Effect of CYP3A4*22, CYP3A5*3 and POR*28 genetic polymorphisms on calcineurin inhibitors dose requirements in early phase renal transplant patients.

Objective: This study aimed to investigate the combined effect of CYP3A5*3, CYP3A4*22, and POR*28 genetic polymorphisms on tacrolimus and cyclosporine dose requirements.

Methods: One hundred thirty renal transplant patients placed on either tacrolimus or cyclosporine were recruited, where the effect of CYP3A5*3, CYP3A4*22, and POR*28 genetic polymorphisms on their dose requirements were studied at days 14, 30, and 90 post-transplantations.

Results: The POR*28 allele frequency in the studied population was 29.

Investigation the effect of different ionic liquids based-aryl imidazole on the onset precipitation of asphaltene.

Precipitation and deposition of asphaltene are considered as catastrophic issues facing the petroleum industry. Asphaltene deposition mainly occurs at variety places such as formation pore spaces, pumps, pipelines, wellbore, wellhead, tubing, surface facilities and safety valves causing operational problems, production deficiencies and enormous economic losses. This work aims to study the effect of series of synthesized aryl ionic liquids (ILs) containing different alkyl chains, named as R-IL, R-IL, R-IL, and R-IL, on the onset precipitation point of asphaltene in crude oil.

Influence of CYP3A4*22 and CYP3A5*3 combined genotypes on tacrolimus dose requirements in Egyptian renal transplant patients.

Background: Tacrolimus is a widely prescribed immunosuppressant agent for kidney transplantation. However, optimal dosing is challenging due to its narrow therapeutic index, potentially serious adverse effects, and wide inter-individual variability in pharmacokinetics. Cytochrome P450 3A (CPY3A) enzymes metabolize tacrolimus, so allelic variants such as CYP3A4*22 and CYP3A5*3 may contribute to individual differences in pharmacokinetics and therapeutic efficacy of tacrolimus.

Role of germanium L-cysteine alpha-tocopherol complex as stimulator of some antioxidant defense systems in gamma-irradiated rats.

This study was conducted to evaluate the potency of the newly prepared germanium L-cysteine-alpha-tocopherol complex [germanium dichloro tetrakis (L-cysteinyl-alpha-tocopherol amide) dichloride] as a protective agent against gamma-irradiation-induced free radicals production and liver toxicity. Male Swiss albino rats were injected intraperitoneally with the germanium complex in a concentration of 75 mg kg(-1) body mass per dose, for 6 successive doses, last dose administered twenty minutes pre-exposure to a single dose of whole body y-irradiation of 6.5 Gy.