Publications by authors named "Dimitre S Simeonov"
Article Synopsis
- Proper activation of cytotoxic T cells is crucial for fighting off viruses and cancers, and involves interactions between the T cell receptor and the CD28 costimulatory receptor.
- Research identified a regulatory circuit involving the long non-coding RNA (Metastasis Associated Lung Adenocarcinoma Transcript 1) and the tumor-suppressor microRNA family miR-15/16, important for T cell activation and memory.
- Using CRISPR technology, the study demonstrated that disrupting the miR-15/16 binding site affected T cell activation and memory, highlighting the significant role of non-coding RNAs in the immune response.
