Publications by authors named "Dinakshi Shah"
Introduction: Despite octogenarians representing an ever-increasing proportion of patients with lung cancer, there is a paucity of evidence describing outcomes after lung resection for these patients. We aimed to evaluate short and mid-term outcomes for octogenarians after lung resection.
Materials And Methods: A total of 5,470 consecutive patients undergoing lung resection for primary lung cancer from 2012-2019 in two UK centres were included.
Phase 3 trials have established standard first-line (1L) and 2L systemic therapy options for patients with advanced biliary cancer (ABC). However, a standard 3L treatment remains undefined. Clinical practice and outcomes for 3L systemic therapy in patients with ABC were therefore evaluated from three academic centres.
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- Pancreatic exocrine insufficiency (PEI) is commonly observed in patients with advanced pancreatic cancer (aPC), but there is no standard method for screening it effectively.
- A study involved assessing patients with aPC through various dietary and nutritional tests, aiming to develop and validate a screening tool for PEI.
- Results showed that 64% of patients had PEI, identified by the new screening tool, which was associated with shorter survival rates; the tool proved feasible for clinical use, with high patient satisfaction.*
Use of the Rockwood Clinical Frailty Scale in patients with advanced hepatopancreaticobiliary malignancies.
Expert Rev Anticancer Ther
September 2022
Background: Co-existing frailty in older patients with hepatopancreaticobiliary (HPB) malignancies is common. This study assessed the relationship between the Rockwood Clinical Frailty scale (CFS) and systemic anti-cancer therapy dose intensity (SACT-DI) and overall survival (OS) in patients with advanced HPB malignancies.
Research Design And Methods: CFS was assessed prospectively for consecutive patients with newly diagnosed advanced HPB malignancy (The Christie; Sep-2019 to June-2020).
Introduction: A proportion of patients with lung cancer will not be suitable for anti-cancer treatment and are managed with best supportive care (BSC). The aim of this retrospective case series analysis was to critically review the use of diagnostic and staging investigations in patients who were ultimately managed with BSC.
Methods: A retrospective review of all lung cancer patients with a multidisciplinary team outcome of BSC from 01 June 2018 to 01 June 2019 was performed.
Article Synopsis
- Cardiac catheter ablation is a common treatment for supraventricular tachycardia (SVT), but this study investigated the risk of deep vein thrombosis (DVT) following the procedure.
- A cohort of 80 patients, who were not on anticoagulants before the procedure, was monitored for DVT using ultrasound at 24 hours and again between 10 to 14 days post-ablation.
- The study found that 8.8% of patients developed DVT in the leg where the catheter was inserted, particularly among those with elevated D-dimer levels, suggesting the potential need for preventive anticoagulation during the procedure.
Tumour tissue as a source for molecular profiling and for in vivo models has limitations (e.g., difficult access, limited availability, single time point, potential heterogeneity between primary and metastatic sites).
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