and Combined Extracts Cause Immunomodulatory Effects in Lipopolysaccharide-Challenged Rats.

and which belong to the Asteraceae family, are widely used plants in traditional medicine. Their antioxidant, anti-inflammatory, antiviral, antibacterial, and antitumor effects are well known. However, there are no data on the effects of their combination.

Special criminal sanctions for offenders with mental disorders: Tendencies and challenges in Bulgaria and Norway.

This paper provides a comparative discussion of the use of special criminal sanctions for offenders with mental disorders in Bulgaria and Norway. Such sanctions can be used in both countries for offenders that are acquitted by reason of their mental state at the time of the act to prevent them from reoffending. The overall focus is to discuss the tendencies and challenges regarding the institutionalization of people with mental disorders and the use of special criminal sanctions to this end.

Anti-inflammatory and in vitro antioxidant activities of dry extract.

Many chronic somatic and psychiatric diseases are associated with oxidative stress and inflammation, both of which have detrimental effects on human health.

Composition and chronic toxicity of dry methanol-aqueous extract of wild-growing .

Saturejamontana is a wild growing medicinal plant, part of the Lamiaceae family. This herb is well known as a source of phenolic compounds, which can vary in a broad range depending on different factors and exert many pharmacological activities.

Comparison of blood biochemical parameters of four species of vultures.

Vultures play a very important role in ecosystems by feeding on dead animals and preventing the spread of pathogens. In the mid-20 century in Bulgaria, all species of vultures experienced a rapid population decline and conservation measures include captive breeding and release via adaptation aviaries. Knowledge of the baseline blood biochemical parameters is crucial for the care, rehabilitation and prior to the release of endangered birds of prey.

Invasive pulmonary co-infection caused by sp. and , complicated by reactivation in a patient following second allogeneic hematopoietic stem cell transplantation - Case report.

Invasive fungal infections are common complication in hematopoietic stem cell transplant recipients, often leading to high morbidity and mortality rates. Furthermore, when invasive fungal co-infections are diagnosed the prognosis is rarely favorable. Here, we present a rare case of a 47-year-old HIV-negative male with invasive pulmonary co-infection caused by sp.

Polymer Tablet Matrix Systems for the Controlled Release of Dry Leaf Extract.

The aim of the study was to develop polymer matrix tablets with modified release of dry leaf extract and to investigate basic parameters influencing the drug release pattern. To fully assess the statistical significance of the influence of the individual factors in the tablet formulation development as well as the combination of them, Tukey's tests and a complete 3 factor analysis of variance (ANOVA) were applied. The following three factors were studied at three levels (low, medium and high): influence of the hydrophobic/hydrophilic polymer ratio Ethylcellulose (EC)/Hydroxypropyl methylcellulose (HPMC) (40/60, 25/75 and 10/90), influence of HPMC molecular weight (500 kDa, 750 kDa and 1150 kDa), and influence of the compression force applied (1 t, 1.

Effect of Plant Extracts Combinations on TNF-α, IL-6 and IL-10 Levels in Serum of Rats Exposed to Acute and Chronic Stress.

Oxydative stress, anxiety and depression are associated with changes in cytokine levels. Natural products, including individual and combined plant extracts, have the potential to be used in the treatment of neuropsychiatric disorders. The goal of this study is to investigate the effects of two combined plant extracts, rich in flavonoids, on the levels of the cytokines TNF-α, IL-6, and IL-10 in rats subjected to models of acute cold stress and chronic unpredictable stress.

Identifying deficits in Ukrainian law: Forensic psychiatry misuse in proceedings of administrative offenses.

Ukraine is actively denouncing and abandoning its Soviet legacy, with the legal process of decommunization being at the forefront of this process. However, despite Ukraine's ongoing judiciary reformation process amplified by the signing of the Association Agreement between Ukraine and the European Union, Ukraine's legal system still contains inherited Soviet legal deficiencies that allow for human rights violations. Some of the most glaring deficiencies relate to the rules and regulations for assigning and conducting forensic psychiatric examinations in cases of administrative offenses.

Storage of halved strawberry fruits affects aroma, phytochemical content and gene expression, and is affected by pre-harvest factors.

Introduction: Strawberry fruit are highly valued for their aroma which develops during ripening. However, they have a short shelf-life. Low temperature storage is routinely used to extend shelf-life for transport and storage in the supply chain, however cold storage can also affect fruit aroma.

SEM analysis of the endodontic cavity wall after removal of restorative materials used as temporary restoration.

The aim of the present in vitro study was to analyze the endodontic cavity walls for presence of remnants of conventional glass ionomer cement and flowable light cure composite used as temporary restorative materials of endodontically treated teeth. The dentine surface of the access cavity was observed with scanning electron microscopy after the final removal of the temporary restoration using high-speed turbine and diamond bur or ultrasonic device and diamond tip.

Criminal insanity in Bulgaria and Norway: Analysing the prospect of a common approach.

This article raises the question of the prospect of a common approach to mentally ill offenders in Europe, through a comparative discussion of the criminal insanity rules and systems in Norway and Bulgaria. The underlying motivation is to fill a gap in current legal research where the insanity discourse is still to a certain extent nationally oriented. Bulgaria is to date not represented at all in the international discussion of criminal insanity.

