Visual detection and efficient capture of hydrogen chloride and ammonia vapours by a sustainable dual emissive metal-organic framework.

A convenient, fast, selective, sustainable detection and capture of hydrochloric acid and ammonia vapours in the solid state with bare eye colour switching is observed by a robust microporous 2D zigzag Zn-MOF based material. Here ESIPT off/on based dual emission alteration has been employed for sensing.

Metal-free electrocatalytic upcycling of polyethylene terephthalate plastic to C products.

Polyethylene terephthalate (PET) is one of the most used polymers, but the non-degradable and persistent nature of PET waste in the environment is a global menace. Hence upcycling PET waste becomes indispensable. Herein, we introduce the first metal-free electrochemical-upcycling of PET into value-added chemicals and H fuel using an organo-electrocatalyst (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl (TEMPO).

Terpenoids as potential phytoconstituent in the treatment of diabetes: From preclinical to clinical advancement.

Background: Diabetes mellitus, a hyperglycemic condition associated with multitudinous organ dysfunction, is a hallmark of the metabolic disorder. This life-threatening condition affects millions of individuals globally, harming them financially, physically and psychologically in the course of therapy.

Purposes: The course therapy for illnesses has undergone ground-breaking transformations due to recent technical advances and insights.

Single-Crystal P2-NaMnNiO Cathode Material with Improved Cycling Stability for Sodium-Ion Batteries.

Layered oxides constitute one of the most promising cathode materials classes for large-scale sodium-ion batteries because of their high specific capacity, scalable synthesis, and low cost. However, their practical use is limited by their low energy density, physicochemical instability, and poor cycling stability. Aiming to mitigate these shortcomings, in this work, we synthesized polycrystalline (PC) and single-crystal (SC) P2-type NaMnNiO (NMNO) cathode materials through a solid-state route and evaluated their physicochemical and electrochemical performance.

Morphologically tuned CuO-ZnO-CeO catalyst for CO hydrogenation to methanol.

Morphologically modified composite CuO-ZnO-CeO catalysts were synthesized using a single-step hydrothermal technique. The study highlights the influence of solvent on the structural and physico-chemical properties of the catalysts. Various techniques, such as XRD, FE-SEM, BET, XPS, and H-TPR, were used to analyze the catalyst properties.

Selective Detection of Primary Aromatic Amines through Enhanced Luminescence of a 2D + 2D Inclined Polycatenated Microporous Nitro-Functionalized Metal-Organic Framework.

Detection and sensing of amines through enhanced fluorescence emission are always challenging in aqueous solution. The range of different Lewis basicities, shapes, and sizes as well as the different structural arrangements of amines is responsible for their less specificity in aqueous solution. Here, we have designed a highly fluorescent emissive 2D + 2D → 3D inclined polycatenated NO-functionalized flexible metal-organic framework (MOF) for selective segregation of electron-rich aromatic primary amines from electron-deficient amines in aqueous solution, showing different emission behaviors.

Modulation of Estrogen Receptor Alpha (ERα) and Tumor Suppressor Gene BRCA1 in Breast Cancer Cells by Bazedoxifene Acetate (BZA).

Selective estrogen receptor modulators (SERMs) are steroid analogs with dual functionality, acting as partial estrogen receptor agonists to preserve postmenopausal bone density and as estrogen receptor antagonists in breast tissue. Bazedoxifene acetate (BZA) is an FDA-approved, third-generation SERM used in the treatment of osteoporosis in women. It demonstrates potential as a therapeutic option for breast cancer patients undergoing endocrine therapy.

Cooperative dissolution of peptidomimetic vesicles and amyloid β fibrils.

The aggregation of amyloid proteins in the brain is a significant neurotoxic event that contributes to neurodegenerative disorders. The aggregation of amyloid beta (Aβ), particularly Aβ42 monomers, into various forms such as oligomers, protofibrils, fibrils, and amyloid plaques is a key pathological feature in Alzheimer's disease. As a result, Aβ42 is a primary target and the development of molecular strategies for the dissolution of Aβ42 aggregates is considered a promising approach to mitigating Alzheimer's disease pathology.

Improving rechargeable magnesium batteries through dual cation co-intercalation strategy.

