Building Ultra-High-Density Linkage Maps Based on Efficient Filtering of Trustable Markers.

The study is focused on addressing the problem of building genetic maps in the presence of ∼10-10 of markers per chromosome. We consider a spectrum of situations with intrachromosomal heterogeneity of recombination rate, different level of genotyping errors, and missing data. In the ideal scenario of the absence of errors and missing data, the majority of markers should appear as groups of cosegregating markers ("twins") representing no challenge for map construction.