to the care provided by ophthalmology departments. This study assesses the quality assurance of the eye care provided by the Wakefield and North Kirklees Screening programme.

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An online survey of consultant diabetologists in the UK examined the interface between specialist services and acute-general internal medicine (acute-GIM). Out of 592 consultants, 289 (49%) responded. Of these, 94% contributed to acute-GIM, devoting equivalent time to acute-GIM and specialist diabetes services.

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