Determination of correlation between cytokines IL 6, IL8, IL10, IL12, IL17 and severity of hepatocellular carcinoma in patients having hepatitis C.

Objectives: To determine the correlation between the levels of interleukins 6, 8, 10, 12 and 17 and the severity of hepatocellular carcinoma in patients positive for hepatitis C.

Methods: The retrospective, cross-sectional, analytical study was conducted at the Department of Medicine, Mardan Medical Complex, Mardan, Khyber Pakhtunkhwa, Pakistan, and comprised data of hepatocellular carcinoma patients who were positive for hepatitis C on polymerase chain reaction test from March 2021 to December 2022. A control group of healthy patients was also included.

A quality assessment and systematic review of clinical practice guidelines on hormone replacement therapy for menopause using the AGREE II instrument.

Clinical Practice Guidelines (CPGs) have an indispensable role in guiding the selection of treatments for menopause. Variations in guidelines can impact treatments and health outcomes. The aim of this study was to assess CPGs on hormone replacement therapy (HRT) for menopause, systematically reviewing their quality and compiling recommendations for HRT usage.

Magnetic resonance imaging phantom-based S1 vertebral scores are indicators of fat-water-like osteoporotic changes in postmenopausal women: a pilot study.

Study Design: A prospective study.

Purpose: To assess fat-water-like tissue changes on the 1st sacral vertebra using novel magnetic resonance imaging (MRI) phantombased F- and W-scores and evaluate their diagnostic performances in osteoporosis detection.

Overview Of Literature: Using an uncommonly advanced MRI technique, previous studies have found that fat-water changes were consistent with osteoporosis.

Telangiectasias, recurrent epistaxis and a strong family history-a case of Osler- Weber-Rendu Syndrome in Pakistan.

Osler-Weber-Rendu syndrome or Hereditary Haemorrhagic Telangiectasia (HHT) is a rare condition, with very few reported cases, especially in Pakistan. As healthcare workers, we encounter multiple cases of recurrent epistaxis in the emergency as well as outpatient departments. However, patients are usually treated symptomatically without a thorough workup.

Corrigendum: Sesquiterpene lactones attenuate paclitaxel resistance via inhibiting MALAT1/STAT3/ FUT4 axis and P-Glycoprotein transporters in lung cancer cells.

[This corrects the article DOI: 10.3389/fphar.2022.

Assessing osteoporosis in postmenopausal women: preliminary results using a novel lumbar spine phantom-based MRI scoring method.

Objective: To develop a novel magnetic resonance imaging (MRI) phantom for producing F-score (for fat) and W-score (for water) and to evaluate the performance of these scores in assessing osteoporosis and related vertebral fractures.

Materials And Methods: First, a real-time phantom consisting of oil and water tubes was manufactured. Then, 30 female volunteers (age: 62.

Bortezomib Is Effective in the Treatment of T Lymphoblastic Leukaemia by Inducing DNA Damage, WEE1 Downregulation, and Mitotic Catastrophe.

T lymphoblastic leukemia (T-ALL) is an aggressive haematolymphoid malignancy comprising 15% of acute lymphoblastic leukemia (ALL). Although its prognosis has improved with intensive chemotherapy, the relapse/refractory disease still carries a dismal prognosis. Thus, there is an urgent need to develop novel therapy for T-ALL.

Stability and numerical analysis via non-standard finite difference scheme of a nonlinear classical and fractional order model.

In this paper, we develop a new mathematical model for an in-depth understanding of COVID-19 (Omicron variant). The mathematical study of an omicron variant of the corona virus is discussed. In this new Omicron model, we used idea of dividing infected compartment further into more classes i.

Biomechanical MRI detects reduced bone strength in subjects with vertebral fractures.

Vertebral fracture is one of the most serious consequences of osteoporosis. Estimation of vertebral strength from magnetic resonance imaging (MRI) scans may provide a new approach for the prediction of vertebral fractures. To that end, we sought to establish a biomechanical MRI (BMRI) method to compute vertebral strength and test its ability to distinguish fracture from non-fracture subjects.

Siponimod As a Novel Inhibitor of Retinal Angiogenesis: In Vitro and In Vivo Evidence of Therapeutic Efficacy.

Sphingosine-1-phosphate (S1P) receptors control endothelial cell proliferation, migration, and survival. Evidence of the ability of S1P receptor modulators to influence multiple endothelial cell functions suggests their potential use for antiangiogenic effect. The main purpose of our study was to investigate the potential of siponimod for the inhibition of ocular angiogenesis in vitro and in vivo.

Mechanical testing and biomechanical CT analysis to assess vertebral flexion strength of Chinese cadavers.

Biomechanical CT (BCT), i.e., quantitative computed tomography-based finite element analysis (QCT-FEA), promises an improved technique over bone mineral density (BMD) in predicting bone strength and the risk of osteoporotic vertebral fractures.

