Nanocatalysts: applications for the synthesis of N-containing five-membered heterocycles.

Using transition metals as nanocatalysts has opened up a vast new area in heterocyclic chemistry in the modern day. Heterocyclic moieties are significant scaffolds that have both pharmacological and industrial applications. Various scientific groups have focused their attention on the expansion of simple reaction protocols by introducing better functional group compatibilities under mild reaction conditions through the use of easily available starting materials.

Antimicrobial studies, synthesis and characterization of novel 1-nitro-10H-phenothiazine bearing sulfone/nucleoside moieties.

The current research article involves one pot synthesis of novel substituted 1-nitro-10H-phenothiazines via Smiles rearrangement. These substituted phenothiazines undergo oxidation to yield 10H-phenothiazine-5,5-dioxides (sulfones) while on treatment with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate yield ribofuranosides. These compounds were screened for their antimicrobial vitalities (in vitro) against selected strains of bacteria and fungi.