Publications by authors named "Dimitra Zambouli"
As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd with GaBr(3) or GaCl(3) resulted in the mononuclear complexes [GaBr(3)(btaH)(2)] (1) and [GaCl(3)(btd)(2)] (2), respectively, while treatment of GaCl(3) with L resulted in the anionic complex (LH)(2)[GaCl(4)] (3). All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.
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- Genistein is a natural isoflavone that enhances cell death and apoptosis from DNA-damaging agents, like camptothecins, in cancer cell lines (HeLa and OAW-42) and normal fibroblasts (L929).
- The study used the SRB method in 96-well plates for analysis, showing that genistein effectively boosts the anti-proliferative effects of camptothecins by disrupting the G2/M cell cycle checkpoint.
- In HeLa cells, genistein reduces CDK1 phosphorylation following irinotecan treatment, suggesting that it could be a strategic way to increase the effectiveness of DNA-damaging treatments.