Having found the unexpected, we should look again: in favor of lung cancer screening.

Lung cancer is a leading cause of morbidity and death in the United States. A 65-year-old female with a 30 pack-year smoking history who requested screening for lung cancer was initially turned down in the absence of screening guidelines. Computed tomography ordered a month later after review of current evidence revealed a 3.

C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues.

Cullin-RING ubiquitin ligases (CRLs) are critical regulators of multiple developmental and cellular processes in eukaryotes. CAND1 is a biochemical inhibitor of CRLs, yet has been shown to promote CRL activity in plant and mammalian cells. Here we analyze CAND1 function in the context of a developing metazoan organism.

Diverse transcription influences can be insulated by the Drosophila SF1 chromatin boundary.

Chromatin boundaries regulate gene expression by modulating enhancer-promoter interactions and insulating transcriptional influences from organized chromatin. However, mechanistic distinctions between these two aspects of boundary function are not well understood. Here we show that SF1, a chromatin boundary located in the Drosophila Antennapedia complex (ANT-C), can insulate the transgenic miniwhite reporter from both enhancing and silencing effects of surrounding genome, a phenomenon known as chromosomal position effect or CPE.

Cullin-RING ubiquitin ligases: global regulation and activation cycles.

Cullin-RING ubiquitin ligases (CRLs) comprise the largest known category of ubiquitin ligases. CRLs regulate an extensive number of dynamic cellular processes, including multiple aspects of the cell cycle, transcription, signal transduction, and development. CRLs are multisubunit complexes composed of a cullin, RING H2 finger protein, a variable substrate-recognition subunit (SRS), and for most CRLs, an adaptor that links the SRS to the complex.