Development and characterization of bael fruit gum-pectin hydrogel for enhanced antimicrobial activity.

Natural polymers are crucial for developing sustainable biomedical solutions, as their bioactivity, biocompatibility, and biodegradability make them superior alternatives to synthetic materials. The objective of the study is to develop and characterize a chemically modified bael fruit gum (BFG) and pectin hydrogel to enhance antimicrobial activity. Due to BFG's anionic nature, it was chemically modified to introduce cationic groups, facilitating cross-linking with pectin.

Polysaccharide mediated nanodrug delivery: A review.

Polysaccharides have drawn a lot of attention due to their potential as carriers for drugs and other bioactive chemicals. In drug delivery systems, natural macromolecules such as polysaccharides are widely utilized as polymers. This utilization extends to various polysaccharides employed in the development of nanoparticles for medicinal administration, with the goal of enhancing therapeutic efficacy while minimizing side effects.

Exploration of L. seed mucilage into floating drug delivery system.

The aim of the present study was to explore L. seed mucilage as a natural polymer in controlled release floating drug delivery system. First, seed mucilage was extracted and evaluated for phytochemical screening, solubility studies, swelling index, viscosity and surface tension.

Discovery of pyridoindole derivatives as potential inhibitors for phosphodiesterase 5A: and studies.

The aim of this work was to synthesise derivatives from identified plant based pyridoindole lead scaffold, and to assess phosphodiesterase 5A inhibitory potential by and . Pyridoindole derivatives were synthesised by using six-stage reactor. screening was carried out by grip-based docking methodology.

Discovery of potential inhibitors for phosphodiesterase 5A, sodium-potassium pump and beta-adrenergic receptor from : approach.

The aim of this work was to perform analysis of selected biomolecules from () by using virtual screening, molecular docking and pharmacophore modeling. Reported 30 biomolecules of were used as ligands. Grip-based docking was carried out to produce the target-specific complex model using vLife MDS 4.

Development of stable emulsified formulations of for topical application: evaluation of antioxidant activity of final product and molecular docking study.

The aim of this work was to develop stable emulsified formulations containing () extract and to assess antioxidant potential of the final product with molecular screening. emulsified formulations were prepared by application of ternary phase diagram design and were evaluated for phytochemical screening, solubility studies, permeation study, DPPH free radical scavenging assay, anti-tyrosinase activity, skin irritation, stability studies, molecular docking study, and pharmacophore modeling. Phytochemical screening resulted in the presence of secondary metabolites.

Enhancement in in vitro anti-angiogenesis activity and cytotoxicity in lung cancer cell by pectin-PVP based curcumin particulates.

The aim of this work was to prepare pectin-poly (vinyl pyrrolidone) [PVP] based curcumin particulates to enhance the anticancer potential of curcumin, solubility and allow its localized controlled release. Pectin-PVP based curcumin particulates (PECTIN-PVP CUR) were prepared by spray drying technique in different ratios and were evaluated for surface morphology, micromeritics, flowability, particle size, drug content, in vitro dissolution, inhalable fraction, anti-angiogenesis/angiolysis and cytotoxicity. Results of micromeritic properties, Carr's index, Hausner's ratio and angle of repose were satisfactory.

Effect of ritanserin and leuprolide alone and combined on marble-burying behavior of mice.

Obsessive-compulsive disorder (OCD) is characterized by absurd, recurrent thoughts (obsessions) followed by certain stereotyped actions (compulsions). OCD can impair all areas of brain functioning and produce devastating effects on patients and their families. Marble-burying behavior of mice is a well-accepted paradigm to screen anti-compulsive activity.