Space weather phenomena on heart rate: a study in the Greek region.

Many scientific investigations have focused on how space weather phenomena, taking place in the vicinity of the Earth, may influence different aspects of life on Earth and presumably human health itself. From 2005, the National and Kapodistrian University of Athens has established an important position in the field of these investigations by collaborating with various scientists and Institutes, both international and domestic, in different heliobiological projects. In this work, the Cosmic Ray Group of the National and Kapodistrian University of Athens has co-operated with the medical staff from different hospitals and clinics around the country so as to develop large records of medical data (heart rate) which covers a long time period.

A study of flavonoid composition and antimicrobial activity of from different floristic regions of Bulgaria.

Introduction: Scutellaria extracts and its constituents, especially the characteristic flavonoids such as baicalein and its glycoside baicalin, exhibit significant antimicrobial activity.

Aim: To perform a comparative analysis of flavonoid composition and antimicrobial activity of extracts obtained from aerial parts and roots of Scutellaria altissima from the regions of Mezek and Bachkovo, Bulgaria.

Materials And Methods: 70% ethanol and aqueous extracts of aerial parts and roots of S.

Prediction of survival in infants with congenital diaphragmatic hernia and the response to inhaled nitric oxide.

Unlabelled: The use of inhaled nitric oxide (iNO) in treating pulmonary hypertension in infants with congenital diaphragmatic hernia (CDH) is controversial. Our aims were to identify factors associated with survival in CDH infants and whether this was influenced by the response to iNO. Results of CDH infants treated in a tertiary surgical and medical perinatal centre in a ten year period (2011-2021) were reviewed.

Diphtheria and tetanus seroepidemiology among children in Ukraine, 2017.

Background: The drastic decline of Ukraine's immunization coverage since 2009 led to concerns about potential resurgence diphtheria and tetanus, along with other vaccine-preventable diseases.

Methods: To assess population immunity against diphtheria and tetanus, we tested specimens from the serosurvey conducted in 2017 among children born in 2006-2015, the birth cohorts targeted by the nationwide outbreak response immunization following a circulating vaccine-derived poliovirus type 1 outbreak in Zakarpattya province in 2015. We surveyed four regions of Ukraine, using cluster sampling in Zakarpattya, Sumy, and Odessa provinces and simple random sampling in Kyiv City.

Efficacy of Inotuzumab Ozogamicin plus Ponatinib Followed by Allogeneic Stem Cell Transplantation in a Patient with Relapsed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.

Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) is an aggressive disease with poor outcomes. Despite the incorporation of tyrosine kinase inhibitors (TKIs) in the therapeutic strategies, patients who relapse after chemotherapy plus TKI have poor overall survival (OS) and less chance to proceed to hematopoietic stem cell transplantation (HSCT) which remains the only curative approach. Therefore, new drugs, such as antibody-targeted therapies alone or in combination with TKIs, offer new therapeutic options for those patients.

Phytochemical Composition, Antioxidant and Antimicrobial Activity of the Balkan Endemic (Degen) Velen. (Lamiaceae).

The current study investigates the content of sugars, organic acids, phenolic acids and flavonoids, as well as antioxidant and antimicrobial activity of Balkan-endemic . Glucose was the most abundant sugar in the plant (2.77%), followed by fructose (1.

Metabolite Profile and Antioxidant Activity of Some Species of Genus Scutellaria Growing in Bulgaria.

Until now, the interest to plants from genus in Bulgaria has been focused mainly on the terpenes in them. The purpose of this study is to enrich the information on the composition of the Bulgarian species in terms of both polyphenolic content as well as primary metabolites such as mono-, oligosaccharides and organic acids. An aerial part of three species growing in four low mountain regions of Southern Bulgaria was used.

Mutation of Arabidopsis Copper-Containing Amine Oxidase Gene Alters Polyamines, Reduces Gibberellin Content and Affects Development.

Polyamines (PAs) are essential metabolites in plants performing multiple functions during growth and development. Copper-containing amine oxidases (CuAOs) catalyse the catabolism of PAs and in are encoded by a gene family. Two mutants of one gene family member, , showed delayed seed germination, leaf emergence, and flowering time.

From CO to Bioplastic - Coupling the Electrochemical CO Reduction with a Microbial Product Generation by Drop-in Electrolysis.

CO has been electrochemically reduced to the intermediate formate, which was subsequently used as sole substrate for the production of the polymer polyhydroxybutyrate (PHB) by the microorganism Cupriavidus necator. Faradaic efficiencies (FE) up to 54 % have been reached with Sn-based gas-diffusion electrodes in physiological electrolyte. The formate containing electrolyte can be used directly as drop-in solution in the following biological polymer production by resting cells.

Parasitic Infection Surveillance in Mississippi Delta Children.

Some recent studies suggest ongoing transmission of parasitic diseases in the American South; however, surveys in Mississippi children are lacking. We enrolled 166 children (median age 8 years, range 4-13 years) from the Mississippi Delta region and carried out multi-parallel real-time polymerase chain reaction (PCR) for , , and on their stool samples. Dried blood spots were obtained for multiplex serology antibody detection.