The use of analgesics for intentional self-poisoning: Trends in U.S. poison center data.

In the U.S., intentional self-poisonings with analgesics that are available without a prescription increased from 2000 to 2018.

Risk of hospitalized depression and intentional self-harm with brand and authorized generic sertraline.

Background: Recent suggestions of therapeutic inequivalence of brand and generic sertraline have raised concerns about disproportionately higher adverse events among generic users.

Objective: To assess the impact of confounding in a comparison of the risks of worsening depression and intentional self-harm (ISH) between users of brand name sertraline and its pharmaceutically equivalent authorized generic (AG).

Methods: Using a retrospective new-user cohort design, we identified patients with a diagnosis code for depression aged ≥12 years who were continuously enrolled in a Sentinel Data Partner health plan for ≥180 days before their first sertraline dispensing between June 30, 2006 and September 30, 2015.