Metabolomic Profiling and In Vivo Antiepileptic Effect of Aerial Parts and Roots Crude Extracts against Pentylenetetrazole-Induced Kindling in Mice.

The chemical profiles of both () aerial parts and roots extracts were evaluated with LC-ESI-TOF-MS/MS analysis. Twenty-four compounds were detected. Among them, some are detected in both the aerial parts and the roots extracts, and others were detected in the aerial parts only.

A New Saponin (Zygo-albuside D) from Roots Triggers Apoptosis in Non-Small Cell Lung Carcinoma (A549 Cells) through CDK-2 Inhibition.

Phytochemical study of the ethyl acetate root extract of has resulted in the isolation of a new saponin, Zygo-albuside D (), along with two known compounds; (3-O-[β-D-quinovopyranosyl]-quinovic acid) (), which is first reported in the root, and catechin (), first reported in the genus. Their chemical structures were established by NMR and high-resolution mass spectrometry (HRMS). The new saponin () exhibited promising cytotoxicity with IC values of 3.

Comparative Cytotoxic Evaluation of Root and Aerial Parts of Different Extracts and Their Biosynthesized Silver Nanoparticles on Lung A549 and Prostate PC-3 Cancer Cell Lines.

The current work demonstrates a comparative study between aerial and root parts of L. The total phenolic (TPC) and flavonoid content (TFC), in addition to the antioxidant activity, of the crude extracts were investigated, where the aerial parts revealed a higher value overall. By means of UV-VIS and HPLC, rutin and caffeic acid were detected and then quantified as 5.

Zygo-Albuside A: New Saponin from L. with Significant Antioxidant, Anti-Inflammatory and Antiapoptotic Effects against Methotrexate-Induced Testicular Damage.

Chemical investigation of the crude extract of the aerial part of L. () led to the isolation of a new saponin, Zygo-albuside (), together with seven known compounds, one of them (caffeic acid, compound ) is reported in the genus for the first time. NMR (1D and 2D) and mass spectrometric analysis, including high-resolution mass spectrometry (HRMS), were utilized to set up the chemical structures of these compounds.

New Cytotoxic Cerebrosides from the Red Sea Cucumber Supported by Studies.

Bioactivity-guided fractionation of a methanolic extract of the Red Sea cucumber and LC-HRESIMS-assisted dereplication resulted in the isolation of four compounds, three new cerebrosides, spiniferosides A (), B (), and C (), and cholesterol sulfate (). The chemical structures of the isolated compounds were established on the basis of their 1D NMR and HRMS spectral data. Metabolic profiling of the extract indicated the presence of diverse secondary metabolites, mostly hydroxy fatty acids, diterpenes, triterpenes, and cerebrosides.