Clinicians' perspectives on the use of artificial intelligence to triage MRI brain scans.

Artificial intelligence (AI) tools can triage radiology scans to streamline the patient pathway and also relieve clinician workload. Validated AI tools can mitigate the delays in reporting scans by flagging time-sensitive and actionable findings. In this study, we aim to investigate current stakeholder perspectives and identify obstacles to integrating AI in clinical pathways.

Enhanced iodinated disinfection byproducts formation in iodide/iodate-containing water undergoing UV-chloramine sequential disinfection: Machine learning-aided identification of reaction mechanisms.

Restricted to the complex nature of dissolved organic matter (DOM) in various aquatic environments, the mechanisms of enhanced iodinated disinfection byproducts (I-DBPs) formation in water containing both I and IO (designated as I/IO in this study) during the ultraviolet (UV)-chloramine sequential disinfection process remains unclear. In this study, four machine learning (ML) models were established to predict I-DBP formation by using DOM and disinfection features as input variables. Extreme gradient boosting (XGB) algorithm outperformed the others in model development using synthetic waters and in cross-dataset generalization of surface waters.

Functional and Radiological Outcome of Anterior Plate Stabilisation of the Sacroiliac Joint in Unstable Pelvic Injury.

Introduction: Sacroiliac joint disruption, resulting from high energy trauma can cause significant morbidity if no proper treatment given. Many techniques can be used to stabilise pelvic ring injuries. We studied the functional and radiological outcome following open reduction and anterior fixation of the sacroiliac joint and agreement between both outcomes.

Human umbilical cord mesenchymal stem cells derived-exosomes alleviate LPS-induced cervical inflammation and epithelial-mesenchymal transition.

Objective: Patients with chronic cervicitis are known to have an increased risk of infection with human papillomavirus (HPV), which is the primary cause of cervical cancer. Inhibition of cervical inflammation may reduce the risk of cervical cancer. This study investigated how human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) attenuated the lipopolysaccharide (LPS)-induced cervical inflammation.

Molecular characterization and risk analysis of Giardia duodenalis assemblages in corticosteroid-treated and non-treated patients in Ismailia, Arab Republic of Egypt.

Background: Giardia duodenalis (G. duodenalis) is an intestinal protozoan parasite of human and animal hosts. The present study investigated and compared the assemblages of G.

Machine Learning Algorithms to Predict the Risk of Rupture of Intracranial Aneurysms: a Systematic Review.

Purpose: Subarachnoid haemorrhage is a potentially fatal consequence of intracranial aneurysm rupture, however, it is difficult to predict if aneurysms will rupture. Prophylactic treatment of an intracranial aneurysm also involves risk, hence identifying rupture-prone aneurysms is of substantial clinical importance. This systematic review aims to evaluate the performance of machine learning algorithms for predicting intracranial aneurysm rupture risk.

Mixed chlorine/chloramines in disinfected water and drinking water distribution systems (DWDSs): A critical review.

Mixed chlorine/chloramines are commonly occurring in real drinking water distribution systems (DWDSs) but often overlooked. This review provides a comprehensive overview of the occurrences, characteristics, analysis methods, and control strategies of mixed chlorine/chloramines in DWDSs. The characteristics of mixed chlorine/chloramine species are summarized for treated water in drinking water treatment plants (DWTPs), secondary disinfection facilities, and DWDSs where different disinfectants could be blended.

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging.

Arterial thrombosis is a leading cause of death and disability worldwide with no effective bioassay for clinical prediction. As a symbolic feature of arterial thrombosis, severe stenosis in the blood vessel creates a high-shear, high-gradient flow environment that facilitates platelet aggregation towards vessel occlusion. Here, we present a thrombus profiling assay that monitors the multi-dimensional attributes of thrombi forming in such biomechanical conditions.

Predictive modeling for the adsorptive and photocatalytic removal of phenolic contaminants from water using artificial neural networks.

