Publications by authors named "Dimitris Margaritopoulos"
Article Synopsis
- Rhythms in endocrine systems are vital, and hormonal disruptions can occur early in diseases, highlighting the need for better measurement techniques beyond traditional single-time blood tests.
- To address this, researchers employed microdialysis and advanced chromatography methods to analyze adrenal hormones over a 24-hour period, involving 214 healthy volunteers and ensuring minimal disruption to their daily lives.
- The study revealed various fluctuations in adrenal steroids like cortisol and aldosterone, and established "dynamic markers" of normalcy based on sex, age, and BMI, which could help identify endocrine disorders.
Cushing's syndrome (CS) is a rare but detrimental endocrine disorder. Early diagnosis and prompt treatment are essential since the duration of hypercortisolism has an adverse impact on the extent of comorbidities and overall survival. The diagnostic approach involves a stepwise process that includes (1) screening and confirming the diagnosis and (2) establishing the aetiology of CS.
View Article and Find Full Text PDFAge-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study.
Lancet Diabetes Endocrinol
July 2022
Article Synopsis
- Researchers looked at how cortisol, a hormone, affects the death rates in people with adrenal incidentalomas, which are growths on the adrenal glands found by accident.
- They studied over 3,600 patients from different countries to see if high cortisol levels linked to more health problems and heart issues.
- The study found that out of the patients, about 10% died over an average of 7 years, and they analyzed other health conditions that might be related to these adrenal growths.
Suprasellar extension independently predicts preoperative pituitary hormone deficiencies in patients with nonfunctioning pituitary macroadenomas: a single-center experience.
Hormones (Athens)
June 2020
Purpose: Nonfunctioning pituitary adenomas (NFPAs) are among the commonest benign tumors of the pituitary. Hypopituitarism is frequently present at the time of diagnosis, and this has been attributed to stalk portal vessel compression and/or destruction of normal anterior pituitary cells. The aim of our study was to examine possible factors at diagnosis associated with the presence of hypopituitarism.
View Article and Find Full Text PDFArticle Synopsis
- The study examined how consuming caffeinated and decaffeinated coffee affects appetite, energy intake, and various metabolic markers in healthy men.
- It involved 16 participants who consumed either type of coffee or water after a standard breakfast and reported their appetite while blood samples were taken for analysis.
- The results indicated no significant short-term effects on appetite or energy intake from coffee consumption, but caffeine did lead to increased cortisol levels, suggesting a stress response.