Development of enzymatically crosslinked natural deep eutectogels: versatile gels for enhanced drug delivery.

Injectable hydrogels have been extensively studied due to their minimally invasive properties, ease of application, and void-filling properties. In this work, we tested the possibility to prepare a new type of gels, so called eutectogels, where water is replaced by a natural deep eutectic system (NADES), conferring it longer stability. Eutectogels based on betaine : glycerol 1 : 2, were prepared by enzymatic mediated crosslinking, using horseradish peroxidase (HRP) as catalyst and gelatine-phenol conjugated polymer.