Numerous harmful phenolic contaminants are discharged into water that pose a serious threat to environment where two of the most important purification methodologies for the mitigation of phenolic contaminants are adsorption and photocatalysis. Besides cost, each process has drawbacks in terms of productivity, environmental impact, sludge creation, and the development of harmful by-products. To overcome these limitations, the modeling and optimization of water treatment methods is required.

Comparative evaluation of the effects of laser and chemical denture disinfectants on the surface characteristics of CAD-CAM and conventional denture resins: An in vitro experimental study.

Purpose: The purpose of this study was to assess the effect of Ga-Al-Ar diode, Nd:YAG lasers, and chemical disinfectants (NaOCl, vinegar, and Corega) on surface roughness (Ra) and hardness (VHN) of polymethylmethacrylate (PMMA), thermoplastic polyamide, milled and 3D-printed denture base resins.

Materials And Methods: About 432 specimens of PMMA, thermoplastic polyamide, milled, and 3D-printed resins were divided into six subgroups (n = 18): distilled water (control:C), Ga-Al-Ar diode laser (L1), Nd:YAG laser (L2), 1% sodium hypochlorite (NaOCl), vinegar (AA), and Corega (CR). Each specimen's Ra and VHN were measured.

Perceptions of lived in experiences of healthcare workers during COVID-19 Pandemic in a tertiary Care hospital: A perspective from Pakistan.

Objective: This study aimed to explore the perceptions of frontline Healthcare Workers (HCWs) towards managing COVID-19 in Tertiary care hospital in Pakistan.

Method: This qualitative exploratory study was conducted from January to May 2021 at a Tertiary care hospital designated for COVID-19 patients in Rawalpindi Pakistan. Semi-structured in-depth interviews were conducted from twenty six HCWs.

A novel injectable boron doped-mesoporous nano bioactive glass loaded-alginate composite hydrogel as a pulpotomy filling biomaterial for dentin regeneration.

Background: Different materials have been used as wound dressings after vital pulp therapies. Some of them have limitations such as delayed setting, difficult administration, slight degree of cytotoxicity, crown discoloration and high cost. Therefore, to overcome these disadvantages, composite scaffolds have been used in regenerative dentistry.

MXene-Embedded PEDOT:PSS Hole-Transport Material for Lead-Free Perovskite Solar Cells.

Improving the energy alignment between charge-transport layers and the perovskite is crucial for further enhancing the photovoltaic performance of tin-based perovskite solar cells (PSCs). Herein, the role of TiCT MXene in a poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hole transport layer (HTL) on the photovoltaic properties of PSCs is investigated as a function of its concentration. An improved perovskite film formation with reduced pinhole density and a more uniform contact potential difference is noted when MXene is embedded in the PEDOT:PSS HTL.

Synthesis and characterization of etherified cationic starch flocculant derived from Manihot esculenta peel with varying degrees of substitution.

Cationic Manihot esculenta (ME) peel starch was synthesized through etherification method using 3-chloro-2-hydroxypropyl trimethylammonium chloride (CHPTAC) as cationizing monomer. The optimization of the main factors influencing the degree of substitution (DS) was conducted using central composite design (CCD) and response surface methodology (RSM). The factors assessed include CHPTAC concentration, catalyst sodium hydroxide (NaOH) concentration, and reaction time.

Attenuation of phenylnaphthenic acids related to oil sands process water using solar activated calcium peroxide: Influence of experimental factors, mechanistic modeling, and toxicity evaluation.

Refractory naphthenic acids (NAs) are among the primary toxic compounds in oil sands process water (OSPW), a matrix with a complex chemical composition that poses challenges to its remediation. This study evaluated the effectiveness of calcium peroxide (CaO) combined with solar radiation (solar/CaO) as an advanced water treatment process for degrading model NAs (1,2,3,4-tetrahydronaphthalene-2-carboxylic acid, pentanoic acid, and diphenylacetic acid) in synthetic water (STW) and provide preliminary insights in treating real OSPW. Solar light and CaO acted synergistically to degrade target NAs in STW (>67 of synergistic factor) following a pseudo-first-order kinetic (R ≥ 0.

