Influence of dietary antioxidants and fatty acids on neutrophil mediated bacterial killing and gene expression in healthy Beagles.

Dietary (n-3) fatty acids from fish oil have been used to modulate immune function in many mammalian species. Together, dietary antioxidants and behavioral enrichment have been shown to enhance neutrophil phagocytosis in geriatric Beagle dogs. The purpose of this study was to further investigate the effects of vitamins E and C, in combination with dietary fish oil, on neutrophil mediated bacterial killing, and on transcript levels of selected neutrophil mRNA.

Pharmacokinetics of orally administered DL-α-lipoic acid in dogs.

Objective: To determine the pharmacokinetics of DL-α-lipoic acid in dogs when administered at 3 dosages via 3 methods of delivery.

Animals: 27 clinically normal Beagles.

Procedures: In a 3 × 3 factorial Latin square design, 3 dosages (2.

In vivo measurement of flatulence and nutrient digestibility in dogs fed poultry by-product meal, conventional soybean meal, and low-oligosaccharide low-phytate soybean meal.

Objective: To determine an optimal window for determining peak flatulence and evaluate the effects of oligosaccharides and supplemental beta-mannanase in soybean meal-based diets on nutrient availability and flatulence.

Animals: 6 dogs.

Procedures: Dogs were used in a 2 x 3 factorial arrangement of treatments in a 6 x 6 Latin square experiment to evaluate the digestibility, flatulence, and fecal odor metabolites of low-oligosaccharide low-phytate soybean meal (LLM), conventional soybean meal (SBM), and poultry by-product (PBP) meal diets with or without supplemental beta-mannanase (5 g/kg).

Effects of serum vitamin E levels on skin vitamin E levels in dogs and cats.

Skin problems are common in small animal practice. Oxidative stress, or the imbalance between prooxidants and the body's antioxidant defense system, likely plays a role in the development of skin disease. According to this study, increasing amounts of vitamin E in foods for dogs and cats increases serum and cutaneous concentrations of vitamin E.

Safety of long-term feeding of dl-alpha-lipoic acid and its effect on reduced glutathione:oxidized glutathione ratios in beagles.

Alpha-lipoic acid is touted as a powerful antioxidant and possibly a conditionally essential nutrient in older mammals. The safety and efficacy of dl-alpha-lipoic acid was evaluated in 30 adult beagles that were evenly randomized into five groups, each of which was fed one of five different foods with varying inclusion rates of dl-alpha-lipoic acid (0, 150, 1500, 3000, and 4500 ppm). All dogs were fed their respective portion of food daily as their sole source of nutrition for 6 months.

Degradation of chlorophenoxyacetic acids by the lignin-degrading fungus .

We have examined the degradation of C ring- and side-chain-labelled 2,4,5-trichlorophenoxyacetic acid by and The effects of Mn on the degradation of these radiolabeled substrates by D. squalens and the effect of nitrogen limitation on their degradation by suggested that in both fungi, side-chain cleavage was catalysed by a mechanism independent of the lignin degradation system, whereas the degradation of the aromatic ring was dependent on the lignin degradative system. Using unlabelled substrates, a pathway for the degradation of chlorophenoxyacetic acids was elucidated in Time courses for the degradation of unlabelled chlorophenoxyacetic acids by demonstrated that the corresponding chlorophenol was the initial product formed.