The development of competitive rechargeable Mg batteries is hindered by the poor mobility of divalent Mg ions in cathode host materials. In this work, we explore the dual cation co-intercalation strategy to mitigate the sluggishness of Mg in model TiS material. The strategy involves pairing Mg with Li or Na in dual-salt electrolytes in order to exploit the faster mobility of the latter with the aim to reach better electrochemical performance.

Electro-Oxidation Reaction of Methanol over LaSrNi(Mn/Fe/Co)O Ruddlesden-Popper Oxides.

Solution combustion-synthesized Ruddlesden-Popper oxides LaSrNi(Mn/Fe/Co)O were explored for the methanol electro-oxidation reaction. With optimal doping of Sr in the A site and Co in the B site, Ni with t configuration in LaSrNiCoO exhibited a tetragonal distortion with compression in axial bonds and elongation in equatorial bonds. This structural modification fostered an augmented overlap of orbitals with axial O 2p orbitals, leading to a heightened density of states at the Fermi level.

One-Step Conversion of n-Butanol to Aromatics-free Gasoline over the HZSM-5 Catalyst: Effect of Pressure, Catalyst Deactivation, and Fuel Properties as a Gasoline.

Sustainable production of gasoline-range hydrocarbon fuels from biomass is critical in evading the upgradation of combustion engine infrastructures. The present work focuses on the selective transformation of n-butanol to gasoline-range hydrocarbons free from aromatics in a single step. Conversion of n-butanol was carried out in a down-flow fixed-bed reactor with the capability to operate at high pressures using the HZSM-5 catalyst.

Solid-State Solvent-Independent Excited-State Intramolecular Proton Transfer in a Coordination Polymer and Its Temperature Dependence.

Increasing demand for futuristic switches and sensors around the world has created an intense interest in smart materials, which can show a rapid but feature-dependent change in the physical properties in the presence of external stimuli. Hitherto such changes in the photophysical property of materials, specifically in the solid state, are projected for the use of smart on-off switches. Materials having an external-stimuli-responsive change in the photophysical properties like excited-state intramolecular proton transfer (ESIPT) can also be utilized for these purposes.

Electron transfer catalysis mediated by 3d complexes of redox non-innocent ligands possessing an azo function: a perspective.

It was first reported almost two decades ago that ligands with azo functions are capable of accepting electron(s) upon coordination to produce azo-anion radical complexes, thereby exhibiting redox non-innocence. Over the past two decades, there have been numerous reports of such complexes along with their structures and diverse characteristics. The ability of a coordinated azo function to accept one or more electron(s), thereby acting as an electron reservoir, is currently employed to carry out electron transfer catalysis since they can undergo redox transformation at mild potentials due to the presence of energetically accessible energy levels.

An overview of anti-SARS-CoV-2 and anti-inflammatory potential of baicalein and its metabolite baicalin: Insights into molecular mechanisms.

The current Coronavirus Disease 2019 (COVID-19) pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is highly contagious infection that breaks the healthcare systems of several countries worldwide. Till to date, no effective antiviral drugs against COVID-19 infection have reached the market, and some repurposed drugs and vaccines are prescribed for the treatment and prevention of this disease. The currently prescribed COVID-19 vaccines are less effective against the newly emergent variants of concern of SARS-CoV-2 due to several mutations in viral spike protein and obviously there is an urgency to develop new antiviral drugs against this disease.

Harnessing the potential of probiotics in the treatment of alcoholic liver disorders.

In the current scenario, prolonged consumption of alcohol across the globe is upsurging an appreciable number of patients with the risk of alcohol-associated liver diseases. According to the recent report, the gut-liver axis is crucial in the progression of alcohol-induced liver diseases, including steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Despite several factors associated with alcoholic liver diseases, the complexity of the gut microflora and its great interaction with the liver have become a fascinating area for researchers due to the high exposure of the liver to free radicals, bacterial endotoxins, lipopolysaccharides, inflammatory markers, etc.

The Implications of Coupling an Electron Transfer Mediated Oxidation with a Proton Coupled Electron Transfer Reduction in Hybrid Water Electrolysis.

