Safe and Personalized Meal Bolus Calculator for Type-1 Diabetes Using Bayesian Optimization.

Despite several developments in artificial pancreas technology, postprandial glycemic regulation remains to be a major challenge for type 1 diabetes management. Typically, the large spike in blood glucose concentration induced by meals require an appropriate dose of bolus insulin. Although matching bolus insulin to carbohydrate intake has been shown to improve glycemic regulation, current state-of-the-art meal bolus calculators depend on patient-specific parameters and/or historical clinical data, which may not be easily available.

The diagnostic utility of D-dimer and other clinical variables in pregnant and post-partum patients with suspected acute pulmonary embolism.

Background: Pulmonary embolism (PE) during pregnancy remains one of the leading causes of maternal morbidity and mortality in the developed world. However, there is a paucity of high-quality evidence resulting in a lack of consensus in managing this group of patients. The aims of the study were to address the diagnostic utility of D-dimer for suspected PE in pregnant and post-partum patients and to identify any clinical presentation variables that are predictors of PE in this group of patients.