Publications by authors named "Dinara Ryspayeva"
Purpose: A multicenter, randomized, open-label, phase II study (HERIZON; NCT02795988) was conducted to evaluate the clinical and immunologic efficacy of HER-Vaxx (IMU-131), a B-cell, peptide-based vaccine targeting HER2 overexpressed in 6% to 30% of gastroesophageal adenocarcinomas (GEA).
Patients And Methods: Patients (n = 36) with GEA were treated with standard-of-care chemotherapy (n = 17) or HER-Vaxx plus chemotherapy (n = 19), using the recommended phase 2 dose for the vaccine. Overall survival (OS; primary endpoint), safety, progression-free survival (PFS), clinical response (secondary endpoints), and vaccine-induced HER2-specific antibody levels in serum and correlation with tumor response rates (exploratory endpoints) were investigated.
Apoptosis is a form of programmed cell death that is mediated by intrinsic and extrinsic pathways. Dysregulation of and resistance to cell death are hallmarks of cancer. For over three decades, the development of therapies to promote treatment of cancer by inducing various cell death modalities, including apoptosis, has been a main goal of clinical oncology.
View Article and Find Full Text PDFArticle Synopsis
- The article analyzes how the concept of 'family' is expressed in Kazakh, Russian, and English cultures through various linguistic methods, including dictionary definitions and proverbs.
- It utilizes several research techniques, such as component analysis and psycholinguistic experiments, to explore the complex nature of the 'family' concept in these languages.
- The findings suggest that understanding the 'family' concept is essential for grasping its impact on both societal structures and individual identities.
Background: Conventionally, breast cancer (BC) prognosis and prediction of response to therapy are based on TNM staging, histological and molecular subtype, as well as genetic alterations. The role of various epigenetic factors has been elucidated in carcinogenesis. However, it is still unknown to what extent miRNAs affect the response to neoadjuvant chemotherapy (NACT).
View Article and Find Full Text PDFPurpose: To identify predictive factors connected with pathologic response in patients with breast cancer (BC) having received neoadjuvant chemotherapy (NACT).
Methods: 49 patients with BC were investigated before and after treatment in this prospective research. Different chemotherapy regimes were administered.