Addition of Camellia sinensis extract to water to disinfect respiratory viruses accumulated over different surfaces.

New precautions have become part of our daily life since COVID-19 pandemic such as wearing masks, maintaining distance and disinfecting products bought from markets before using them which is exhausting. We aimed to test the inhibitory effect of Camellia sinensis (black tea) water extracts on respiratory viruses and the inhibition of viruses accumulated over different surface types after being soaked in water supplemented with the extracts. Two water extraction methods (extract A: maceration at 80 °C for 30 min and extract B: boiling for 40 min) were applied; extracts were analyzed by high-performance liquid chromatography to detect polyphenolic compounds.

Triazolopyrimidines and Thiazolopyrimidines: Synthesis, Anti-HSV-1, Cytotoxicity and Mechanism of Action.

Background: Several commercial drugs utilized in the treatment of HSV containing pyrimidine moiety. Because of the ineffectiveness of virus drugs due to the resistance of the patient's immune system, there is a pressing need to prepare new compounds that are effective in the treatment of various viruses.

Results: Merged pyrimidine derivatives were designed by one pot synthesis of pyrimidinethione derivative with halogenated compounds.

Anti-HSV-1 activity and mechanism of action of some new synthesized substituted pyrimidine, thiopyrimidine and thiazolopyrimidine derivatives.

A series of heterocyclic derivatives 2-16 conjugated with tetrahydronaphthalene moiety were synthesized as antiviral agents by using 1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone as starting material. The antiviral screening showed that many of these obtained compounds have good antiviral activities comparable to Acyclovir as reference control. Two compounds 13 and 15 gave over 90% inhibition and considered to be highly promising and on confirming their activity and comparing them to antiviral activity of Acyclovir.