Publications by authors named "Dimitri Desvillechabrol"
Bioinformatics is a field known for the numerous standards and formats that have been developed over the years. This plethora of formats, sometimes complementary, and often redundant, poses many challenges to bioinformatics data analysts. They constantly need to find the best tool to convert their data into the suitable format, which is often a complex, technical and time consuming task.
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- The study focuses on a pathogenic fungus and investigates its survival mechanisms, specifically the role of a transcription factor called PIG1 in the production of dihydroxynaphtalene (DHN)-melanin.
- By using CRISPR-Cas9 to create deletion mutants, researchers found that the absence of PIG1 hindered melanin production, resulting in a thinner and disorganized cell wall that decreased the fungus's ability to survive environmental stressors.
- The research highlights that PIG1 not only aids in melanin biosynthesis but may also play a crucial role in the fungus's overall virulence by helping it evade the host immune response.
Travel to tropical regions is associated with high risk of acquiring extended-spectrum beta-lactamase-producing (ESBL-E) that are typically cleared in less than 3 months following return. The conditions leading to persistent carriage that exceeds 3 months in some travellers require investigation. Whole-genome sequencing (Illumina MiSeq) was performed on the 82 ESBL-E isolates detected upon return and 1, 2, 3, 6 and 12 months later from the stools of 11 long-term (>3 months) ESBL-E carriers following travel abroad.
View Article and Find Full Text PDFBackground: In addition to mapping quality information, the Genome coverage contains valuable biological information such as the presence of repetitive regions, deleted genes, or copy number variations (CNVs). It is essential to take into consideration atypical regions, trends (e.g.
View Article and Find Full Text PDFSummary: We designed a PyQt graphical user interface-Sequanix-aimed at democratizing the use of Snakemake pipelines in the NGS space and beyond. By default, Sequanix includes Sequana NGS pipelines (Snakemake format) (http://sequana.readthedocs.
View Article and Find Full Text PDFAMMOS2 is an interactive web server for efficient computational refinement of protein-small organic molecule complexes. The AMMOS2 protocol employs atomic-level energy minimization of a large number of experimental or modeled protein-ligand complexes. The web server is based on the previously developed standalone software AMMOS (Automatic Molecular Mechanics Optimization for in silico Screening).
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