Invited for this month's cover are the groups of Menny Shalom at the Ben-Gurion University of the Negev, Israel and Dr. Biswajit Mondal at Indian Institute of Technology Gandhinagar, India. The image shows the connection between two half-cells: an electron transfer-mediated [(2,2,6,6-tetramethyl-1-piperidin-1-yl)oxyl] (TEMPO)-catalyzed benzylamine oxidation at the anode and a proton-coupled electron transfer at the cathode for hydrogen generation.

Solvent-Mediated Enantioselective Rauhut-Currier Cyclization via Iminium and Enamine Activation.

In this work, we have developed an unconventional and highly enantioselective solvent-promoted Rauhut-Currier cyclization of enal-tethered cyclohexadienone by exploiting the reactivity of a simple Jørgensen-Hayashi catalyst through the merging of iminium and enamine activation. This asymmetric desymmetrization reaction has broad substrate scope in good yields with high to excellent enantioselectivity. DFT calculations suggest that the elimination of the alkoxy group is the rate-limiting step and that it proceeds through proton abstraction by solvent instead of a direct 1,3-proton shift.

Therapeutic potential of green tea catechin, (-)-epigallocatechin-3--gallate (EGCG) in SARS-CoV-2 infection: Major interactions with host/virus proteases.

Background: The current COVID-19 pandemic from the human pathogenic virus SARS-CoV-2 has resulted in a major health hazard globally. The morbidity and transmission modality of this disease are severe and uncontrollable. As no effective clinical drugs are available for treatment of COVID-19 infection till to date and only vaccination is used as prophylaxis and its efficacy is restricted due to emergent of new variants of SARS-CoV-2, there is an urgent need for effective drugs for its treatment.

Reduction of Sulfur Dioxide to Sulfur Monoxide by Ferrous Porphyrin.

The reduction of SO to fixed forms of sulfur can address the growing concerns regarding its detrimental effect on health and the environment as well as enable its valorization into valuable chemicals. The naturally occurring heme enzyme sulfite reductase (SiR) is known to reduce SO to H S and is an integral part of the global sulfur cycle. However, its action has not yet been mimicked in artificial systems outside of the protein matrix even after several decades of structural elucidation of the enzyme.

The Implications of Coupling an Electron Transfer Mediated Oxidation with a Proton Coupled Electron Transfer Reduction in Hybrid Water Electrolysis.

Electrolysis of water is a sustainable route to produce clean hydrogen. Full water-splitting requires a high applied potential, in part because of the pH-dependency of the H and O evolution reactions (HER and OER), which are proton-coupled electron transfer (PCET) reactions. Therefore, the minimum required potential will not change at different pHs.

Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19.

Currently an emerging human pathogenic coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused coronavirus disease 2019 (COVID-19) that has posed a serious threat to public health worldwide. As it is a novel severe pneumonia-type viral disease, no effective therapeutic agents are available to treat this infection to date, emphasizing an urgent need for development of effective anti-SARS-CoV-2 agents. Based on screening in computational biology and biological in vitro assays, a good number of natural compounds and their synthetic analogues have been confirmed to possess target-specific inhibitory effects against the activity of host and viral proteases, namely, cathepsin-L, TMPRSS2, Sec61, Mpro (3CL-protease), RNA-dependent RNA protease (RdRp), helicase cap-binding proteases eEF1A, eIF4A, eIF4E, which play dominant roles in progression of infection and replication of SARS-CoV-2 virus in host cells.

Azo-oximate metal-carbonyl to metallocarboxylic acid the intermediate Ir(III) radical congener: quest for co-ligand driven stability of open- and closed-shell complexes.

The redox non-innocent behavior of the diaryl-azo-oxime ligand L1 has been accentuated the synthesis of metastable anion radical complexes of type -[Ir(L)Cl(CO)(PPh)] 2 (CO is to azo group of the ligand) by the oxidative coordination reaction of 1 with Vaska's complex. The stereochemical role of co-ligands the interplay of π-bonding has been found to be decisive in controlling the aptitude of the coordinated redox non-innocent ligand to accept or reject an electron. This has been clarified the isolation of quite a few complexes as well as the failure to synthesize some others.