Enhanced magneto-optical rotation of probe field in thermal medium via spontaneous generated coherence.

A four-level double lambda closed atomic configuration is considered to study the polarization plane rotation of the probe beam through cold as well as thermal Rb[Formula: see text] atomic medium by varying the spontaneously generated coherence (SGC). Magnetic field and strong coupling field are applied to the atomic configuration. The light-matter interaction leads to enhanced the magneto-optical rotation.

Sesquiterpene Lactones Attenuate Paclitaxel Resistance Via Inhibiting MALAT1/STAT3/ FUT4 Axis and P-Glycoprotein Transporters in Lung Cancer Cells.

Paclitaxel resistance is a challenging factor in chemotherapy resulting in poor prognosis and cancer recurrence. Signal transducer and activator of transcription factor 3 (STAT3), a key transcription factor, performs a critical role in cancer development, cell survival and chemoresistance, while its inactivation overwhelms drug resistance in numerous cancer types including lung cancer. Additionally, the fucosyltransferase 4 (FUT4) is a crucial enzyme in post-translational modification of cell-surface proteins involved in various pathological conditions such as tumor multidrug resistance (MDR).

A new fuzzy fractional order model of transmission of Covid-19 with quarantine class.

This paper is devoted to a study of the fuzzy fractional mathematical model reviewing the transmission dynamics of the infectious disease Covid-19. The proposed dynamical model consists of susceptible, exposed, symptomatic, asymptomatic, quarantine, hospitalized, and recovered compartments. In this study, we deal with the fuzzy fractional model defined in Caputo's sense.

Coherent Surface Plasmon Hole Burning via Spontaneously Generated Coherence.

Surface plasmon (SP)-induced spectral hole burning (SHB) at the silver-dielectric interface is investigated theoretically. We notice a typical lamb dip at a selective frequency, which abruptly reduces the absorption spectrum of the surface plasmons polaritons (SPP). Introducing the spontaneous generated coherence (SGC) in the atomic medium, the slope of dispersion becomes normal.

Diagnostic Role of Magnetic Resonance Imaging in Low Back Pain Caused by Vertebral Endplate Degeneration.

Low back pain (LBP) is a common health issue worldwide with a huge economic burden on healthcare systems. In the United States alone, the cost is estimated to be $100 billion each year. Intervertebral disc degeneration is considered one of the primary causes of LBP.

Outcome of patients with acute severe necrotizing pancreatitis in a dedicated hepato-biliary unit of Pakistan.

Objective: To analyze the management of severe necrotizing pancreatitis in a specialized center of a lower middle-income country, Pakistan using multiple outcome measures.

Methods: All the patients in this prospective observational study with severe necrotizing pancreatitis being referred to Pak Emirates Military Hospital from January 2017 to December 2019 were followed over the course of their admission. Demographic data and disease outcomes were duly noted.

Global transmission dynamic of SIR model in the time of SARS-CoV-2.

This current work studies a new mathematical model for SARS-CoV-2. We show how immigration, protection, death rate, exposure, cure rate and interaction of infected people with healthy people affect the population. Our model is SIR model, which has three classes including susceptible, infected and recovered respectively.

On nonlinear classical and fractional order dynamical system addressing COVID-19.

This work studies a new SEIR type mathematical model for SARS-CoV-2. We show how immigration, protection, death rate, exposure, cure rate and interaction of infected people with healthy people affect the population. Our model has four classes including susceptible, exposed, infected and recovered respectively.

Mathematical analysis of COVID-19 by using SIR model with convex incidence rate.

This paper is about a new COVID-19 SIR model containing three classes; Susceptible S(t), Infected I(t), and Recovered R(t) with the Convex incidence rate. Firstly, we present the subject model in the form of differential equations. Secondly, "the disease-free and endemic equilibrium" is calculated for the model.

Defining Digital Game-Based Learning for Science, Technology, Engineering, and Mathematics: A New Perspective on Design and Developmental Research.

In the modern age, digital games are widely used as informal media for Science, Technology, Engineering, and Mathematics (STEM) education and medical therapy for game-based learning. Digital games provide learners with a graphical system of interaction that enhances scientific concepts within an enjoyable environment. The vastly increasing number of digital games produced in the market affects the quality of STEM digital games while requiring multidisciplinary expertise.

Study of global dynamics of COVID-19 via a new mathematical model.

The theme of this paper focuses on the mathematical modeling and transmission mechanism of the new Coronavirus shortly noted as (COVID-19), endangering the lives of people and causing a great menace to the world recently. We used a new type epidemic model composed on four compartments that is susceptible, exposed, infected and recovered (SEIR), which describes the dynamics of COVID-19 under convex incidence rate. We simulate the results by using nonstandard finite difference method (NSFDS) which is a powerful numerical tool.