Publications by authors named "Dimka R Hristova"
Unlabelled: Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system characterised with a complex system of interactions between proinflammatory and anti-inflammatory cytokines in its course.
Aim: The aim of the present study was to investigate the serum levels of cytokines TNF-a, IFN-gamma, IL-4 and IL-10 in female patients with MS and healthy individuals, the changes occurring in the relapse and remission phases of the disease and their correlation with the severity of the neurological deficit.
Patients And Methods: Thirty-five women with relapsing-remitting MS were examined.
Background: Health-related quality of life has been increasingly recognized as an important outcome measure for patients with Parkinson's disease because both motor and non-motor symptoms affect patients' functioning and well being.
Objective: To assess the quality of life (QoL) of patients with Parkinson's disease (PD) and to determine the extent of negative impact of disease on various aspects of their lifestyles.
Patients And Methods: A sample of 866 patients with PD, at the mean age of 73.
Standardized mortality ratio and seasonal fluctuations of mortality in Parkinson's disease.
Folia Med (Plovdiv)
September 2009
Unlabelled: In chronic diseases with low lethality and prolonged progression Parkinson's disease (PD), the standardized mortality ratio (SMR) is more informative in comparison with mortality rates which do not reflect adequately the severity of the disease.
Aim: The aim of the study was to determine the standardized mortality ratio, the absolute excess risk and the indices for seasonal fluctuations of mortality in patients with Parkinson's disease.
Material And Methods: The mortality in patients with PD and in the referent population (regardless of cause) was studied over a 3-year period (2002-2004) in the district of Plovdiv, Bulgaria, with mean population of 711,179 people and total number of patients with PD--2274.