Publications by authors named "Dina A Zamzam"
Multiple sclerosis (MS) is a chronic autoimmune disease where activated immune cells can attack oligodendrocytes causing damage to the myelin sheath. Several molecular mechanisms are responsible for the auto-activation of immune cells such as RNA interference (RNAi) through microRNAs (miRNAs or miRs). In the present study, the role of miR-155 in regulating CD8 T-cell activity in patients with relapsing-remitting multiple sclerosis (RRMS) was investigated, in terms of its migratory functions with regard to intracellular adhesion molecule-1 (ICAM1) and integrin subunit β2 (ITGB2), and its cytotoxic proteins, perforin and granzyme B.
View Article and Find Full Text PDFArticle Synopsis
- Multiple Sclerosis (MS) is a chronic disease affecting the central nervous system, with Relapsing-Remitting Multiple Sclerosis (RRMS) being the most common type, leading to disabilities assessed by the Expanded Disability Status Scale (EDSS).
- CD8+ T cells play a significant role in MS by expressing crucial proteins (ICAM1, ITGB2) that assist in crossing the blood-brain barrier and include cytotoxic elements (perforin, granzymeB) that damage brain cells.
- The study discovered lower levels of miR-155 and higher levels of surface receptors and cytotoxic proteins in CD8+ T cells from RRMS patients, indicating their potential as biomarkers for disease severity and insights into
Background: Assessment of multiple sclerosis (MS) patients during the era of the coronavirus disease 2019 (COVID-19) pandemic was confronted with the overwhelmed healthcare facilities in Egypt and fear of the patients to get infected while attending the follow-up visits. This study aimed to assess the value of telephone-based assessments in the follow-up of MS patients. It includes one hundred and five patients who participated in the study and completed 3 telephone-based assessments which are the Hauser Ambulation index, Multiple Sclerosis Neuropsychology Questionnaire (MSNQ), and Symptoms of Multiple Sclerosis Scale (SMSS).
View Article and Find Full Text PDFBackground: The aim of this work was to identify the magnetic resonance imaging (MRI) markers of disability in Egyptian multiple sclerosis (MS) patients.
Subjects And Methods: This retrospective observational study included 673 patients recruited from the registry of the MS unit at Ain Shams University hospitals. At the time when the MRI scans of the brain and spinal cord were done (with and without gadolinium enhancement), clinical disability was rated using the Expanded Disability Status Scale (EDSS) during the patient's first visit.
Background: Epidemiological studies of multiple sclerosis (MS) are lacking in Egypt.
Objective: To study the characteristics of Egyptian patients with multiple sclerosis in a new registry in a major tertiary referral centre in Cairo, Egypt.
Subject And Methods: Patients were from the project MS database of the Multiple Sclerosis Unit at Ain Shams University Hospitals (N=950).