Publications by authors named "Dinesh D Borhade"
Ann Pharm Fr
September 2024
Article Synopsis
- Quetiapine Fumarate (QF) is a poorly absorbed atypical antipsychotic, prompting the design of PEG-functionalized graphene oxide nanosheets (GON) for better nasal delivery.
- The study utilized a modified Hummers process to synthesize GON, then created PEG-GON through carbodiimide chemistry, and attached QF using π-π stacking to form QF@PEG-GON, which underwent various characterizations and studies.
- The resulting nanocomposite demonstrated significant mucoadhesion, a drug loading content of 9.2%, and achieved a 43.82% drug release within 24 hours, suggesting its potential as an effective nasal delivery system for QF.