Syzgium cumini seed/poly vinyl alcohol based water resistant biodegradable nano-cellulose composite reinforced with zinc oxide and silver oxide nanoparticles for improved mechanical properties.

The current work explored a comparative study of biodegradable jamun seed/polyvinyl alcohol (JS) nanocomposites reinforced with varying concentrations of ZnO and AgO nano-fillers. The effect of spherical shaped ZnO and AgO nanoparticles (NPs) on the on structure, morphology, swelling and solubility, crystallinity and mechanical properties together with biodegradation performance of the composite films was fully studied. SEM results showed uniform distribution of ZnO and AgO nanofillers into the JS matrix and dense or compact nanocomposite films were formed.

Impact of prosthetic rehabilitation on oral health-related quality of life of Saudi Adults: A prospective observational study with pre-post design.

This study aimed to assess the impact of prosthetic treatment on the quality of life of partially/completely edentulous patients through the Oral Health Impact Profile-14 (OHIP-14) scale. This pre-post observational study was conducted in the College of Dentistry, Imam Abdulrahman Bin Faisal University, Saudi Arabia, between November 2022 and September 2023. Eligible participants were those aged between 26 and 80, in need of prosthetic treatment, and able to complete the questionnaire voluntarily.

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging.

Arterial thrombosis, which represents a critical complication of cardiovascular diseases, is a leading cause of death and disability worldwide with no effective bioassay for clinical prediction. As a symbolic feature of arterial thrombosis, severe stenosis in the blood vessel creates a high-shear, high-gradient flow environment that effectively facilitates platelet aggregation towards vessel occlusion even with platelet amplification loops inhibited. However, no approach is currently available to comprehensively characterize the size, composition and platelet activation status of thrombi forming under this biorheological condition.

Takotsubo cardiomyopathy following pacemaker insertion complicated with polymorphic ventricular tachycardia: a case report.

Background: Takotsubo cardiomyopathy is a novel form of rapidly reversible heart failure occurring secondary to a stressor that mimics an acute coronary event. The underlying etiology of the stressor is highly variable and can include medical procedures. Pacemaker insertion is an infrequent cause of Takotsubo cardiomyopathy.

Ferroptosis and the ubiquitin-proteasome system: exploring treatment targets in cancer.

Ferroptosis is an emerging mode of programmed cell death fueled by iron buildup and lipid peroxidation. Recent evidence points to the function of ferroptosis in the aetiology and development of cancer and other disorders. Consequently, harnessing iron death for disease treatment has diverted the interest of the researchers in the field of basic and clinical research.

Demographic and clinical features of dengue fever infection in Pakistan: a cross-sectional epidemiological study.

Background: Dengue fever caused by dengue virus is a tropical disease and is among the deadliest vector-borne diseases. The humid and hot summers of Pakistan support the probation of the vectors responsible for the transmission of viral and other parasitic diseases.

Methodology: A retrospective study, from 2012- 2019, of dengue infected individuals from the Punjab province of Pakistan was carried out to analyze epidemiology, clinical and laboratory findings of subjects with dengue virus infection.

The potential effects of N-Acyl homoserine lactones on aerobic sludge granulation during phenolic wastewater treatment.

The formation of aerobic granular sludge (AGS) is relatively difficult during the treatment of refractory wastewater, which generally shows small granular sizes and poor stability. The formation of AGS is regulated by N-Acyl homoserine lactones (AHLs)-mediated quorum sensing (QS). However, the potential role of AHLs in AGS formation under the toxic stress of refractory pollutants and the heterogeneity in the distribution and function of AHLs across different aggregates are not well understood.