Publications by Dina Mohamed El Samman

Publications by authors named "Dina Mohamed El Samman"

J Pathol Transl Med

November 2021

Glioblastoma is a highly aggressive brain tumor linked to poor patient outcomes, with PD-L1/PD-1 interactions contributing to immune evasion.
In a study of 30 glioblastoma cases, PD-L1 was widely expressed, while CD8-positive lymphocytes showed lower expression; higher PD-L1 levels correlated to worse survival rates.
The findings suggest that PD-L1 is a crucial biomarker for prognosis in glioblastoma patients, as it independently affects progression-free survival and overall survival outcomes.

- Dina Mohamed El Samman's recent research focuses on the immunohistochemical expression of programmed death-ligand 1 (PD-L1) and CD8 in glioblastomas, highlighting the immune evasion mechanisms of this aggressive brain tumor type.
- Her 2021 study suggests that glioblastoma tumors may utilize the PD-L1/PD-1 interaction to evade immune responses, indicating a potential area for therapeutic intervention.
- The research identifies PD-L1 as a promising predictive biomarker for the effectiveness of PD-L1/PD-1 blockade treatments, which could enhance treatment strategies for patients with glioblastomas.