Publications by authors named "Dimitrios Troumpoukis"
Abracl (ABRA C-terminal-like protein) is a small, non-typical winged-helix protein that shares similarity with the C-terminal domain of the protein ABRA (Actin-Binding Rho-Activating protein). The role of Abracl in the cell remains elusive, although in cancer cells, it has been implicated in proliferation, migration and actin dynamics. Our previous study showed that mRNA was expressed in the dividing cells of the subpallial subventricular zone (SVZ), in the developing cortical plate (CP), and in the diencephalic SVZ; however, the molecular identities of the Abracl-expressing cell populations were not defined in that work.
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- Pancreatic cancer is a serious illness and is the seventh biggest cause of cancer deaths globally, with nearly half a million people dying from it each year.
- The most common type of this cancer, called pancreatic ductal adenocarcinoma (PDAC), is very aggressive and has low survival rates due to genetic changes in certain key genes.
- Researchers are studying how autophagy (the process cells use to clean out damaged parts) affects cancer stem cells in PDAC and are exploring new treatments that could target this process to help fight the disease.