Synopsis of recent research by authors named "Dina M Sigano"
- Dina M Sigano's recent research focuses on the development of novel therapeutic strategies for central nervous system diseases and viral infections, highlighting the potential of natural products and synthetic compounds as inhibitors and modulators of critical biological processes.
- Key findings include the identification of botryllamide G as a viable ABCG2 inhibitor to enhance lapatinib delivery to the brain, and the discovery of alternative receptors for JC polyomavirus entry, which could inform new approaches to preventing progressive multifocal leukoencephalopathy (PML).
- Additionally, her work has detailed the design of potent HIV-1 maturation inhibitors and explored the chemical properties of diacylglycerol-lactones and ceramide analogs as they relate to biological activity, indicating significant pathways for drug development in treating cancer and infectious diseases.
