Publications by authors named "Dina Bogoslavski"
Article Synopsis
- Exercise leads to the secretion of irisin from muscles, which has cognitive benefits and helps combat neurodegeneration.
- A study uncovered that the heat shock protein eHsp90α released during exercise activates the integrin αVβ5, enhancing irisin's ability to bind and signal effectively.
- Researchers created a detailed model of the irisin and αVβ5 interaction, revealing a unique binding site for irisin, which highlights a new way small polypeptide hormones can interact with integrin receptors.
Article Synopsis
- * Traditional proteomics faces challenges due to the presence of abundant proteins in serum, which makes it hard to detect those present in lower amounts, but extracellular fluid (EF) from muscle and fat shows distinct protein profiles.
- * By analyzing EFs from mice under different conditions like exercise, researchers discovered new proteins (including prosaposin) that can stimulate key processes in fat cells, showcasing the potential of EF isolation for discovering new myokines and adipokines.
Article Synopsis
- Adaptive thermogenesis can increase energy expenditure and help combat obesity and diabetes by utilizing thermogenic fat cells.
- New research shows that these fat cells use an enzyme called tissue-nonspecific alkaline phosphatase (TNAP) to engage in a process called futile creatine cycling, which releases energy as heat.
- In experiments, inhibiting TNAP reduces energy expenditure and promotes obesity in mice, highlighting its essential role in metabolic processes within thermogenic fat cells.
Mitochondrial abundance and function are tightly controlled during metabolic adaptation but dysregulated in pathological states such as diabetes, neurodegeneration, cancer, and kidney disease. We show here that translation of PGC1α, a key governor of mitochondrial biogenesis and oxidative metabolism, is negatively regulated by an upstream open reading frame (uORF) in the 5' untranslated region of its gene (PPARGC1A). We find that uORF-mediated translational repression is a feature of PPARGC1A orthologs from human to fly.
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