Publications by authors named "Dimitar Ourdev"
Article Synopsis
- The movement of calcium ions (Ca(2+)) between the endoplasmic reticulum (ER) and mitochondria is crucial for maintaining cellular metabolism, especially in tumor cells where this process is often disrupted, contributing to chemotherapy resistance and tumor growth.
- TMX1, a redox-sensitive protein located at the mitochondria-associated membrane (MAM), is linked to the regulation of this Ca(2+) flux; low levels of TMX1 result in altered calcium dynamics that favor cancer progression.
- TMX1 functions as a tumor suppressor by enhancing mitochondrial ATP production and apoptosis, but it needs specific modifications to effectively target MAM and facilitate ER-mitochondria communication.
Background: Amyloid-β (Aβ) peptides are a family of proteins that are considered to be a principal aspect of Alzheimer's disease (AD), the most common cause of senile dementia affecting elderly individuals. These peptides result from the proteolytic processing of amyloid precursor protein (APP) by sequential cleavage mediated via β- and x03B3;-secretases. Evidence suggests that an overproduction and/or a lack of degradation may increase brain Aβ levels which, in turn, contribute to neuronal loss and development of AD.
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